Intraepidermal free nerve fiber endings and their importance for cutaneous pain;Intraepidermale freie nervenfaserendigungen und deren bedeutung fur den hautschmerz

Schmerz

Volumn 12, Issue 5, 1998, Pages 330-335

  Muller T ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Epidermis; Methylene blue; Nerve; Nociception; Skin

Indexed keywords

METHYLENE BLUE;

ARTICLE; EPIDERMIS; HISTOCHEMISTRY; MICROSCOPY; NERVE CONDUCTION; NERVE FIBER; NOCICEPTION; PAIN;

EID: 0031767278     PISSN: 0932433X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004820050161     Document Type: Article

References (42)

1. Alvarez FJ, Cervantes C, Blasco I, Villalba R, Martinez-Murillo R, Polak JM, Rodrigo J (1988) Presence of calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity in intraepidermal free nerve endings of cat skin. Brain Res 442:391
2. Arthur RP, Shelley WB (1959) The innervation of human epidermis. J Invest Dermatol 32:397
3. Böck P (1988) Romeis-Mikroskopische Technik. Urban & Schwarzenberg, München Wien Baltimore
4. Boeke J (1925) Die intrazelluläre Lage der Nervenendigungenim Epithelgewebe und ihre Beziehungen zum Zellkern. Z Mikrosk Anat Forsch 2:391
5. Boeke J (1926) Die Beziehungen der Nervenfasern zu den Bindegewebselementen und Tastzellen. Das periterminale Netzwerk der motorischen und sensiblen Nervenendigungen, seine morphologische und physiologische Bedeutung, Entwicklung und Regeneration. Z Mikrosk Anat Forsch 4:448
6. Botezat E (1908) Die Nerven der Epidermis. Anat Anz 33:45
7. Botezat E (1912) Die Apparate des Gefühlsinnes der nackten und behaarten Säugetierhaut, mit Berücksichtigung des Menschen. Anat Anz 42:273
8. Brettschneider H (1959) Elektronenmikroskopische Untersuchungen an marklosen vegetativen Nervenfasern. Verh Anat Ges 56:166
9. Cauna N (1980) Fine morphological characteristics and microtopography of the free nerve endigns of the human digital skin. Anat Rec 198:643
10. Frey M von (1895) Beiträge zur Sinnesphysiologie der Haut. Sitzungsber Saechs Akad Wiss, Math-Naturwiss KI 47:166
11. Hara M, Toyoda M, Yaar M, Bhawan J, Avila EM, Penner IR, Gilchrest BA (1996) Innervation of melanocytes in human skin. J Exp Med 184:1385
12. Hilliges M, Astbäck J, Wang L, Johansson O (1995) Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J Invest Dermatol 104:134
13. Holland NR, Stocks A, Hauer P, Cornblath DR, Griffin JW, McArthur JC (1997) Intraepidermal nerve fiber density in patients with painful sensory neuropathy. Neurology 48:708
14. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD (1993) Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature 36:159
15. Hsieh ST, Choi S, Lin WM, Chang YC, McArthur JC, Griffin JW (1996) Epidermal denervation and its effects on keratinocytes and Langerhans cell. J Neurocytol 25:513
16. Huneke W (1952) Impletoltherapie und andere neuraltherapeutische Verfahren. Hippokrates, Stuttgart
17. Ishida-Yamamoto A, Sénba E, Tohyama M (1989) Distribution and fine structure of calcitonin gene-related peptide-like immunoreactive nerve fibers in the rat skin. Brain Res 491:93
18. Jabonero V, Perez Casas A (1962) Über die feinere Innervation der Haut. I. Die Innervation der Epidermis, der Cutis und der Hautblutgefäße. Acta Neuroveg 22:353
19. Kadanoff D (1928) Über die intraepithelialen Nerven und ihre Endigungen beim Menschen und bei den Säugetieren. Z Zellforsch Mikrosk Anat 7:553
