Calcitonin gene-related peptide-induced relaxation of isolated human colonic smooth muscle cells through different intracellular pathways

Biochemical Pharmacology

Volumn 56, Issue 9, 1998, Pages 1097-1104

  Boyer, Jean Christophe ^a   Christen, Marie Odile ^c   Balmes, Jean Louis ^a   Bali, Jean Pierre ^a,b  

^a DEPARTMENT OF NEUROLOGY   (France)

^b CNRS   (France)

^c Laboratoires Solvay Pharma   (France)

Author keywords

Calcitonin gene related peptide; Circular muscle layer; Colon; Relaxation; Smooth muscle; Sodium nitroprusside

Indexed keywords

ADENOSINE 3',5' PHOSPHOROTHIOATE; CALCITONIN GENE RELATED PEPTIDE; CARBACHOL; CYCLIC AMP; CYCLIC GMP; GUANYLATE CYCLASE; N (2 AMINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N5 (1 IMINOETHYL)ORNITHINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; INTESTINE MUSCLE; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION;

AGED; AGED, 80 AND OVER; CALCITONIN GENE-RELATED PEPTIDE; CARBACHOL; COLON; CYCLIC GMP; FEMALE; HUMANS; ISOQUINOLINES; MALE; MIDDLE AGED; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; NITROPRUSSIDE; ORNITHINE; SULFONAMIDES;

EID: 0031771511     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00130-0     Document Type: Article

References (26)

1. Crema A, Del Tacca M, Frigo GM, and Lecchini S, Presence of a non-adrenergic inhibitory system in the human colon. Gut 9: 633-637, 1968.
2. Amara SG, Jonas V, and Rosenfeld MG, Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptides products. Nature 298: 240-244, 1982.
3. Sternini C, Enteric and visceral afferent CGRP neurons. Targets of innervation and differential expression patterns. Ann NY Acad Sci 657: 170-186, 1992.
4. Poyner DR, Calcitonin gene-related peptide: Multiples actions, multiples receptors. Pharmacol Ther 56: 23-51, 1990.
5. Feher E, Burnstock G, Vardnell IM, and Pollack JM, Calcitonin gene-related peptide immunoreactive nerve fibres in the small intestine of the guinea-pig: Electron microscopic immunochemistry. Cell Tissue Res 245: 353-358, 1986.
6. Raybould HE, Inhibitory effects of calcitonin gene-related peptide on gastrointestinal motility. Ann NY Acad Sci 657: 248-256, 1992.
7. Jensen RT, Zhou ZC, Gu ZF, Kitsukawa V, Honda T, and Maton PN, Interaction of calcitonin gene-related peptides with pancreatic acinar cells and dispersed gastric smooth muscle cells. Ann NY Acad Sci 657: 268-269, 1992.
8. Larsson LT, Hirschprungs disease, Immunohistochemical findings. Histol Histopath 9: 615-629, 1994.
9. Grider JR, Murthy KS, Jin JG, and Makhlouf GM, Stimulation of nitric oxide from muscle cells by VIP prejunctional enhancement of VIP release. Am J Physiol 264: G774-G778, 1992.
10. Jin JG, Misra S, Grider JR, and Makhlouf GM, Functional difference between SP and NKA: Relaxation of gastric muscle by SP is mediated by VIP and NO. Am J Physiol 264: G678-G685, 1993.
11. Murthy KS, Zhang KM, Jin JG, Grider JR, and Makhlouf GM, VIP-mediated G protein-coupled Ca influx activates a constitutive NOS in dispersed gastric muscle cells. Am J Physiol 265: G660-G671, 1993.
12. Shew RL, Papka RE, Mac Neill DL, and Yee JA, NADPH-diaphorase-positive nerves and the role of nitric oxide in CGRP relaxation of uterine contraction. Peptides 14: 637-641, 1993.
13. Kline LW and Pang PKT, Nitric oxide modulates the calcitonin gene-related peptide-induced relaxation in guinea-pig gallbladder strips in vitro. Regul Pept 50: 207-212, 1994.
14. Bitar KN and Makhlouf GM, Receptors on smooth muscle cells: Characterization by contraction and specific antagonists. Am J Physiol 242: G400-G407, 1982.
15. Boyer JC, Guitton C, Pignodel C, Cuq P, Moussu P, Pouderoux P, Christen MO, Balmès JL, and Bali JP, Differential responsiveness to contractile agents of isolated smooth muscle cells from human colons as a function of age and inflammation. Dig Dis Sci 42: 2190-2196, 1997.
16. Jin JG, Murthy KS, Grider JR, and Makhlouf GM, Activation of distinct c-AMP and c-GMP dependent pathways by relaxant agents in isolated gastric muscle cells. Am J Physiol 264: G470-G477, 1993.
17. Collins SM and Gardner JD, Cholecystokinin-induced contraction of dispersed smooth muscle cells. Am. J Physiol 243: G497-G504, 1982.
18. Cuq P, Magous R, and Bali JP, Pharmacological coupling and functional role of the muscarinic receptor subtypes in isolated cells from the circular smooth muscle of the rabbit caecum. J Pharmacol Exp Ther 271: 149-155, 1994.
19. Kerr PM, Hillier K, Wallis RM, and Garland CJ, Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon. Br J Pharmacol 115: 1518-1524, 1995.
20. Gomez A, Martos F, Bellido I, Marquez E, Garcia AJ, Pavia J, and Sanchez de la Cuesta F, Muscarinic receptor subtypes in human and rat colon smooth muscle. Biochem Pharmacol 43: 2413-2419, 1992.
21. Teng B, Murthy KS, Kuemmerle JF, Grider JR, and Makhlouf GM, Expression of constitutive endothelial nitric oxide synthase (eNOS) in rabbit and human gastrointestinal smooth muscle cells. Gastroenterology 110: A-1125, 1996.
22. Rekik M, Delvaux M, Tack I, Frexinos J, and Bueno L, VIP-induced relaxation of guinea-pig intestinal smooth muscle cells: Sequential involvement of cyclic AMP and nitric oxide. Br J Pharmacol 118: 477-484, 1996.
23. Francis SH, Noblett BD, Todd BW, Wells JN, and Corbin JD, Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol Pharmacol 34: 506-517, 1988.
24. 2+ activated, phospholipid-dependent and other protein kinases. J Biol Chem 260: 2922-2925, 1985.
25. Louis JC, Revel MO, and Zwiller J, Activation of soluble guanylate cyclase through phosphorylation by protein kinase C in intact PC 12 cells. Biochim Biophys Acta 1177: 299-306, 1993.
26. Sun YD and Benishin CG, Effects of calcitonin gene-related peptide on cyclic AMP production and relaxation of longitudinal muscle of guinea-pig ileum. Peptides 16: 293-297, 1995.