Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

British Journal of Pharmacology

Volumn 125, Issue 7, 1998, Pages 1511-1516

  Baydoun, Anwar R ^a,b   Morgan, David M L ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

Bacterial lipopolysaccharide; Inducible nitric oxide synthase; Macrophages; Nitric oxide; Ornithine decarboxylase; Polyamines; difluoromethylornithine

Indexed keywords

ARGININE; BACTERIUM LIPOPOLYSACCHARIDE; CITRULLINE; EGTAZIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; ORNITHINE DECARBOXYLASE; PUTRESCINE; SPERMIDINE; SPERMINE;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME INHIBITION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM;

EID: 0031766007     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702231     Document Type: Article

References (32)

1. ALHONEN-HONGISTO, L., HIRVONEN, A., SINERVIRTA, R. & JANNE, J. (1987). Cadaverine supplementation during a chronic exposure to difluoromethylornithine allows an overexpression. but prevents gene amplification of ornithine decarboxylase in L1210 mouse leukaemia cells. Biochem. J., 247, 651-655.
2. ALHONEN-HONGISTO, L., KALLIO, A., SINERVIRAT, R., SEPPANEN, P., KONTULA, K.K., JANNE, O.A. & JANNE, J. (1985). Difluoromethylornithine-induced amplification of ornithine decarboxylase gene in Ehrlich ascites carcinoma cells. Biochem. Biophys. Res. Commun., 126, 734-740.
3. ASSREUY, J., CUNHA, F.Y., LIEW, F.Y. & MONCADA, S. (1993). Feedback inhibition of nitric oxide synthase activity by nitric oxide. Br. J. Pharmacol., 108, 833-837.
4. BLASCHKO, H. (1962). The amine oxidases of mammalian blood plasma. Adv. Comp. Physiol. Biochem., 1, 67-116.
5. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
6. BROWN, J.L., TEPPERMAN, B.L., HANSON, P.J., WHITTLE, B.J.R. & MONCADA, S. (1992). Differential distribution of nitric oxide synthase between cell fractions isolated from the rat gastric mucosa. Biochem. Biophys. Res. Commun., 184, 680-685.
7. 1-acetyltransferase: the turning point in polyamine metabolism. FASEB J., 7, 653-661.
8. CIRINO, G., WHEELER-JONES, C.P.D., WALLACE, J.L., DEL SOLDATO, P. & BAYDOUN, A.R. (1996). Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties. Br. J. Pharmacol., 117, 1421-1426.
9. GALEA, E., REGUNATHAN, S., ELIOPOULOS, V., FEINSTEIN, D.L. & REIS, D.J. (1996). Inhibition of mammalian nitric oxide synthases by agmatin, an endogenous polyamine formed by decarboxylation of arginine. Biochem. J., 316, 247-249.
10. 15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138.
11. HARPER, J.F. (1984). Peritz F test: BASIC program of a robust multiple comparison test for statistical analysis of all differences among group means. Comput. Biol. Med., 14, 437-445.
12. HAYASHI, S. (1989). Multiple mechanisms for the regulation of mammalian ornithine decarboxylase. In Ornithine Decarboxylase: Biology, Enzymology, and Molecular Genetics, ed. Hayashi, S. pp.35-43. Oxford: Pergamon Press.
13. HU, J., MAHMOUD, M.I. & EL-FAKAHANY, E.E. (1994). Polyamines inhibit nitric oxide synthase in rat cerebellum. Neurosci. Lett., 175, 41-45.
14. JÄNNE, J., ALHONEN, L. & LEIONEN., P. (1991). Polyamines: from molecular biology to clinical applications. Ann. Med., 23, 241-259.
15. LACHENBRUCH, P.A. (1983). Statistical programs for microcomputers. Byte. 8, 560-570.
16. LEINONEN, P., ALHONEN-HONGISTO, L., LAINE, R.A.U., JANNE, O.A. & JANNE, J. (1987). Human myeloma cells acquire resistance to diflurormethylornithine by amplification of ornithine decarboxylase gene. Biochem. J., 242, 199-203.
17. MAMONT, P.S., DUCHESNE, M.-C., GROVE, J. & BEY, P. (1978). Antiproliferative properties of DL-α-difluoromethylornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase. Biochem. Biophys. Res. Commun., 81, 58-66.
18. MCCANN, P.P. & PEGG, A.E. (1992). Ornithine decarboxylase as an enzyme target for therapy. Pharmacol. Ther., 54, 195-215
19. MORGAN, D.M.L. (1987a). Polyamines. Essays Biochem., 23, 82-115.
20. MORGAN, D.M.I., (1987b). Oxidised polyamines and the growth of vascular endothelial cells: prevention of cytotoxic effects by selective acetylation. Biochem. J., 242, 347-352.
21. MORGAN, D.M.L. (1989). Polyamine oxidase and oxidised polyamines. In Physiology of the Polyamines. eds. Bachrach, U. & Heimer, Y. vol. 1, pp. 203-229. Boca Raton FL: CRC Press.
22. MORGAN, D.M.L. (1990). Polyamines and cellular regulation: perspectives. Biochem. Soc. Trans., 18, 1080-1084.
23. MORGAN, D.M.L. (1994) Difluoromethylornithine (DFMO), an inhibitor of nitrite production by macrophages? Biochem. Soc. Trans., 22, 389S.
24. MOSSMAN, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
25. PEGG, A.E. (1986). Recent advances in the biochemistry of polyamines in eukaryotes. Biochem. J., 234, 249-262.
26. POULIN, R., LU., L., ACKERMANN, B., BYE, P. & PEGG, A.E. (1992). Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by α-difluoromethylornithine. J. Biol. Chem., 267, 150-158.
27. SEILER, N., DELCROS J.G. & MOULINOUX J.P. (1996). Polyamine transport in mammalian cells an update. Int. J. Biochem. Cell Biol., 28, 843-861.
28. SEILER, N. & DEZEURE, F. (1990). Polyamine transport in mammalian cells. Int. J. Biochem., 22, 211-211.
29. SZABO, C., SOUTHAN, G.J., THIEMERMANN, C. & VANE, J.R. (1994a). The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. Br. J. Pharmacol., 113, 757-766.
30. SZABO, C., SOUTHAN, G.J., WOOD, E., THIEMERMANN, C. & VANE, J.R. (1994b). Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor. Br. J. Pharmacol., 112, 355-356.
31. TJANDRAWINATA, R.R., HAWEL III, L. & BYUS, C.V. (1994). Regulation of putrescine export in lipopolysaccharide or IFN-γ activated murine monocytic-leukemic RAW 264 cells. J. Immunol., 152, 3039-3052.
32. WILSON, S.R. (1983). Benchmark data sets for the flexible evaluation of statistical software. Comp. Statist. Data Anal., 1, 29-39.