ARTICLE;
COMPARTMENT MODEL;
DRUG BLOOD LEVEL;
DRUG ELIMINATION;
DRUG METABOLISM;
DRUG TRANSFORMATION;
INTRAVENOUS DRUG ADMINISTRATION;
ORAL DRUG ADMINISTRATION;
PHARMACOKINETICS;
PRIORITY JOURNAL;
SUSTAINED RELEASE PREPARATION;
Effects of first-pass metabolism on metabolite mean residence time determination after oral administration of parent drug
Chan KKH and Gibaldi M (1990) Effects of first-pass metabolism on metabolite mean residence time determination after oral administration of parent drug. Pharm Res 7:59-63.
Morphine pharmacokinetics and metabolism in humans: Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations
Hasselström J and Säwe J (1993) Morphine pharmacokinetics and metabolism in humans: enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Clin Pharmacokinet 24:344-354.
Metabolite formation pharmacokinetics: Rate and extent of metabolite formation determined by deconvolution
Karol MD and Goodrich S (1988) Metabolite formation pharmacokinetics: rate and extent of metabolite formation determined by deconvolution. Pharm Res 5:347-351.
Pharmacokinetics of morphine-6-glucuronide and its formation from morphine following i.v.-administration
in press
Lötsch J, Weiss M, Kobal G and Geisslinger G (1998) Pharmacokinetics of morphine-6-glucuronide and its formation from morphine following i.v.-administration. Clin Pharmacol Ther, in press.
Pharmacokinetic modelling of a parent drug and its metabolite atracurium and laudanosine
Nigrovic V and Banoub M (1992) Pharmacokinetic modelling of a parent drug and its metabolite atracurium and laudanosine. Clin Pharmacokinet 22:396-408.
A general model of metabolite kinetics following intravenous and oral administration of the parent drug
Weiss M (1988) A general model of metabolite kinetics following intravenous and oral administration of the parent drug. Biopharm & Drug Dispos 9:159-176.
Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction
Weiss M (1990) Use of metabolite AUC data in bioavailability studies to discriminate between absorption and first-pass extraction. Clin Pharmacokinet 18:419-422.