Pharmacokinetics of progesterone in postmenopausal women. 2. Pharmacokinetics following percutaneous administration

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 3, 1998, Pages 397-402

  Mircioiu, C ^a   Perju, A ^a   Griu, E ^a   Calin, G ^a   Neagu, A ^a   Enachescu, D ^b   Miron, D S ^a  

^a CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Percutaneous administration; Pharmacokinetics; Progesterone

Indexed keywords

PROGESTERONE;

AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; COMPARTMENT MODEL; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; EMULSION; FEMALE; GEL; HUMAN; POSTMENOPAUSE; RADIOIMMUNOASSAY; TOPICAL DRUG ADMINISTRATION; VENOUS BLOOD;

ADMINISTRATION, CUTANEOUS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; EMULSIONS; FEMALE; GELS; HUMANS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; POSTMENOPAUSE; PROGESTERONE; STATISTICS;

EID: 0031768141     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03192300     Document Type: Article

References (11)

1. Mauvais-Jarvis P., Vickers C.F.H., Wepierre J. (Eds) (1980) : Percutaneous absorption of steroids. London: Academic Press.
2. Kincl F.A., Ciaccio L.A., Benagiano G. (1978) : Increasing oral bioavailability of progesterone by formulation. J. Steroid Biochem., 9, 83-84.
3. Nillius S.J., Johansson E.D.B. (1971) : Plasma levels of progesterone after vaginal, rectal or intramuscular administration of progesterone. Am. J. Obstet. Gynecol., 110, 470-477.
4. Maddocks S., Hahn P., Moller F., Reid R.L. (1986): A double-blind placebo-controlled trial of progesterone vaginal suppositories in the treatment of premenstrual syndrome. Am. J. Obstet. Gynecol., 154, 573-576.
5. Mircioiu C, Perju A., Griu E., Calin G., Neagu A., Enachescu D. (1998) : Pharmacokinetics of progesterone in postmenopausal women. 1. Pharmacokinetics following intravaginal administration. Eur. J. Drug Metab. Pharmacokinet., 23, 391-396.
6. Heinzel G., Woloszczak R., Thomann P. (1993) : Pharmacokinetic and pharmacodynamic data analysis system. Stuttgart: Gustav Fischer.
7. Mircioiu C., Perju A., Enachescu D., Griu E., Neagu A. (1993) : Biodisposition and pharmacokinetics of percutaneous and intravaginal progesterone. Correlation with in vitro measurements. Third International Conference on Prediction penetration, La Grande Motte, France, 14-16 April 1993.
8. Morville R., Dray F., Regnier J., Barrat J. (1982) : Biodisponibilité de la Progesterone naturelle administré par voie orale. Mesuré de la conc. du steroid dans le plasma, l'endometre et la tissue mammaire. J. Gynecol. Obstet. Biol. Reprod., 11, 55-63.
9. Thijssen J.H., Zander J. (1966) : Progesteron 4C and its metabolites in the blood after intravenous injections into woman. Acta Endocrinol., 51, 563-567.
10. Siddiqui O., Roberts M., Polack A.E. (1989) : Percutaneous absorption of steroids: relative contributions of epidermal penetration and dermal clearance, J. Pharmacokinet. Biopharmacol., 17, 405-424.
11. Archer D.F., Fahy O.E., Viniegra-Sibal A. (1995) : Initial and steady-state pharmacokinetics of a vaginally administered formulation of progesterone. Am. J. Obstet. Gynecol., 173, 471-478.