The germ cell - The mother of all stem cells

International Journal of Developmental Biology

Volumn 42, Issue 7, 1998, Pages 1043-1050

  Donovan, Peter J ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

EG cells; Embryo; Mouse; PGC; Teratoma

Indexed keywords

ANIMAL CELL; ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; EMBRYO; EMBRYONAL CARCINOMA; GERM LAYER; GERM LINE; MALE; MALE FERTILITY; NONHUMAN; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; STEM CELL; TERATOMA; TESTIS CANCER;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CULTURE TECHNIQUES; EMBRYO; FEMALE; GERM CELLS; MALE; MICE; STEM CELLS; TERATOMA; TUMOR STEM CELLS;

EID: 0031769409     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (76)

1. ASADA, Y., VARNUM, D.S , FRANKEL, W N and NADEAU, J H. (1994) A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18 Nature Genet 6: 363-368.
2. BEDELL, M A., BRANNAN, C.I., EVANS, E.P., COPELAND, N.G , JENKINS, N.A and DONOVAN, P J. (1995). DNA rearrangements located over 100 kb 5′ of the Steel (Sl)-coding region in the Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development. Genes Dev 9 455-470
3. BIRD, J M and KIMBER, S.J (1984). Oligosaccharides containing fucose linked a(1-3) and a(1-4) to N-acetylglucosamine cause decompaction of mouse morulae Dev Biol. 104 449-460
4. BLANDAU, R J., WHITE, B J and RUMMERY, R.E (1963) Observations on the movements of living primordial germ cells in the mouse Fertil Steril 14: 482-489
5. BRANNAN, C I, BEDELL, M A., RESNICK, J.L., EPPIG, J J., HANDEL, M A., WILLIAMS, D E , LYMAN, S D , DONOVAN, P.J., JENKINS, N.A. and COPELAND, N G (1992) Developmental abnormalities in Steel 17H mice result from a splicing defect in the steel factor cytoplasmic tail. Genes Dev. 6 : 1832-1842.
6. BRANNAN, C.I , LYMAN, S D., WILLIAMS, D.E., EISENMAN, J , ANDERSON, D M., COSMAN, D , BEDELL, M A , JENKINS, N.A. and COPELAND, N.G (1991). Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains Proc. Natl Acad. Sci. USA 88: 4671-4674.
7. BRINSTER, R L. (1974). The effect of cells transferred into the mouse blastocyst on subsequent development. J. Exp. Med. 140: 1049.
8. BRINSTER, R L. and HARSTAD, H. (1977). Energy metabolism in primordial germ cells of the mouse Exp. Cell Res 109 111-117.
9. BUEHR, M., MCLAREN, A , BARTLEY, A and DARLING, S (1993). Proliferation and migration of primordial germ cells in We/We mouse embryos. Dev Dynamics 198: 182-189.
10. CHABOT, B., STEPHENSON, D.A., CHAPMAN, V.M., BESMER, P. and BERNSTEIN, A (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335. 88-89.
11. CHENG, L., GEARING, D.P , WHITE, L.S., COMPTON, D.L., SCHOOLEY, K and DONOVAN, P.J. (1994). Role of leukemia inhibitory factor and its receptor in mouse primondal germ cell growth. Development 120: 3145-3153.
12. COOKE, J.E., HEASMAN, J. and WYLIE, C.C. (1996). The role of interleukin-4 in the regulation of mouse primordial germ cell numbers. Dev. Biol. 174: 14-21.
13. COPELAND, N.G , GILBERT, D.J., CHO, B.C., DONOVAN, P.J., JENKINS, N A., COSMAN, D., ANDERSON, D , LYMAN, S D and WILLIAMS, D.E. (1990) Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel allele Cell 63. 175-183.
14. DE FELICI, M and DOLCI, S. (1991). Leukemia inhibitory factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers. Dev. Biol 147: 281-284.
15. DE FELICI, M. and MCLAREN, A. (1982). Isolation of mouse primoridal germ cells. Exp. Cell Res. 142: 476-482.
16. DE FELICI, M. and MCLAREN, A (1983). In vitro culture of mouse primoridal germ cells. Exp. Cell Res 744. 417-427.