20. Kanazawa H, Yoshie S (1996) The taste bud and its innervation in the rat as studied by immunohistochemistry for PGP 9.5. Arch Histol Cytol 59:357
21. Kennedy WR, Wendelschafer-Crabb G (1993) The innervation of the human epidermis. J Neurol Sci 115:184
22. Konttinen YT, Häyrinen-Immonen RH, Nordström D, Malmström MJ, Hukkanen M, Sorsa T, Polak J (1994) Innervation of recurrent aphthous ulcers. Oral Microbiol Immunol 9:60-64
23. Kruger L, Sampogna SL, Rodin BE, Clague J, Brecha N, Yeh Y (1985) Thin-fiber cutaneous innervation and its intraepidermal contribution studied by labeling methods and neurotoxin treatments in rats. Somatosens Mot Res 2:335
24. Kruger L, Silverman JD, Mantyh PW, Sternini C, Brecha NC (1989) Peripheral patterns of calcitonin-gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J Comp Neurol 280:291
25. McCarthy BG, Hsieh ST, Stocks A, Hauer BA, Macko C, Cornblath DR, Griffin JW, McArthur JC (1995) Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 45:1848
26. Miller MR, Ralston HJ, Kasahara M (1958) The pattern of cutaneous innervation of the human hand. Am J Anat 102:183
27. Müller T (1996) The innervation of taste buds in the soft palate of the rat as revealed by methylene blue staining. Arch Histol Cytol 59:47
28. Müller T (1996) The different morphological types of dendritic cells and their innervation within stratified squamous epithelia of the rat as revealed by methylene blue staining. Biomed Res 7:225
29. Müller T (1996) Morphological differences among nerve fiber endings in the rat oral mucosa as revealed by methylene blue staining. Histol Histopathol 11:659
30. Navarro X, Verdú E, Wendelschafer-Crabb G, Kennedy WR (1995) Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study. J Neurosci Res 41:111
31. Novotny GEK, Gommert-Novotny E (1988) Intraepidermal nerves in human digital skin. Cell Tissue Res 254:111
32. Reilly DM, Ferdinando D, Johnston C, Shaw C, Buchanan KD, Green MR (1997) The epidermal nerve fibre network: characterization of nerve fibres in human skin by confocal microscopy and assessment of racial variations. Br J Dermatol:163
33. Silverman JD, Kruger L (1989) Calcitonin-gene-related-peptide-immunoreactive innervation of the rat head with emphasis on specialized sensory structures. J Comp Neurol 280:303
34. Stankovic N, Johansson O, Hildebrand C (1996) Occurrence of epidermal nerve endings in glabrous and hairy skin of the rat foot after sciatic nerve regeneration. Cell Tissue Res 284:161
35. Stöhr P (1928) Das peripherische Nerven-system. In:Möllendorff W von (Hrsg) Handbuch der Mikroskopischen Anatomie des Menschen, Bd IV/1. Springer, Berlin, S 202
36. Szymonowicz W (1895) Beiträge zur Kenntnis der Nervenendigungen in Hautgebilden. Arch Mikrosk Anat Entwicklungsgesch 45:624
37. Tretjakoff D (1902) Zur Frage der Nerven der Haut. Z Wiss Zool 71:625
38. Verdü E, Navarro X (1997) Comparison of immunohistochemical and functional reinnervation of skin and muscle after peripheral nerve injury. Exp Neurol 146:187
39. Wang L, Hilliges M, Jernberg T, Wiegleb-Edström D, Johansson O (1990) Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin. Cell Tissue Res 261:25
40. Woollard HH (1936) Intra-epidermal nerve endings. J Anat 71:54
41. Woollard HH, Weddell G, Harpman JA (1940) Observations on the neurohistological basis of cutaneous pain. J Anat 74:413
42. Yeh Y, Byers MR (1983) Fine structure and axonal transport labeling of intraepithelial sensory nerve endings in anterior hard palate of the rat. Somatosens Mot Res 1:1