State-related changes in upper airway caliber and surrounding soft- tissue structures in normal subjects

American Journal of Respiratory and Critical Care Medicine

Volumn 158, Issue 4, 1998, Pages 1259-1270

  Trudo, Frank J ^a   Gefter, Warren B ^a   Welch, Kevin C ^a   Gupta, Krishanu B ^a   Maislin, Greg ^a   Schwab, Richard J ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AIRWAY CONSTRICTION; AIRWAY DYNAMICS; AIRWAY OBSTRUCTION; ARTICLE; CLINICAL PROTOCOL; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHARYNX; POLYSOMNOGRAPHY; PRIORITY JOURNAL; REGRESSION ANALYSIS; SLEEP; SLEEP APNEA SYNDROME; SOFT PALATE; TONGUE; UPPER RESPIRATORY TRACT; WAKEFULNESS;

EID: 0031770141     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.158.4.9712063     Document Type: Article

References (42)

1. Wheatley, J. R., W. S. Mezzanotte, D. J. Tangel, and D. P. White. 1993. Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am. Rev. Respir. Dis. 148:597-605.
2. Kuna, S. T., J. S. Smickley, and C. R. Vanoye. 1997. Respiratory-related pharyngeal constrictor muscle activity in normal human adults. Am. Rev. Respir. Dis. 155:1991-1999.
3. Wiegand, L., C. W. Zwillich, D. Wiegand, and D. P. White. 1991. Changes in upper airway muscle activation and ventilation during phasic REM sleep in normal men. J. Appl. Physiol. 71:448-497.
4. Carlson, D. M., E. Önal, O. W. Carley, M. Lopata, and R. C. Basner. 1995. Palatal muscle electromyogram activity in obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 152:1022-1027.
5. Hudgel, D. W. 1992. Mechanisms of obstructive sleep apnea. Chest 101: 541-549.
6. Wiegand, L., C. W. Zwillich, and D. P. White. 1989. Collapsibility of the human upper airway during normal sleep. J. Appl. Physiol. 66:1800-1808.
7. Wiegand, D. A., B. Latz, C. W. Zwillich, and L. Wiegand. 1990. Upper airway resistance and geniohyoid muscle activity in normal men during wakefulness and sleep. J. Appl. Physiol. 69:1252-1261.
8. Wheatley, J. R., D. J. Tangel, W. S. Mezzanotte, and D. P. White. 1993. Influence of sleep on response to negative pressure of tensor palatini muscle and retropalatal airway. J. Appl. Physiol. 75:2117-2124.
9. Schwab, R. J., K. B. Gupta, W. B. Gefter, L. J. Metzger, E. A. Hoffman, and A. I. Pack. 1995. Upper airway and soft tissue anatomy in normal subjects and patients with sleep disordered breathing. Am. J. Respir. Crit. Care Med. 152:1673-1689.
10. Schwab, R. J. 1996. Properties of tissues surrounding the upper airway. Sleep 19:S170-S174.
11. Schwab, R. J., A. I. Pack, K. B. Gupta, L. J. Metzger, E. Oh, J. E. Getsy, E. A. Hoffman, and W. B. Gefter. 1996. Upper airway and soft tissue structural changes induced by CPAP in normal subjects. Am. J. Respir. Crit. Care Med. 154:1106-1116.
12. Schwab, R. J., W. B. Gefter, E. A. Hoffman, K. B. Gupta, and A. I. Pack. 1993. Dynamic upper airway imaging during awake respiration in normal subjects and patients with sleep disordered breathing. Am. Rev. Respir. Dis. 148:1385-1400.
13. Schwab, R. J., W. B. Gefter, A. I. Pack, and E. A. Hoffman. 1993. Dynamic imaging of the upper airway during respiration in normal subjects. J. Appl. Physiol. 74:1504-1514.
14. Hudgel, D. W. 1986. Variable site of airway narrowing among obstructive sleep apnea patients. J. Appl. Physiol. 61:1403-1409.
15. Suto, Y., T. Matsuo, T. Kato, I. Hori, Y. Inoue, S. Ogawa, T. Suzuki, M. Yamada, and Y. Ohta. 1993. Evaluation of the pharyngeal airway in patients with sleep apnea: value of ultrafast MR imaging. A.J.R. 160: 311-314.
16. Stein, M. G., G. Gamsu, G. de Geer, J. A. Golden, R. E. Crumley, and W. R. Webb. 1987. Cine CT in obstructive sleep apnea. A.J.R. 148: 1069-1074.
17. Crumley, R. L., M. Stein, J. Golden, G. Gamsu, and S. Dermon. 1987. Determination of obstructive site in obstructive sleep apnea. Laryngoscope 97:301-308.
18. Horner, R. L., S. A. Shea, J. McIvor, and A. Guz. 1989. Pharyngeal size and shape during wakefulness and sleep in patients with obstructive sleep apnoea. Q. J. Med. 72:719-735.
19. Rechtschaffen, A., and A. Kales. 1968. A manual of standardized terminology: techniques and scoring system for sleep stages of human subjects. Brain Information Service/Brain Research Institute, UCLA, Los Angeles. NIH Publication No. 204.