17. DOLCI, S., PESCE, M. and DE FELICI, M. (1993) Combined action of stem cell factor, leukemia inhibitory factor and cAMP on in vitro proliferation of mouse primordial germ cells. Mol. Reprod Dev. 2: 134-139.
18. DOLCI, S., WILLIAMS, D.E., ERNST, M.K., RESNICK, J.L., BRANNAN, C.I., LOCK, L.F., LYMAN, S.D., BOSWELL, H.S. and DONOVAN, P.J. (1991). Requirements for mast cell growth factor for primordial germ cell survival in culture. Nature 352. 809-811.
19. DONOVAN, P.J. (1993). Growth factor regulation of mouse primordial germ cell development. Curr. Top. Dev. Biol. 29: 189-225,.
20. DONOVAN, P J., STOTT, D , CAIRNS, L.A , HEASMAN, J. and WYLIE, C.C. (1986) Migratory and postmigratory mouse primordial germ cells behave differently in culture. Cell 44: 831-838.
21. DONOVAN, P.J., STOTT, D., GODIN, I., HEASMAN, J. and WYLIE, C.C. (1987). Studies on the migration of mouse germ cells J. Cell Sci. (Suppl.) 8: 359-367
22. DRUCKER, B J. and GOLDFARB, M. (1993) Murine FGF-4 gene expression is spatially restricted within embryonic skeletal muscle and other tissues Mech. Dev. 40. 155-163.
23. DUNCAN, M., CUMMINGS, L and CHADA, K. (1993). Germ cell deficient (gcd) mouse as a model of premature ovarian failure. Biol Reprod. 49: 221-227.
24. DUNCAN, M K., LIEMAN, J. and CHADA, K K. (1995) The germ cell deficient locus maps to mouse Chromosome 11A2-3. Mammal Genome 6. 697-699.
25. FLANAGAN, J G., CHAN, D C. and LEDER, P. (1991). Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant Cell 164 1025-1035
26. FOX, N D.I , MARTINEZ-HERNADEZ, A., KNOWLES, B.B. and SOLTER, D. (1981). Immunohistochemical localization of the early embryonic antigen (SSEA-1) in postimplantation mouse embryos and fetal and adult tissues Dev. Biol. 83: 391-398.
27. FURITSU, T., TSUJIMURA, T , TONO, T., IKEDA, H , KITAYAMA, H., KOSHIMIZU, U., SUGAHARA, H , BUTTERFIELD, J.H., ASHMAN, L.K , KANAYAMA, Y., MATSUZAWA, Y , KITAMURA, Y and KANAKURA. (1993). Identification of mutations in the coding sequence of the protooncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J. Clin. Invest. 92: 1736-1744
28. GEISSLER, E.N., RYAN, M A and HOUSMAN, D E. (1988) The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55: 185-192.
29. GODIN, I., DEED, R., COOKE, J., ZSEBO, K , DEXTER, M. and WYLIE, C.C. (1991) Effects of the steel gene product on mouse primordial germ cells in culture. Nature 352. 807-809
30. HERTWIG, P (1942). Neue mutationen und koppelungsgruppen bei der hausmaus. Z Indukt Abstammungs-Vererbungsl 80: 220-246.
31. HILSCHER, B , HILSCHER, W., BULTHOFF-OHNOLZ, B., KRAMER, U., BIRKE, A., PELZER, H. and GAUSS, G. (1974). Kinetics of gametogenesis Cell Tissue Res. 154: 443-470.
32. ILLMENSEE, K. (1978). Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice. In Genetic Mosaics and Chimeras in Mammals. (Ed. L. Russell), Plenum Press, New York, p 3
33. ILLMENSEE, K. and MINTZ, B. (1976). Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc. Natl. Acad. Sci. USA 73: 549-553.
34. KAWASE, E., YAMAMOTO, H., HASHIMOTO, K. and NAKATSUJI, N. (1994). Tumor necrosis factor-alpha (TNF-alpha) stimulates proliferation of mouse primordial germ cells in culture. Dev. Biol. 161: 91-95.
35. KOSHIMIZU, U , TAGA, T , WATANABE, M., SAITO, M., SHIRAYOSHI, Y., KISHIMOTO, T and NAKATSUJI, N. (1996). Functional requirement of gp 130-mediated signaling for growth and survival of mouse primordial germ cells in vitro and derivation of embryonic germ (EG) cells Development 122: 1235-1242.
36. KOSHIMIZU, U., WATANABE, M and NAKATSUJI, N (1995). Retinoic acid is a potent growth activator of mouse primordial germ cells in vitro. Dev. Biol. 168: 683-685.
37. LABOSKY, P.A., BARLOW, D.P. and HOGAN, B.L. (1994a). Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. Development 120: 3197-3204
