Poly(DL-lactic acid) as a direct compression excipient in controlled release tablets. Part I. Compaction behaviour and release characteristics of poly(DL-lactic acid) matrix tablets

International Journal of Pharmaceutics

Volumn 175, Issue 1, 1998, Pages 33-46

  Steendam, R ^a   Lerk, C F ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Compaction speed; Controlled release; Direct compression; Matrix tablets; Poly(DL lactic acid); Porosity

Indexed keywords

EXCIPIENT; MAGNESIUM STEARATE; POLYLACTIC ACID;

ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG RELEASE; MATRIX TABLET; PH; PRESSURE; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION; TABLET COMPRESSION; TABLET FORMULATION; TENSILE STRENGTH;

EID: 0031765206     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00242-7     Document Type: Article

References (28)

1. Armstrong, N., 1997. Selection of excipients for direct compression tablet formulations. Pharm. Tech. Eur. 9, 24-30.
2. Avgoustakis, K., Nixon, J.R., 1993a. Biodegradable controlled release tablets: II. Preparation and properties of poly(lactide-co-glycolide) powders. Int. J. Pharm. 99, 239-246.
3. Avgoustakis, K., Nixon, J.R., 1993b. Biodegradable controlled release tablets: III. Effect of polymer characteristics on drug release from heterogeneous poly(lactide-co-glycolide) matrices. Int. J. Pharm. 99, 247-252.
4. Chang, K.T., Coffin, M.D., McGinity, J.W., 1987. Properties of controlled-release matrix tablets containing DL-polylactic acid as the retardant polymer. J. Pharm. Sci. 76, S259.
5. Coffin, M.D., Bodmeier, R., Chang, K.T., McGinity, J.W., 1987. The preparation, characterization and evaluation of poly(DL-lactide) aqueous latices. J. Pharm. Sci. 76, S261.
6. Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L.H., Langer, R., 1991. Controlled delivery system for proteins based on poly(lactic/glycolic acid) microspheres. Pharm. Res. 8, 713-720.
7. Cutright, D.E., Hansuck, E.E., 1972. The repair of fractures of the orbital floor using biodegradable polylactic acid. Oral Surg. 33, 28-34.
8. Cutright, D.E., Beasley, J.D., Perez, B., 1971. Histologic comparison of polylactic and polyglycolic acid sutures. Oral Surg. 32, 165-173.
9. Duckworth, W.H., 1953. Discussion of Ryshkewitch paper by Winston Duckworth. J. Am. Ceram. Soc. 36, 68.
10. Fell, J.T., Newton, J.M., 1971. Effect of particle size and speed of compaction on density changes in tablets of crystalline and spry-dried lactose. J. Pharm. Sci. 60, 1866-1869.
11. Grypma, D.W., 1993. High impact strength poly(lactide) tough biodegradable materials. Ph.D Thesis, University of Groningen, The Netherlands.
12. Heckel, R.W., 1961a. Density pressure relationship in powder compaction. Trans. Met. Soc. AIME 221, 671-675.
13. Heckel, R.W., 1961b. An analysis of powder compaction phenomena. Trans. Met. Soc. AIME 221, 1001-1008.
14. Higuchi, T., 1963. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52, 1145-1149.
15. Jalil, R., Nixon, J.R., 1990. Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties. J. Microencapsulation 7, 297-325.
16. Mank, R., Kala, H., Richter, M., 1989a. Darstellung peroraler Retardarzneiformen auf der Basis von biologisch abbaubaren Polymeren. I. Mitteilung: Darstellung und Charakterisierung von Polymilchsäure. Pharmazie 44, 276-279.
17. Mank, R., Kala, H., Richter, M., 1989b. Darstellung peroraler Retardarzneiformen auf der Basis von biologisch abbaubaren Polymeren. 2. Mitteilung: Darstellung von Matrixtabletten auf der Basis von Polymilchsäure. Pharmazie 44, 328-330.
18. Moll, F., Köller, G., 1990. Biodegradable tablets having a matrix of low-molecular weight poly-L-lactic acid and poly-DL-lactic acid. Arch. Pharm. 323, 887-888.
19. Omelczuk, M.O., McGinity, J.W., 1992. The influence of polymer glass transition and molecular weight on drug release from tablets containing poly(DL-lactic acid). Pharm. Res. 9, 26-32.
20. Omelczuk, M.O., McGinity, J.W., 1993. The influence of thermal treatment on the physical-mechanical and dissolution properties of tablets containing poly(DL-lactic acid). Pharm. Res. 10, 542-548.
21. Omelczuk, M.O., McGinity, J.W., 1995. A comparative investigation of the compaction and dissolution properties of tablets containing poly(DL-lactic acid) as a binder and retardant polymer. S.T.P. Pharm. Sci. 5, 181-186.
22. Paronen, T.P., Peltonen, S.H., Urtti, A.O., Nakari, L.J., 1995. Starch acetate composition with modifiable properties, method for preparation and usage thereof. Finland patent WO 95/33450, 14 December.
23. Roberts, R.J., Rowe, R.C., 1985. The effect of punch velocity on the compaction of a variety of materials. J. Pharm. Pharmacol. 37, 377-384.
24. Stamm, A., Mathis, C., 1976. Verpressbarkeit von festen Hilfsstoffen fuer Direkttablettierung. Acta Pharm. Tech. Suppl. 1, 7-16.
25. Van der Voort Maarschalk, K., 1997. Tablet relaxation. Origin and consequences of stress relief in tablet formation. Thesis, University of Groningen, The Netherlands.
26. Van der Voort Maarschalk, K., Vromans, H., Bolhuis, G.K., Lerk, C.F., 1996. The effect of viscoelasticity and tabletting speed on consolidation and relaxation of a viscoelastic material. Eur. J. Pharm. Biopharm. 42, 49-55.
27. Vromans, H., 1987. Studies on consolidation and compaction of lactose. Ph.D Thesis, University of Groningen, The Netherlands.
28. Yamakawa, I., Kawahara, M., Watanaba, S., Miyake, Y., 1989. Sustained release of insulin by double-layered implant using poly(DL-lactic acid). J. Pharm. Sci. 79, 505-509.