Pharmacokinetics and antidiuretic effect of intravenous administration of desmopressin in orally overhydrated male volunteers

Pharmacology and Toxicology

Volumn 83, Issue 6, 1998, Pages 259-262

  Callréus, Torbjörn ^a   Höglund, Peter ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPRESSIN; DRINKING WATER; VASOPRESSIN DERIVATIVE;

ADULT; ARTICLE; BLOOD SAMPLING; DIURESIS; DRUG ELIMINATION; HALF LIFE TIME; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYDRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICTURITION; NORMAL HUMAN; PRIORITY JOURNAL; STEADY STATE;

EID: 0031770622     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1998.tb01479.x     Document Type: Article

References (19)

1. d'Agay-Abensour, L., A. Fjellestad-Paulsen, P. Höglund, Y. Ngô, O. Paulsen & J. C. Rambaud: Absolute bioavailability of an aqueous solution of 1-deamino-8-D-arginine vasopressin from different regions of the gastrointestinal tract in man. Eur. J. Clin. Pharmacol. 1993, 44, 473-476.
2. Cobb, W. E., S. Pare & S. Reichlin: Neurogenic diabetes insipidus: management with dDAVP (1-desamino-8-D-arginine vasopressin). Ann. Intern. Med. 1978, 88, 183-188.
3. David, J. L.: Desmopressin and hemostasis. Regul. Pept. 1993, 45, 311-317.
4. Fjellestad-Paulsen, A. & P. Czernichow: Central diabetes insipidus in children. V. Oral treatment with a vasopressin hormone analogue (DDAVP). Acta paediatr. scand. 1986, 75, 605-610.
5. Fjellestad-Paulsen, A., N. Tubiana-Rufi, A. Harris & P. Czernichow: Central diabetes insipidus in children. Antidiuretic effect and pharmacokinetics of intranasal and peroral 1-deamino-8-D-arginine vasopressin. Acta endocrinol. 1987, 115, 307-312.
6. Fjellestad-Paulsen, A., P. Höglund, S. Lundin & O. Paulsen: Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers. Clin. Endocrinol. 1993, 38, 177-182.
7. Fjellestad-Paulsen, A., L. d'Agay-Abensour, P Höglund & J.-C. Rambaud: Bioavailability of 1-deamino-8-D-arginine vasopressin with an enzyme inhibitor (aprotinin) from the small intestine in healthy volunteers. Eur. J. Clin. Pharmacol. 1996, 50, 491-495.
8. Gebruers, E. M. & W. J. Hall: Role of the gastrointestinal tract in the regulation of hydration in man. Dig. Dis. 1992, 10, 112-120.
9. Geelen, G., J. E. Greenleaf L. C. Keil: Drinking-induced plasma vasopressin and norepinephrine changes in dehydrated humans. J. Clin. Endocrin. Metab. 1996, 81(6), 2131-2135.
10. Hammer, M. & H. Vilhardt: Peroral treatment of diabetes insipidus with a polypeptide hormone analog, desmopressin. J. Pharmacol. Exp. Therap. 1985, 234(3), 754-760.
11. Köhler, M. & A. Harris: Pharmacokinetics and haematological effects of desmopressin. Eur. J. Clin. Pharmacol. 1988, 35, 281-285.
12. Lam, K. S. L., M. S. Wat, K. L. Choi, T. P. Ip, R. W. C. Pang & C. R. Kumana: Pharmacokinetics, pharmacodynamics, long-term efficacy and safety of oral 1-deamino-8-D-arginine vasopressin in adult patients with central diabetes insipidus. Brit. J. Clin. Pharmacol. 1996, 42, 379-385.
13. Lundin, S., P. Melin & H. Vilhardt: Plasma concentrations of 1-deamino-8-D-arginine vasopressin after intragastric administration in the rat. Acta endocrinol. 1985, 108, 179-183.
14. Robinson, A. G.: DDAVP in the treatment of central diabetes insipidus. New Engl. J. Med. 1976, 294(10), 507-511.
15. Sukhai, R. N.: Enuresis nocturna: long term use and safety aspects of minrin (desmopressin) spray. Regul. Pept. 1993, 45, 309-310.
16. Vilhardt, H. & P. Bie: Antidiuretic effect of perorally administered DDAVP in hydrated humans. Acta endocrinol. 1984, 105, 474-476.
17. Vilhardt, H. & S. Lundin: Biological effect and plasma concentrations of DDAVP after intranasal and peroral administration to humans. Gen. Pharmacol. 1986, 17(4), 481-483.
18. Vilhardt, H., S. Lundin & J. Falch: Plasma kinetics of DDAVP in man. Acta pharmacol. et toxicol. 1986, 58, 379-381.
19. Williams, T. D. M., D. B. Dunger, C. C. Lyon, R. J. Lewis, F. Taylor & S. L. Lightman: Antidiuretic effect and pharmacokinetics of oral 1-desamino-8-D-arginine vasopressin. 1. Studies in adults and children. J. Clin. Endocrinol. Metab. 1986, 63(1), 129-132.