Protective action of capsaicin and chilli on haemorrhagic shock-induced gastric mucosal injury in the rat

Journal of Gastroenterology and Hepatology (Australia)

Volumn 13, Issue 10, 1998, Pages 1007-1014

  Teng, Choo Hua ^a,c   Kang, Jin Yong ^b   Wee, Aileen ^a   Lee, Kok Onn ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b JAMES PAGET UNIVERSITY HOSPITAL   (United Kingdom)

^c Ministry of Defence Government of Singapore   (Singapore)

Author keywords

Capsaicin; Capsaicin sensitive afferent neurons; Chilli; Gastric mucosal injury; Haemorrhagic shock

Indexed keywords

CAPSAICIN;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; HEMORRHAGIC SHOCK; MALE; NONHUMAN; PEPPER; PRIORITY JOURNAL; RAT; STOMACH INJURY; STOMACH MUCOSA; STOMACH PROTECTION; VASOCONSTRICTION;

EID: 0031770109     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1998.tb00562.x     Document Type: Article

References (33)

1. Lam SK, Hui WM. Stress ulcer bleeding in the critically ill. J. Gastroenterol. Hepatol. 1987; 2 (Suppl. 1): 27-35.
2. Shuman RB, Schuster DP, Zuckerman GR. Prophylactic therapy for stress ulcer bleeding: A reappraisal. Ann. Int. Med. 1987; 106: 562-7.
3. Silen W. Experimental models of gastric ulceration and injury. Am. J. Physiol. 1988; 255: G395-402.
4. Kivilaakso E, Fromm D, Silen W. Relationship between ulceration and intraluminal pH of gastric mucosa during haemorrhagic shock. Surgery 1978; 84: 70-8.
5. Owen DAA, Parsons ME, Farrington HE, Blakemore R. Reduction by cimetidine of acute gastric haemorrhage caused by reinfusion of blood after exposure to exogenous acid during gastric ischaemia in rats. Gastroenterology 1979; 77: 979-85.
6. Menguy R, Desbaillets L, Masters YF. Mechanism of stress ulcer. Influence of hypovolemic shock on energy metabolism in the gastric mucosa. Gastroenterology 1979; 66, 46-55.
7. Itoh M, Guth PH. Role of oxygen-derived free radicals in haemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 1985; 88: 1162-7.
8. Smith SM, Holm-Rutlli L, Perry MA et al. Role of neutrophils in haemorrhagic shock-induced gastric mucosal injury in the rat. Gastroenterology 1987; 93: 466-71.
9. Iwai A, Itoh M, Yokoyama Y et al. Role of PAF in ischaemia-reperfusion injury in the rat stomach. Scand. J. Gastroenterol. 1989; 24 (Suppl. 162): 63-6.
10. Holzer P, Pabst MA, Lippe IT et al. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterology 1990; 98: 838-48.
11. Uchida M, Yano S, Watanabe K. The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesion in rats. Jpn J. Pharmacol 1991; 55: 279-82.
12. Kang JY, Teng CH, Wee A, Chen FC. Effect of capsaicin and chilli on ethanol-induced gastric mucosal injury in the rat. Gut 1995; 36: 664-9.
13. Holzer P, Lippe IT. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience 1988; 27: 981-7.
14. Szolcsanyi J, Bartho L. Impaired defense mechanism to peptic ulcer in the capsaicin-desensitised rat. Adv. Physiol. Sci. 1981; 29: 39-51.
15. Holzer P, Pabst MA, Lippe IT. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology 1990; 96: 1425-33.
16. Takeuchi K, Ueshima K, Ohuchi T, Okabe S. The role of capsaicin-sensitive sensory neurons in healing of HCl-induced gastric mucosal lesions in rats. Gastroenterology 1994; 106: 1524-32.
17. Kang JY, Teng CH, Chen FC. The effect of capsaicin and cimetidine on the healing of acetic acid-induced gastric ulceration in the rat. Gut 1996; 38: 832-6.
18. Yeoh KG, Kang JY, Yap I et al. Chilli protects against aspirin-induced gastroduodenal mucosal injury in humans. Dig. Dis. Sci. 1995; 40: 580-3.
19. Li DS, Raybould HE, Quintero E, Guth PH. Role of calcitonin gene-related peptide in gastric hyperaemic response to intragastric capsaicin. Am. J. Physiol. 1991; 261: G657-61.
20. Ranta-knuuttila T, Kiviluoto T, Hyvarinen H, Lehtola A, Kivilaakso E. Prostaglandin protection against haemorrhage-induced gastric stress ulceration in the rat. Dig. Dis. Sci. 1989; 34: 1028-34.
21. Wallace JL, Boichot E, Sidoti C, Brecx A, Paubert-Braquet M. Protective effects of somatostatin against gastric damage induced by haemorrhagic shock, stress and platelet activating factor in the rat. Regul. Pept. 1993; 47: 195-203.
22. Blandizzi C, Gherardi G, Natale G, Marveggio C, Del Tacca M. Protective action of omeprazole against gastric mucosal injury induced by haemorrhagic shock in rats. Dig. Dis. Sci. 1994; 39: 2109-17.
23. Ishikawa T, Tarnawski A, Sarfeh IJ, Stachura J. Epidermal growth factor protects gastric mucosa against ischaemia-reperfusion injury. J. Clin. Gastroenterol. 1993; 17 (Suppl. 1): S104-10.
24. Kelly SM, Crampton J, Hunter JO. Decreased salivary EGF in rheumatoid disease; a possible mechanism for increased susceptibility to gastric ulceration. Br. Med. J. 1990; 301: 422-3.
25. Konturek SJ, Bielanski W, Konturek JW, Oleksy J, Yamazaki J. Release and action of epidermal growth factor on gastric secretion in humans. Scand. J. Gastroenterol. 1989; 24: 485-92.
26. Kang JY, Yeoh KG, Chia HP et al. Chilli-protective factor against peptic ulcer? Dig. Dis. Sci. 1995; 40: 576-9.
27. Yonei Y, Holzer P, Guth PH. Laparotomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons. Gastroenterology 1990; 99: 3-9.
28. Buck SH, Burks TF. The neuropharmacology of capsaicin. Review of some recent observations. Pharmacol. Rev. 1986; 38: 179-226.
29. Mersereau WA, Hinchey EJ. Effect of gastric acidity on gastric ulceration induced by haemorrhage in the rat, utilising a gastric chamber technique. Gastroenterology 1973; 64: 1130-5.
30. 3 protects gastric mucosa against acute ulceration in the rat. Gastroenterology 1981; 81: 921-7.
31. Lacy ER, Ito S. Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 1982; 83: 619-25.
32. SAS User's Guide. Statistics. Version 5 edition. North Carolina: SAS Institute Inc., 1985.
33. Steel RGD, Torrie JH. Principles and Procedures of Statistics - A Biometrical Approach, 2nd edn.York: McGraw-Hill, 1980.