Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 11, 1998, Pages 1993-2011

  Nadler, Guy ^a   Faivre, Jean François ^a   Forest, Marie Claire ^a   Cheval, Brigitte ^a   Martin, Michel ^a   Souchet, Michel ^a   Gout, Bernard ^a   Bril, Antoine ^a  

^a SmithKline Beecham Laboratoires P   (France)

Author keywords

Antiarrhythmic; Calcium channel; Class III; Class IV; Potassium channel

Indexed keywords

ANTIARRHYTHMIC AGENT; N (3,4 DIMETHOXYPHENYL) N [3 [[2 (3,4 DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL] 4 NITROBENZAMIDE DERIVATIVE; N (3,4 DIMETHOXYPHENYL) N [3 [[2 (3,4 DIMETHOXYPHENYL)ETHYL]PROPYL] 4 NITROBENZAMIDE]; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; DRUG SYNTHESIS; GUINEA PIG; HEART ARRHYTHMIA; HEART PAPILLARY MUSCLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POTASSIUM CURRENT; REPOLARIZATION; STRUCTURE ACTIVITY RELATION;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZAMIDES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DELAYED RECTIFIER POTASSIUM CHANNELS; ELECTROPHYSIOLOGY; GUINEA PIGS; HYDROGEN BONDING; INDICATORS AND REAGENTS; MOLECULAR STRUCTURE; PAPILLARY MUSCLES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031767060     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00166-7     Document Type: Article

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