L-alanine fermentation by an alanine racemase-deficient mutant of the DL-alanine hyperproducing bacterium Arthrobacter oxydans HAP-1

Journal of Fermentation and Bioengineering

Volumn 86, Issue 4, 1998, Pages 385-390

  Hashimoto, Shin Ichi ^a   Katsumata, Ryoichi ^a,b  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Alanine racemase; L alanine dehydrogenase; L alanine fermentation

Indexed keywords

AMINO ACIDS; BACTERIA; ENZYMES; GLUCOSE;

BACTERIAL STRAINS; MUTANT STRAINS;

FERMENTATION;

ALANINE;

AMINO ACID METABOLISM; ARTHROBACTER; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; FERMENTATION; ISOMERISM; NONHUMAN;

ARTHROBACTER; ARTHROBACTER OXYDANS; BACTERIA (MICROORGANISMS);

EID: 0031768514     PISSN: 0922338X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0922-338X(99)89009-6     Document Type: Article

References (18)

1. Nakayama, K.: Amino acids, p. 748-794. In Reed, G. (ed.), Prescott & Dunn's industrial microbiology, 4th ed. Ari Publishing Company, Westport, CT (1982).
2. Kitai, A.: Alanine, p. 325-337. In Yamada, K., Kinoshita, S., Tsunoda, T., and Aida, K. (ed.), The microbial production of amino acids. John Wiley & Sons, New York (1970).
3. Perry, J. J.: Production of L-alanine by biotin-deficient Micrococcus sodonensis. J. Bacteriol., 94, 1249-1250 (1967).
4. Hirose, Y. and Yamada, K.: Studies on the amino acids fermentation of pentose materials. Agric. Biol. Chem., 25, 410-416 (1961).
5. Calton, G. J.: The enzymatic preparation of L-alanine, p. 60-74. In Rozzell, J. D. and Wagner, E. (ed.), Biocatalytic production of amino acids and derivatives. John Wiley & Sons, New York (1992).
6. Chibata, I., Kakimoto, T., and Kato, J.: Enzymatic production of L-alanine by Pseudomonas dacunhae. Appl. Microbiol., 13, 638-645 (1965).
7. Wild, J., Henning, J., Lobocka, M., Walczak, W., and Klopotowski, T.: Identification of the dadX gene coding for the predominant isozyme of alanine racemase in Escherichia coli K12. Mol. Gen. Genet., 198, 315-322 (1985).
8. Wasserman, S. A., Walsh, C.T., and Botstein, D.: Two alanine racemase from Salmonella typhimurium that differ in structure and function. J. Bacteriol., 153, 1439-1450 (1983).
9. Tan-Wilson, A. L.: Alanine biosynthesis and the general transaminases, p. 19-34. In Herrmann, K. M. and Somerville, R. L. (ed.), Amino acid biosynthesis and genetic regulation. Addison-Wesley, London (1983).
10. Hashimoto, S. and Hashimoto, S.: Overproduction of alanine by Arthrobacter strains with glucose-nonrepressible L-alanine dehydrogenase. Biotech. Lett., 15, 1117-1122 (1993).
11. Bradford, M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
12. Adams, E., Mukherjee, K. L., and Dunathan, H. C.: Alanine racemase of Pseudomonas. Arch. Biochem. Biophys., 165, 126-132 (1974).
13. Ozaki, A., Kawasaki, H., Yagasaki, M., and Hashimoto, Y.: Enzymatic production of D-alanine from DL-alanineamide by novel D-alanineamide specific amide hydrolase. Biosci. Biotech. Biochem., 56, 1980-1984 (1992).
14. Adams, E.: Amino acid racemases and epimerases, p. 479-507. In Boyer, P. D. (ed.), The enzymes, vol. 6. Academic Press, New York (1970).
15. Lambert, M. P and Neuhaus, F. C.: Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W. J. Bacteriol., 110, 978-987 (1972).
16. Protivinsky, R.: Cycloserine. Antibiot. Chemother., 17, 87-94 (1971).
17. Strominger, J. L., Ito, E., and Threnn, R. H.: Competitive inhibition of enzymatic reactions by oxamycin. J. Am. Chem. Soc., 82, 998-999 (1960).
18. Bochner, B. R. and Savageau, M. A.: Generalized indicator plate for genetic, metabolic, and taxonomic studies with microorganisms. Appl. Environ. Microb., 33, 434-444 (1977).