38. LABOSKY, P.A , BARLOW, D.P. and HOGAN, B.L. (1994b). Embryonic germ cell lines and their derivation from mouse primordial germ cells Ciba Found. Symp. 182: 157-168.
39. LONGLEY, B.J , TYRRELL, L , LU, S Z., MA, Y.S , LANGLEY, K., DING, T G , DUFFY, T., JACOBS, P., TANG, L.H. and MODLIN, I. (1996) Somatic c-Kit activating mutation in urticaria pigmentosa and aggressive mastocytosis. establishment of clonality in a human mast cell neoplasm. Nature Genet. 12: 312-314.
40. MACGREGOR, G.R , ZAMBROWICZ, B.P. and SORIANO, P (1995). Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells. Development 121: 1487-1496.
41. MARTIN, G.R. and LOCK, L.F. (1983). Pluripotent cell lines derived from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. In Teratocarcinoma Stem Cells (Eds Silver, L.M., Martin, G.R. and Strickland, S.). Cold Spring Harbor Laboratory, NY.
42. MATSUBARA, N., TAKAHASHI, Y , NISHINA, Y , MUKOUYAMA, Y., YANAGISAWA, M., WATANABE, T., NAKANO, T., NOMURA, K., ARITA, H., NISHIMUNE, Y., OBINATA, M. and MATSUI, Y (1996). A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primoridal germ cell growth or survival in culture Dev. Biol. 180: 499-510.
43. MATSUI, Y. (1997) Regulation of growth and survival of germ cells Hum. Cell 10: 63-68.
44. MATSUI, Y , TOKSOZ, D., NISHIKAWA, S., NISHIKAWA, S., WILLIAMS, D., ZSEBO, K and HOGAN, B L. (1991). Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture Nature 353. 750-752.
45. MATSUI, Y , ZSEBO, K and HOGAN, B.L. (1992). Derivation of pluripotential embryonic stem cells from murine primoridal germ cells in culture. Cell 70: 841-847
46. MCCARREY, J R., HSU, K.C., EDDY, E.M., KLEVECZ, R.R. and BOLEN, J.L. (1987). Isolation of viable mouse primoridal germ cells by antibody-directed flow sorting. J Exp Zool. 242: 107-111.
47. MCCOSHEN, J A. and MCCALLION, D.J. (1975). A study of primordial germ cells during their migratory phase in steel mutant mice. Experientia 31: 589-590.
48. MCKINNON, R D., MATSUI, T., DUBOIS-DALCQ, M. and AARONSON, S.A. (1990). FGF modulates the PDGF driven pathway of oligodendrocyte development. Neuron 5. 603-614.
49. MCLAREN, A (1981). Germ Cells and Soma. A New Look at an Old Problem. Yale University Press, New Haven, CT
50. NISWANDER, L and MARTIN, G R (1992). FGF-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse Development 114. 755-768.
51. PAPAIOANNOU, V.E (1979) Interactions between mouse embryos and teratocarcinomas. IN-SERM Symp 10: 141.
52. PAPAIOANNOU, V.E , MCBURNEY, M.W., GARDNER, R.L. and EVANS, R.L. (1975). Fate of teratocarcinoma cells injected into early mouse embryos. Nature 258: 70-73.
53. PELLAS, T.C., RAMACHANDRAN, B., DUNCAN, M., PAN, S.S., MARONE, M. and CHADA, K. (1991). Germ-cell deficient (gcd), and insertional mutation manifested as infertility in transgenic mice. Proc. Natl. Acad. Sci. USA 88: 8787-8791.
54. PESCE, M., CANIPARI, R., FERRI, G L. SIRACUSA, G. and DE FELICI, M. (1996). Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells. Development 122: 215-221.
55. PESCE, M., DI CARLO, A. and DE FELICI, M. (1997). The c-kit receptor is involved in the adhesion of mouse primordial germ cells to somatic cells in culture. Mech. Dev 68: 37-44.
56. PESCE, M., FARRACE, M.G., PIACENTINI, M., DOLCI, S. and DE FELICI, M. (1993). Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by supressing programmed cell death (apoptosis). Development 4: 1089-1094.
57. PIAO, X., PAULSON, R., VAN DER GEER, P., PAWSON, T. and BERNSTEIN, A. (1996). Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc. Natl. Acad Sci. USA 10: 14665-14669.
