Improved autonomic neurocardial balance in short-term abstinent alcoholics treated with acamprosate

Alcohol and Alcoholism

Volumn 33, Issue 6, 1998, Pages 602-605

  Agelink, M W ^b   Lemmer, W ^b   Malessa, R ^a   Zeit, T ^b   Majewski, T ^b   Klieser, E ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACAMPROSATE; ALCOHOL;

ADULT; ALCOHOLISM; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART RATE VARIABILITY; HUMAN; MALE; PARASYMPATHETIC NERVE; PHARMACODYNAMICS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYMPATHETIC NERVE; VAGUS NERVE;

EID: 0031768240     PISSN: 07350414     EISSN: None     Source Type: Journal    
DOI: 10.1093/alcalc/33.6.602     Document Type: Article

References (21)

1. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. American Psychiatric Association, Washington, DC.
2. Ben-David, J. and Zipes, D. P. (1988) Autonomic neural modulation of cardiac rhythm, Part I: Basic concepts. Modern Concepts of Cardiovascular Disease 57, 41-46.
3. Berger, R. D., Akselrod, S., Gordon, D. and Cohen, R. J. (1986) An efficient algorithm for spectral analysis of heart rate variability. IEEE Transaction on Biomedical Engineering 33, 900-904.
4. Boismare, F., Daoust, M., Moore, N. D., Saligaut, C., Lhuintre, J. P., Chretien, P. and Durlach, J. A. (1984) A homotaurine derivate reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved? Pharmacology, Biochemistry and Behaviour 21, 787-789.
5. Chabenat, C., Chretien, P., Daoust, M., Moore, N. D., Andre, D., Lhuintre, J. P., Saligaut, C., Boucly, P. and Boismare, F. (1988) Physiochemical, pharmacological and pharmacokinetic study of a new GABAergic compound, calcium acetyl-homotaurinate. Methods and Findings in Experimental and Clinical Pharmacology 10, 311-317.
6. Daoust, M., Legrand, E., Gewiss, M., Heidbreder, C., De Witte, P., Tran, G. and Durbin, P. (1992) Acamprosate modulates synaptosomal GABA transmission in chronically alcoholised rats. Pharmacology, Biochemistry and Behaviour 41, 669-674.
7. DiMicco, J. A. (1987) Evidence for control of cardiac vagal tone by benzodiazepine receptors. Neuropharmacology 26, 553-559.
8. Durbin, P., Hulot, T. and Chabac, S. (1996) Pharmacodynamics and pharmacokinetics of acamprosate: an overview. In Acamprosate in Relapse Prevention of Alcoholism. Proceedings of the First Campral Symposium ESBRA, Stuttgart 1995, Soyka, M. ed., pp. 47-64. Springer, Berlin.
9. Gerra, G., Caccavari, R., Delsignore, R., Vourna, S., Maestra, D., Ugolotti, G. and Passeri, M. (1992) Pituitary responses to Ca-acetyl-homotaurinate in normal subjects and alcoholics. Neuroendocrinology Letters 14, 119-126.
10. Hirsch, J. A., Bishop, B. and York, J. L. (1993) Recovery of respiratory sinus arrhythmia in detoxified alcoholic subjects. Journal of Applied Physiology 74, 1816-1823.
11. Johnson, R. H. and Robinson, B. J. (1988) Mortality in alcoholics with autonomic neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 51, 476-480.
12. Littleton, J. (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90, 1179-1188.
13. Paille, F. M., Guelfi, J. D., Perkins, A. C., Royer, R. J., Steru, L. and Parot, P. (1995) Double-blind randomised multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol and Alcoholism 30, 239-247.
14. Rechlin, T., Orbes, I., Weis, M. and Kaschka, W. P. (1996) Autonomic cardiac abnormalities in alcohol dependent patients admitted to a psychiatric department. Journal of Clinical Autonomic Research 6, 119-122.
15. Sass, H., Soyka, M., Mann, K. and Zieglgänsberger, W. (1996) Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Archives of General Psychiatry 53, 673-680.
16. Villalta, J., Estruch, R., Antunez, E., Valls, J. and Urbano-Marquez, A. (1989) Vagal neuropathy in chronic alcoholics: relation to ethanol consumption. Alcohol and Alcoholism 24, 421-428.
17. Vogel, L. R., Muskin, P. R., Collins, E. D. and Sloan, R. P. (1996) Lorazepam reduces cardiac vagal modulation in normal subjects. Journal of Clinical Psychopharmacology 16, 449-453.
18. Weise, F., Müller, D., Krell, D., Kielstein, V. and Koch, R. D. (1986) Heart rate variability in chronic alcoholics: a follow-up study. Drug and Alcohol Dependence 17, 365-368.
19. Wilde, M. I. and Wagstaff, A. J. (1997) Acamprosate. A review of its pharmacology and clinical potential in the management of alcohol dependence after detoxification. Drugs 53, 1038-1053.
20. Ziegler, D., Laux, G., Dannehel, K., Spüler, M., Mühlen, H., Mayer, P. and Gries, F. A. (1992) Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis and standard tests of heart rate variation and blood pressure response. Diabetic Medicine 9, 166-175.
21. Zieglgänsberger, W., Hauser, C., Wetzel, C., Putzke, J., Siggins, G. R. and Spanagel, R. (1996) Actions of acamprosate on neurons of the central nervous system. In Acamprosate in Relapse Prevention of Alcoholism. Proceedings of the First Campral Symposium ESBRA Stuttgart 1995, Soyka, M. ed., pp. 65-70. Springer, Berlin.