Coupling to lactosaminated poly-L-lysine reduces the toxic effects of ribavirin on red blood cells [2]

Journal of Hepatology

Volumn 29, Issue 6, 1998, Pages 1032-1033

  Fiume, L ^a   Di Stefano, G ^a   Busi, C ^a   Incitti, F ^a   Rapicetta, M ^a   Farina, C ^a   Gervasi, G B ^a   Bonino, F ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; LACTOSE; POLYLYSINE; RIBAVIRIN;

BLOOD TOXICITY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG PENETRATION; DRUG RELEASE; ERYTHROCYTE; FEMALE; HEPATITIS C; INTRAMUSCULAR DRUG ADMINISTRATION; LETTER; MONKEY; NONHUMAN; PRIORITY JOURNAL;

EID: 0031771961     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80137-2     Document Type: Letter

References (5)

1. SW Schalm BE Hansen L Chemello A Bellobuono JT Brouwer O Weiland Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C. Metaanalysis of individual patient data from European centers J Hepatol 26 1997 961 966
2. O Reichard G Norkrans A Frydén JH Braconier A Sonnerborg O Weiland Randomised, double-blind, placebo-controlled trial of interferon-2b with and without ribavirin for chronic hepatitis C Lancet 351 1998 83 87
3. G Di Stefano FP Colonna A Bongini C Busi A Mattioli L Fiume Ribavirin conjugated with lactosaminated poly-L-lysine: selective delivery to the liver and increased antiviral activity in mice with viral hepatitis Biochem Pharmacol 54 1997 357 363
4. G Di Stafano A Bignamini C Busi FP Colonna L Fiume Enhanced accumulation of ribavirin and its metabolites in liver versus erythrocytes in mice administered with the liver targeted drug Ital. J Gastroenterol Hepatol 29 1997 420 426
5. L Fiume G Di Stefano C Busi A Mattioli A Bonino M Torrani Cerenzia Liver targeting of antiviral nucleoside analogues through the asialoglycoprotein receptor J Viral Hep 4 1997 363 370