HDL-cholesterol reductions associated with adult growth hormone replacement

Clinical Endocrinology

Volumn 49, Issue 5, 1998, Pages 673-677

  Leese, G P ^a   Wallymahmed, M ^b   VanHeyningen, C ^b   Tames, F ^b   Wieringa, G ^c   MacFarlane, I A ^b  

^a NINEWELLS HOSPITAL   (United Kingdom)

^b WALTON HOSPITAL   (United Kingdom)

^c CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HUMAN GROWTH HORMONE; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROGENESIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE SUBSTITUTION; HUMAN; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOLYSIS; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSSPHENOIDAL SURGERY;

ADULT; CHOLESTEROL; CHOLESTEROL, HDL; DOUBLE-BLIND METHOD; FEMALE; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIPOPROTEIN(A); MALE; MIDDLE AGED; TIME FACTORS; TRIGLYCERIDES;

EID: 0031769978     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00597.x     Document Type: Article

References (27)

1. Asayama, K., Amemiyu, S., Kusano, S. & Kato, K. (1984) Growth hormone induced changes in postheparin plasma lipoprotein lipase and hepatictriglyceride lipase activities. Metabolism, 33, 129-131.
2. Austin, A., Warty, V., Janosky, J. & Arslanian, S. (1993) The relationship of physical fitness to lipid and lipoprotein (a) levels in adolescents with IDDM. Diabetes Care, 16, 421-425.
3. Beshayh, S.A., Henderson, A., Niththyananthan, R., Skinner, E., Anyaoku, V., Richmond, W., Sharp, P. & Johnston, D.G. (1995) The effects of short and long term growth hormone replacement therapy in hypopituitary adults on lipid metabolism and carbohydrate tolerance. Journal of Clinical Endocrinology and Metabolism, 80, 356-363.
4. Binnerts, A., Roel Stewart, G., Paul Wilson, J.H., Hoogerbrugge, N., Pols, H.A.P., Birkenhager, J.C. & Lamberts, S.W.J. (1992) The effects of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clinical Endocrinology, 37, 79-87.
5. Blackett, P.R., Weech, P.K., McConathy, W.J. & Fesmire, J.D. (1982) Growth hormone in the regulation of hyperlipidaemia. Metabolism, 31, 117-120.
6. Cuneo, R.C., Salomon, F., Watts, G.F., Hesp, R. & Sonsken, P.H. (1993) Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism, 42, 1519-1523.
7. deBoer, H., Blok, G.J., Voerman, H.J., Philips, M. & Schouten, J.A. (1994) Serum lipids in growth hormone deficient men. Metabolism, 43, 199-203.
8. Duell, P.B., Hagemenas, F. & Connor, W.E. (1994) The relationship between serum lipoprotein (a) and insulinemia in healthy non-diabetic adult men., Diabetes Care, 17, 1135-1140.
9. Eden, S., Wiklund, O., Oscarsson, J., Rosen, T. & Bengtsson, B.-A. (1993) Growth hormone treatment of growth hormone deficient adults results in a marked increase in Lp(a) and HDL-cholesterol concentrations. Arteriosclerosis und Thrombosis, 13, 296-301.
10. Friedwald, W.T., Levy, R.L. & Fredrickson, D.S. (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clinical Chemistry, 18, 499-502.
11. Garry, P., Collins, P. & Devlin, J.G. (1996) An open 36-month study of lipid changes with growth hormone in adults: lipid changes following replacement of growth hormone in adult acquired growth hormone deficiency. European Journal of Endocrinology, 134, 61-66.
12. Hassan, H.M.S., Kohno, H., Kuromaru, R., Honda, S. & Ueda, K. (1995) Lipoprotein (a) changes during growth hormone treatment. Clinical Endocrinology, 43, 655 (letter).
13. Hubinger, L., Mackinnon, L.T. & Lepre, F. (1995) Lipoprotein (a) levels in middle aged male runners and sedentary controls. Medicine Science Sports and Exercise, 27, 490-496.
14. Hussey, R. (1993) Liverpool public health annual report (Table A17) p71. Liverpool Health Authority, Liverpool.
15. Mackness, M.I., Bhatnagar, D., Wieringa, G., Mbewu, A., Haynes, B. & Durrington, P.N. (1996) A comparative study of six commercial lipoprotein (a) assays in seventeen laboratories within the British Isles. Annals of Clinical Biochemistry, 33, 63-70.
16. O'Halloran, D.J.O., Weiringa, G., Tsatsoulis, A. & Shalet, S. (1996) Increased serum lipoprotein (a) concentrations after growth hormone (GH) treatment in patients with isolated growth hormone deficiency. Annals of Clinical Biochemistry, 33, 330-334.
17. Oscarsson, J., Olofsson, S.O., Bondjers, G. & Eden, S. (1989) Differential effects of continuous versus intermittent administration of growth hormone to hypophysectomized female rats on serum lipoproteins and their apoproteins. Endocrinology, 125, 1638-1649.
18. Oscarsson, J., Carlsson, L.M.S., Bick, T., Lidell, A., Olofsson, S.O. & Eden, S. (1991a) Evidence for a role of the secretory pattern of growth hormone in the regulation of serum concentrations of cholesterol and apolipoprotein E. Journal of Endocrinology, 128, 433-438.
19. Oscarsson, J., Olofsson, S.O., Vikman, K. & Eden, S. (1991b) Growth hormone regulation of serum lipoproteins in the rat: Different growth hormone regulatory principles for apolipoprotein (apo) B and the sexually dimorphic apo E concentrations. Metabolism, 40, 1191-1198.
20. Oscarsson, J., Ottosson, M., Wiklund, O., Marin, P., Vikman-Adolfsson, Bjorntorp, P. & Eden, S. (1994) Low dose continuously infused growth hormone results in increased lipoprotein (a) and decreased low density lipoprotein cholesterol concentrations in middle aged men. Clinical Endocrinology, 41, 109-116.
21. Rosen, T. & Bengtsson, B.A. (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet, 336, 285-288.
22. Russell-Jones, D.L., Watts, G.F., Weissberger, A., Naoumova, R., Myers, J., Thompson, G.R. & Sonksen, P.H. (1994) The effect of growth hormone replacement on serum lipids, lipoproteins, apolipoproteins and cholesterol precursors in adult growth hormone deficient patients. Clinical Endocrinology, 41, 345-350.
23. Salomon, F., Cuneo, R.C., Hesp, R. & Sonksen, P.H. (1989) The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. New England Journal of Medicine, 321, 1797-1803.
24. Thomas, T.R., Ziogas, G. & Harris, W.S. (1997) Influence of fitness status on very low density lipoprotein subfractions and lipoprotein (a) in men and women. Metabolism, 46, 1178-1183.
25. Wallymahmed, M.E., Humphris, G., Baker, G., Dewey, M. & MacFarlane, I.A. (1996) The development, reliability and validity of a disease specific quality of life model for adults with growth hormone deficiency. Clinical Endocrinology, 44, 403-411.
26. Wallymahmed, M.E., Foy, P., Shaw, D., Hutcheon, R., Edwards, R.H.T. & MacFarlane, I.A. (1997) Quality of life, body composition and muscle strength in adult growth hormone deficiency: the influence of growth hormone replacement therapy for up to 3 years. Clinical Endocrinology, 47, 439-446.
27. Weaver, J.U., Monson, J.P., Noonan, K., John, W.G., Edwards, J.A., Evans, K.A. & Cunningham, J. (1995) The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity and cardiovascular risk factors in hypopituitary adults. Journal of Clinical Endocrinology and Metabolism, 80, 153-159.