Pregnancy-induced changes in rabbit medial collateral ligament vasoregulation

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  McDougall, Jason J ^a   Giles, Ryan W ^a   Bray, Robert C ^a   Hart, David A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Adrenergic system; Blood flow; Knee joints; Laser Doppler perfusion imaging; Neuropeptides

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR; CALCITONIN GENE RELATED PEPTIDE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; KNEE LIGAMENT; LASER DOPPLER FLOWMETRY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RABBIT; TISSUE PERFUSION; VASOCONSTRICTION;

EID: 0031768128     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.4.r1380     Document Type: Article

References (40)

1. Abramson, D., S. M. Roberts, and P. D. Wilson. Relaxation of the pelvic joints in pregnancy. Surg. Gynecol. Obstet. 58: 595-613, 1934.
2. Annibale, D. J., C. R. Rosenfeld, and K. E. Kamm. Alterations in vascular smooth muscle contractility during ovine pregnancy. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H1282-H1288, 1989.
3. Anouar, A., A. Schirar, and G. Germain. Relaxant effect of the calcitonin gene-related peptide (CGRP) on the nonpregnant and pregnant rat uterus. Comparison with vascular tissue. Naunyn Schmiedebergs Arch. Pharmacol. 357: 446-453, 1998.
4. Bani, G., T. Bani Sacchi, M. Bigazzi, and S. Bianchi. Effects of relaxin on the microvasculature of mouse mammary gland. Histol. Histopathol. 3: 337-343, 1988.
5. Bigazzi, M., A. Del Messe, F. Petrucci, R. Casali, and G. P. Novelli. The local administration of relaxin induces changes in the microcirculation of the rat mesocaecum. Acta Endocrinol. 112: 296-299, 1986.
6. Block, R. A., L. A. Hess, E. V. Timpano, and C. Serlo. Physiologic changes in the foot during pregnancy. J. Am. Podiatr. Med. Assoc. 75: 297-299, 1985.
7. 2-adrenoceptors in human and rat myometrium and differential expression during pregnancy. Br. J. Pharmacol. 122: 1732-1738, 1997.
8. Bray, R. C., M. R. Doschak, T. S. Gross, and R. F. Zernicke. Physiological and mechanical adaptations of rabbit medial collateral ligament after anterior cruciate ligament transection. J. Orthop. Res. 15: 830-836, 1997.
9. Bray, R. C., A. W. F. Fisher, and C. B. Frank. Fine vascular anatomy of rabbit knee ligaments. J. Anat. 172: 69-79, 1990.
10. Bray, R., K. Forrester, J. J. McDougall, A. Damji, and W. R. Ferrell. Evaluation of laser Doppler imaging to measure blood flow in knee ligaments of adult rabbits. Med. Biol. Eng. Comput. 34: 227-231, 1996.
11. Calguneri, M., H. A. Bird, and V. Wright. Changes in joint laxity occurring during pregnancy. Ann. Rheum. Dis. 41: 126-128, 1982.
12. Chowdhury, P., J. R. Matyas, and C. B. Frank. The "epiligament" of the rabbit medial collateral ligament: a quantitative morphological study. Connect. Tissue Res. 27: 33-50, 1991.
13. D'Angelo, G., and G. Osol. Regional variation in resistance artery diameter response to α-adrenergic stimulation during pregnancy. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H78-H85, 1993.
14. Dumas, G. A., and J. G. Reid. Laxity of knee cruciate ligaments during pregnancy. J. Orthop. Sports Phys. Ther. 26: 2-6, 1997.
15. Ferrell, W. R., J. J. McDougall, and R. C. Bray. Spatial heterogeneity in the effects of calcitonin gene-related peptide (CGRP) on the microvasculature of ligaments in the rabbit knee joint. Br. J. Pharmacol. 121: 1397-1405, 1997.
16. Frank, C. B., D. A. Hart, and N. G. Shrive. Molecular biology and biomechanics of normal and healing ligaments. Osteoarth. Cart. In press.
17. Gin, T. Pharmacokinetic optimisation of general anaesthesia in pregnancy. Clin. Pharmacokinet. 25: 59-70, 1993.
18. Hama, H., T. Yamamuro, and T. Takeda. Experimental studies on connective tissue of the capsular ligament: influence of ageing and sex hormones. Acta Orthop. Scand. 47: 473-479, 1976.
19. Hart, D. A., L. Roux, C. B. Frank, and N. Shrive. Sex hormone influences on rabbit ligaments in vivo and in vitro (Abstract). Trans. Orthop. Res. Soc. 21: 792, 1996.