58. QUI, F , RAY, P. BROWN, K., BARKER, P.E., JHANWAR, S., RUDDLE, F H. and BESMER, P (1988). Primary structure of c-kit relationship with the CSF-1/PDGF receptor kinase family - oncogenic activation of v-kit involves deletion of extracellular domain and C-terminus. EMBO J. 7: 1003-1011.
59. RAJPERT-DE MEYTS, E. and SKAKKEBAEK, N E. (1994) Expression of the c-kit protein product in carcinoma-in situ and invasive testicular germ cell tumours. Int. J. Androl. 17. 85-92.
60. RESNICK, J.L., BIXLER, L S., CHENG, L. and DONOVAN, P. J. (1992). Long-term proliferation of mouse primoridal germ cells in culture. Nature 359: 550-551.
61. RUSSELL, E. S., MCFARLAND, E.C and PETERS, H. (1985) Gametic and Pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. Dev Biol. 110: 331-337.
62. SAKURAI, T , IGUCHI, T , MORIWAKI, K. and NOGUCHI, M. (1995). The termutation first causes primordial germ cell deficiency in ter/ter mouse embryos at 8 days of gestation. Dev. Growth Differ. 37: 293-302.
63. SAKURAI, T., KATOH, H., MORIWAKI, K., NOGUCHI, T. and NOGUCHI, M. (1994) The ter primordial germ cell deficiency mutation maps near Grl-1 on mouse Chromosome 18. Mammal. Genome 5. 333-336.
64. SOLTER, D and KNOWLES, B.B (1978). Monoclonal antibody defining a stage-specific embryonic antigen (SSEA-1). Proc. Natl. Acad Sci. USA 75: 5565-5569.
65. STEVENS, L.C. (1966). Development of resistance to teratocarcinogenesis by primoridal germ cells in mice. J Natl Cancer Inst. 37: 859-867.
66. STEVENS, L.C. (1967). Origin of testivular teratomas from primordial germ cells in mice. J Natl. Cancer Inst. 38. 549-552.
67. STEWART, C.L., GADI, I. and BHATT, H.I. (1994). Stem cells from primordial germ cells can reenter the germ line. Dev. Biol. 161: 626-628.
68. STOTT, D. and WYLIE, C.C (1986). Invasive behaviour of mouse primordial germ cells in vitro. J. Cell Sci. 86: 133-144
69. TAN, J.C., NOCKA, K., RAY, P., TRAKTMAN, P. and BESMER, P. (1990). The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science 247: 209-212.
70. WHITNEY, M.A., ROYLE, G., LOW, M J , KELLY, M.A., AXTHELM, M.K., REIFSTECK, C., OLSON, S., BRAUN, R E., HEINRICH, M.C., RATHBUN, R.K , BAGBY G C and GROMPE, M. (1996). Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood 88: 49-58.
71. WYLIE, C.C., STOTT, D. and DONOVAN, P.J. (1985). Primordial germ cell migration. In Developmental Biology: A Comprehensive Synthesis, (Browder, L , ed.) Vol. 2 The cellular basis of morphogenesis. Plenum Press, NY,.
72. YARDEN, Y., KUANG, W.J., YANG-FENG, T., COUSSENS, L., MUNEMITSU, S , DULL, T.J., CHEN, E., SCHLESSINGER, J., FRANCKE, U and ULLRICH, A. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand EMBO J 6: 3341-3351.
73. YEOM, Y I., FUHRMANN, G., OVITT, C.E., BREHM, A., OHBO, K., GROSS, M., HUBNER, K. and SCHÖLER, H.R. (1996). Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122: 881-894.
74. YOSHIDA, K., TAGA, T , SAITO, M., SUEMATSU, S., KUMANOGOH, A., TANAKA, T., FUJIWARA, H , HIRATA, M., YAMAGAMI, T., NAKAHATA, T., HIRABAYASHI, T., YONEDA, Y., TANAKA, K., WANG, W.Z., MORI, C., SHIOTA, K , YOSHA, N. and KISHIMOTO, T. (1996) Targeted disruption of gp 130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl Acad. Sci. USA 93: 407-411.
75. ZHAO, C Q., DENG, K , LABOSKY, P.A., LIAW, L. and HOGAN, B.L. (1996). The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev 10: 1657-1669.
76. ZSEBO, K.M., WILLIAMS, D.A., GEISSLER, E.N., BROUDY, V.C., MARTIN, F.H., ATKINS, H.L. HSU, R.Y , BIRKETT, N C., OKINO, K.H., MURDOCK, D.C., JACOBSEN, F.W., LANGLEY, K.E , SMITH, K.A., TAKEISHI, T , CATTANACH, B.M. GALLI, S.J. and SUGGS, S.V. (1990). Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63: 213-224.