Radiobiological prediction of normal tissue toxicities and tumour response in the radiotherapy of advanced non-small-cell lung cancer

British Journal of Cancer

Volumn 78, Issue 12, 1998, Pages 1629-1633

  Singer, J M ^a   Price, P ^b   Dale, R G ^c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Non small cell lung cancer; Radiobiological modelling; Radiotherapy

Indexed keywords

ADVANCED CANCER; ARTICLE; CANCER RADIOTHERAPY; CLINICAL TRIAL; HUMAN; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; META ANALYSIS; PRIORITY JOURNAL; RADIATION DOSE; SPINAL CORD DISEASE;

EID: 0031770090     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.734     Document Type: Article

References (13)

1. Barendsen GW (1982) Dose fractionation, dose-rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys 8: 1991-1997
2. Dale RG, Jones B and Price P (1997) Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer 33: 1707-1708
3. Fowler JF (1989) The linear-quadratic formula and progress in fractionation. Br J Radiol 62: 679-694
4. Hendry JH, Bentzen SM, Dale RG, Fowler JF, Wheldon TE, Jones B, Munro AJ, Slevin NJ and Robertson AG (1996) A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy. Clin Oncol 8: 297-307
5. Joiner MC and van der Kogel AJ (1997) The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In Basic Clinical Radiobiology, 2nd edn, Steel GG (ed.), pp. 106-122. London: Edward Arnold
6. Macbeth FR, Wheldon TE, Girling DJ, Stephens RJ, Machin D, Bleehan NM, Lamont A, Radstone DJ and Reed NS (1996) Radiation myelopathy: estimates of risk in 1048 patients in three randomised trials of palliative radiotherapy for non-small cell lung cancer. Clin Oncol 8: 176-181
7. Maher EJ, Timothy A and Squire CJ (1993) Audit: the use of radiotherapy for NSCLC in the UK. Clin Oncol 5: 72-79
8. MRC LCWP (Medical Research Council Lung Cancer Working Part) (1991) Inoperable non-small-cell lung cancer (NSCLC): a Medical Research Council randomised trial of palliative radiotherapy with two fractions or ten fractions. Br J Cancer 63: 265-270
9. MRC LCWP (Medical Research Council Lung Cancer Working Party) (1992) A Medical Research Council (MRC) randomised trial of palliative radiotherapy with two fractions or a single fraction in patients with inoperable non-small-cell lung cancer (NSCLC) and poor performance status. Br J Cancer 65: 934-941
10. MRC LCWP (Medical Research Council Lung Cancer Working Party) (1996) Randomised trial of palliative two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status. Clin Oncol 8: 167-175
11. Perez CA, Stanley K, Ruben P, Karma S, Bride L, Perez-Tame R, Brown GS, Coneannon J, Rotman M and Seydel HG (1980) A prospective randomised study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. Cancer 45: 2744-2753
12. Rees GJG, Devrell CE, Barley VL and Newman HFV (1997) Palliative radiotherapy for lung cancer: two versus five fractions. Clin Oncol 9: 90-95
13. Stewart FA (1997) Re-treatment tolerance of normal tissues. In Basic Clinical Radiobiology, 2nd edn. Steel GG (ed.), pp. 203-211. London: Edward Arnold