20. Hart, D. A., P. Sciore, R. Boykiw, and C. Reno. Pregnancy induces complex changes in the pattern of gene expression in knee ligaments of the adolescent rabbit. Matrix Biol. 17: 21-34, 1998.
21. Humphreys, P. W., and N. Joels. The response of the hind-limb vascular bed of the rabbit to sympathetic stimulation and its modification by pregnancy. J. Physiol. (Lond.) 330: 475-488, 1982.
22. Karimian, S. M., J. J. McDougall, and W. R. Ferrell. Neuropeptidergic and autonomic control of the vasculature of the rat knee joint revealed by laser Doppler perfusion imaging. Exp. Physiol. 80: 341-348, 1995.
23. Lang, U., R. Baker, and K. E. Clark. Estrogen-induced increases in coronary blood flow are antagonized by inhibitors of nitric oxide synthesis. Eur. J. Obstet. Gynecol. Reprod. Biol. 74: 229-235, 1997.
24. Liu, S. H., R. Al-Shaikh, V. Panossian, R.-S. Yang, S. D. Nelson, N. Soleiman, G. A. M. Finerman, and J. M. Lane. Primary immunolocalization of estrogen and progesterone target cells in the human anterior cruciate ligament. J. Orthop. Res. 14: 526-533, 1996.
25. MacLennan, A. H., R. Nicholson, R. C. Green, and M. Bath. Serum relaxin and pelvis pain of pregnancy. Lancet 2: 243-245, 1986.
26. McDougall, J. J., and R. C. Bray. Animal Models in Orthopaedic Research. Boca Raton, FL: CRC. In press.
27. McDougall, J. J., R. C. Bray, and K. A. Sharkey. A morphological and immunohistochemical examination of nerves in normal and injured collateral ligaments of rat, rabbit and human knee joints. Anat. Rec. 248: 29-39, 1997.
28. McDougall, J. J., W. R. Ferrell, and R. C. Bray. Spatial variation in sympathetic influences on the vasculature of the synovium and medial collateral ligament of the rabbit knee joint. J. Physiol. (Lond.) 503: 435-443, 1997.
29. McKibbin, B., and A, Maroudas. Adult Articular Cartilage. Tunbridge Wells, UK: Pitman Medical, 1979, p. 461-486.
30. McLaughlin, M. K., M. S. Quinn, and J. G. Farnham. Vascular reactivity in the hind limb of the pregnant ewe. Am. J. Obstet. Gynecol. 152: 593-598, 1985.
31. Mokrzycki, M. L., K. Mittal, S. W. Smilen, A. N. Blechman, R. F. Forges, and R. I. Demopolous. Estrogen and progesterone receptors in the uterosacral ligament. Obstet. Gynecol. 90: 402-404, 1997.
32. Ostgaard, H. C., G. B. J. Anderson, A. B. Schultz, and J. A. A. Miller. Influence of some biomechanical factors on low-back pain in pregnancy. Spine 18: 61-65, 1993.
33. Roberts, J. M., P. A. Insel, R. D. Goldfien, and A. Goldfien. α-Adrenoceptors but not β-adrenoceptors increase in rabbit uterus with oestrogen. Nature 270: 624-625, 1977.
34. Rosenfeld, C. R., F. H. Morris, F. C. Battaglia, E. L. Makowski, and G. Meschia. Effect of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes. Am. J. Obstet. Gynecol. 124: 618-629, 1976.
35. Schauberger, C. W., B. L. Rooney, L. Goldsmith, D. Shenton, P. D. Silva, and A. Scharper. Peripheral joint laxity increases in pregnancy but does not correlate with serum relaxin levels. Am. J. Obstet. Gynecol. 174: 667-671, 1996.
36. Sciore, P., S. Smith, C. B. Frank, and D. A. Hart. Detection of receptors for estrogen and progesterone in human ligaments and rabbit ligaments and tendons by RT-PCR (Abstract). Trans. Orthop. Res. Soc. 22: 51, 1997.
37. Shikata, J., H. Sanada, T. Tamamuro, and T. Takeda. Experimental studies of the elastic fiber of the capsular ligament: influence of ageing and sex hormones on the hip joint capsule of rats. Connect. Tissue Res. 7: 21-27, 1979.
38. Sladek, S. M., R. R. Magness, and K. P. Conrad. Nitric oxide and pregnancy. Am. J. Physiol. 272 (Regulatory Integrative Comp. Physiol. 41): R441-R463, 1997.
39. Stevenson, J. C., D. W. R. MacDonald, R. C. Warren, M. W. Booker, and M. I. Whitehead. Increased concentration of circulating calcitonin gene related peptide during normal human pregnancy. Br. Med. J. 293: 1329-1330, 1986.
40. Wårdell, K., A. Jakobsson, and G. E. Nilsson. Laser Doppler perfusion imaging by dynamic light scattering. IEEE Trans. Biomed. Eng. 40: 309-316, 1993.