Inhibition of cell proliferation by 17β-estradiol and heregulin β1 in estrogen receptor negative human breast carcinoma cell lines

Breast Cancer Research and Treatment

Volumn 51, Issue 1, 1998, Pages 71-81

  Yoo, Joo Yeon ^a   Lessor, Tracy ^a,b   Hamburger, Anne W ^a,b,c  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^c Department of Pathology ^*  (United States)

Author keywords

17 estradiol; ER negative; ErbB 2 and ErbB 3; Growth inhibition; Heregulin 1 (HRG 1); Human breast carcinoma cells

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; NEU DIFFERENTIATION FACTOR; ONCOPROTEIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DNA TRANSFECTION; ESTROGEN BINDING; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; ONCOGENE C ERB; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CARRIER PROTEINS; CELL DIVISION; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ERBB-2; GLYCOPROTEINS; GROWTH INHIBITORS; HUMANS; NEUREGULIN-1; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-3; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0031767109     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006035603635     Document Type: Article

References (36)

1. Evans RM: The steroid and thyroid hormone receptor super-family. Science 240: 889-895, 1988
2. Gronemeyer H: Transcription activity by estrogen and progesterone receptors. Annu Rev Genet 25: 89-123, 1991
3. Matsuda S, Kadowaki Y, Ichino M, Akiyama T, Toyoshima K, Yamamoto T: 17β-estradiol mimics ligand activity of the c-ErbB-2 protooncogene product. Proc Natl Acad Sci USA 90: 10803-10807, 1993
4. Nakhla AM, Khan MS, Romas NP, Rosner W: Estradiol causes the rapid accumulation of cAMP in human prostate. Proc Natl Acad Sci USA 91: 5402-5405, 1994
5. Aronica SM, Kraus WL, Katzenellenbogen BS: Estrogen action via the cAMP signaling pathway stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA 91: 8517-8521, 1994
6. Aronica SM, Katzenellenbogen BS: Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I. Mol Endocrinol 7: 743-751, 1993
7. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H, Metzger D, Chambon P: Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270: 1491-1494, 1995
8. Ignar-Trowbridge DM, Teng CT, Ross KA, Parker MG, Korach KS, McLachlan JA: Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Mol Endocrinol 7: 992-998, 1993
9. Akiyama T, Sudo C, Ogawa H, Toyosima K, Yamamoto T: The product of human c-erbB-2 gene: a 185 kilodalton glycoprotein with tyrosine kinase activity. Science 232: 1644-1646, 1986
10. Lofts FJ, Gullick WJ: Breast Cancer Cellular and Molecular Biology. Kluwer Academic Publishers, Boston, 1992
11. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182, 1987
12. McCann AH, Dervan PA, O'Regan M, Codd MB, Gullick WJ, Tobin BM, Carney DN: Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer. Cancer Res 51: 3296-3303, 1991
13. Kallioniemi OP, Holli K, Visakorpi T, Koivula T, Helin HH, Isola JJ: Association of c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer. Int J Cancer 49: 650-655, 1991
14. ErbB-2. Science 249: 1552-1555, 1990
15. ErbB-2. Science 256: 1205-1210, 1992
16. Peles E, Bacus SS, Koski RA, Lu HS, Wen D, Ogden SG, Ben Levy R, Yarden Y: Isolation of the Neu/Her-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell 69: 205-216, 1992
17. Sliwkowski MX, Schaefer G, Akita RW, Lofgren JA, Fitzpatrick VD, Nuijens A, Fendly BM, Cerione RA, Vandlen RL, Carraway KL III: Coexpression of ErbB-2 and ErbB-3 proteins reconstitutes a high affinity receptor for heregulin. J Biol Chem 269: 14661-14665, 1994
18. Bacus SS, Zelnick CR, Plowman G, Yarden Y: Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Am J Clin Pathol 102 (Suppl 1): S13-S24, 1994
19. Adnane J, Gaudray P, Simon M-P, Simony-Lafontaine J, Jeanteur P, Theillet C: Proto-oncogene amplification and human breast tumor phenotype. Oncogene 4: 1389-1395, 1989
20. Wright C, Angus B, Nicholson S, Sainsbury JRC, Cairns J, Gullick WJ, Kelly P, Harris AL, Horne CHW: Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer. Cancer Res 49: 2087-2090, 1989
21. Stal O, Sullivan S, Sun XF, Wingren S, Nordenskjold B: Simultaneous analysis of c-erbB-2 expression and DNA content in breast cancer using flow cytometry. Cytometry 16: 160-168, 1994
22. Dati C, Antoniotti S, Taverna D, Perroteau I, De Bortoli M: Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells. Oncogene 5: 1001-1006, 1990
23. Russell KS, Hung M-C: Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor. Cancer Res 52: 6624-6629, 1992
24. Antoniotti S, Maggiora P, Dati C, De Bortoli M: Tamoxifen up-regulates c-erbB-2 expression in estrogen-responsive breast cancer cells in vitro. Eur J Cancer 28: 318-321, 1992
25. Engel LW, Young NA: Human breast carcinoma cells in continuous culture: a review. Cancer Res 38: 4327-4339, 1978
26. Bacus SS, Huberman E, Chin D, Kiguchi K, Simpson S, Lippman M, Lupu RA: Ligand for the erbB-2 oncogene product (gp30) induces differentiation of human cancer cells. Cell Growth Differ 3: 401-411, 1992
27. Bacus SS, Gudkov AV, Zelnick CR, Chin D, Stern R, Stancovski I, Peles E, Ben-Baruch N, Farbstein H, Lupu R, Wen D, Sela M, Yarden Y: Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumor. Cancer Res 53: 5251-5261, 1993
28. Hamburger AW, Pinnamaneni G: Interferon induced increase in c-myc expression in a human breast carcinoma cell line. Anticancer Res 11: 1891-1894, 1991
29. Daly JM, Jannot CB, Beerli RR, Graus-Porta D, Maurer FG, Haynes NE: Neu differentiation factor induces ErbB-2 down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells. Cancer Res 57: 3804-3811, 1997
30. Sommers CL, Byers SW, Thompson EW, Torri JA, Gelmann EP: Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat 31: 325-335, 1994
31. Kang Y, Cortina R, Perry RR: Role of c-myc in tamoxifen-induced apoptosis in estrogen-independent breast cancer cells. J Natl Cancer Inst 88: 279-284, 1996
32. Pietras RJ, Arboleda J, Reese DM, Wongvipat N, Pegram MD, Ranos L, Gorman CM, Parker MG, Sliwkowski MX, Slamon DJ: Her-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells. Oncogene 10: 2435-2446, 1995
33. Tang C, Cardillo M, Yang D, Cho C, Waibel C, Perez C, Lupu R: Heregulin β2 isoform induces estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Proc Amer Assoc Cancer Res 36: 169, 1995
34. Morrison RS, Gross JL, Herblin WF, Reilly TM, LaSala PA, Alterman RL, Moskal JR, Kornblith PL, Dexter DL: Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res 50: 2524-2529, 1990
35. Chen X, Levkowitz G, Tzahar E, Karunagaran D, Lavi S, Ben-Baruch N, Leitner O, Ratzkin BJ, Bacus SS, Yarden Y: An immunological approach reveals biological differences between the two NDF/heregulin receptors. ErbB-3 and ErbB-4. J Biol Chem 271: 7620-7629, 1996
36. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, et al.: Induction of apoptosis in fibroblasts by c-myc protein. Cell 59: 119-128, 1992