20. Staley, B., L. J. Metzger, K. B. Gupta, and R. J. Schwab. 1994. A novel technique utilizing a tactile stimulus to determine sleep and wakefulness (abstract). Sleep Res. 23:468.
21. Gupta, K. B., R. J. Schwab, J. D. Hoford, A. I. Pack, H. A. Hoffman, and W. B. Gefter. 1992. Effect of neck position on upper airway dimensions (abstract). Am. Rev. Respir. Dis. 145:A412.
22. Gupta, K. B., G. A. Holland, J. D. Hoford, J. Listerud, and W. B. Gefter. 1992. Postprocessing of MRA images for evaluation of vessel abnormalities (abstract). Society of Magnetic Resonance in Medicine 11th Annual Scientific Meeting, Berlin, Germany, August 8-14.
23. Suto, Y., E. Matsuda, Y. Inoue, T. Suzuki, and Y. Ohta. 1996. Sleep apnea syndrome: comparison of MR imaging of the oropharynx with physiologic indexes. Radiology 201:393-398.
24. Persson, H. E., and E. Svanborg. 1996. Sleep deprivation worsens obstructive sleep apnea. Chest 109:645-650.
25. Dolly, F. R., and A. J. Block. 1982. Effect of flurazepam on sleep disordered breathing and nocturnal oxygen desaturation in asymptomatic subjects. Am. J. Med. 73:239-243.
26. Ogilvie, R. D., and R. T. Wilkinson. 1988. Behavioral versus EEG-based monitoring of all-night sleep/wake patterns. Sleep 11:139-155.
27. Ogilvie, R. D., R. T. Wilkinson, and S. Allison. 1989. The detection of sleep onset: behavioral, physiological, and subjective convergence. Sleep 12:458-474.
28. Ives, J. R., S. Warach, F. Schmitt, R. R. Edelman, and D. L. Schomer. 1993. Monitoring the patient's EEG during echo planar MRI. Electroencephalogr, Clin. Neurophysiol. 87:417-420.
29. Ives, J. R., R. Thomas, P. M. Jakob, K. O. Lovblad, J. Matheson, T. Scammell, R. R. Edelman, S. Warach, and D. L. Schomer. 1997. Technique and methodology for recording/monitoring the subject's sleep stage during "quiet" functional magnetic resonance imaging (abstract). Sleep Res. 26:665.
30. Schwab, R. J. 1995. Control of respiration during sleep. In Pulmonary Pathophysiology. M. A. Grippi, editor. J. B. Lippincott, Philadephia. 253-266.
31. Horner, R. I., 1996. Motor control of the pharyngeal musculature and implications for the pathogenesis of obstructive sleep apnea. Sleep 19: 827-853.
32. Lowe, A. A., N. Gionhaku, K. Takeuchi, and J. A. Fleetham. 1986. Three-dimensional CT reconstructions of tongue and airway in adult subjects with obstructive sleep apnea. Am. J. Orthod. Dentofacial Orthoped. 90:364-374.
33. Ryan, C. F., A. A. Lowe, D. Li, and J. A. Fleetham. 1991. Three-dimensional upper airway computed tomography in obstructive sleep apnea. Am. Rev. Respir. Dis. 144:428-432.
34. Lowe, A. A. 1990. The tongue and airway. Otolaryngol. Clin. North Am. 23:677-696.
35. Hudgel, D. W., R. J. Martin, B. Johnson, and P. Hill. 1984. Mechanics of the respiratory system and breathing pattern during sleep in normal humans. J. Appl. Physiol. 56:133-137.
36. Kay, A., J. Trinder, and Y. Kim. 1996. Progressive changes in airway resistance during sleep. J. Appl. Physiol. 81:282-292.
37. Kay, A., J. Trinder, and Y. Kim. 1995. Individual differences in relationship between upper airway resistance and ventilation during sleep onset. J. Appl. Physiol. 79:411-419.
38. Morrison, D. L., S. H. Launois, S. Isono, T. R. Feroah, W. A. White-law, and J. E. Remmers. 1993. Pharyngeal narrowing and closing pressures in patients with obstructive sleep apnea. Am. Rev. Respir. Dis. 148: 606-611.
39. Borowiecki, B., C. P. Pollak, E. D. Weitzman, S. Rakoff, and J. Imperato. 1978. Fibro-optic study of pharyngeal airway during sleep in patients with hypersomnia obstructive sleep-apnea syndrome. Laryngoscope 88:1310-1313.
40. Isono, S., J. E. Remmers, A. Tanaka, Y. Sho, J. Sato, and T. Nishino. 1997. Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects. J. Appl. Physiol. 82:1319-1326.
41. Badr, M. S., F. Toiber, J. B. Skatrud, and J. Dempsey. 1995. Pharyngeal narrowing/occlusion during central sleep apnea. J. Appl. Physiol. 78: 1806-1815.
42. Deegan, P. C., P. Nolan, M. Carey, and W. T. McNicholas. 1996. Effects of positive airway pressure on upper airway dilator muscle activity and ventilatory timing. J. Appl. Physiol. 81:470-479.