Analysis of human immune response to potential hepatitis C viral epitopes

Acta Virologica

Volumn 42, Issue 3, 1998, Pages 141-145

  Khanna, A ^a   Poduri, C D ^a   Murugan, P ^a   Kumar, S ^a   Sugunan, V S ^a   Shenoy, K T ^b   Das, M R ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^b Medical College Hospital Thiruvananthapuram   (India)

Author keywords

Antibodies; ELISA; Epitopes; Hepatitis C virus; Peptide based immunoassay; RT PCR; Synthetic peptides

Indexed keywords

CORE PROTEIN; SYNTHETIC PEPTIDE; VIRUS ENVELOPE PROTEIN;

ACUTE PHASE RESPONSE; AMINO ACID SEQUENCE; ANTIBODY DETECTION; ARTICLE; DIAGNOSTIC ACCURACY; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; VIRUS GENOME;

AMINO ACID SEQUENCE; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIBODIES; HEPATITIS C ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER DISEASES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SENSITIVITY AND SPECIFICITY;

HEPATITIS C VIRUS;

EID: 0031764106     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Blanchi E, Steinkuhler C, Taliani M, Urbani A, De Francesco R, Pessi A (1996): Synthetic Depsipeptide substrates for the assay of human HCV protease. Anal. Biochem. 237, 239-244.
2. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M (1989): Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359.
3. Das MR, Naushad Ali, Aruna B, Rama Durga, Nambiar A, Rehana Z, Shekhar MS, Siddiqui A, Habibullah CM (1993): Indian strains of hepatitis-C-virus: Prevalence and detection. Curr. Sci. 65(6), 477-483.
4. Grakoui A, McCourt D, Wychowski C, Feinstone S, Rice CM (1993): A second hepatitis C virus-encoded proteinase. Proc. Natl. Acad. Sci. USA 90, 10583-10587.
5. Johnson PJ, McFarlane IG, Alvarez F et al. (1993): Meeting report. International auto immune hepatitis group. Hepatology 18, 998.
6. Kotwal GJ, Baroudy BM, Kuramoto IK et al. (1992): Detection of acute hepatitis C virus infection by ELISA using a synthetic peptide comprising a structural epitope. Proc. Natl. Acad. Sci. USA 89, 4486-4489.
7. McHutchinson JG, Person JL, Govindarajan S et al. (1992): Improved detection of hepatitis C virus antibodies in high - risk populations. Hepatology 15, 19-25.
8. Magrin S, Craxi A, Fiorentino G et al (1991): Is auto immune chronic active hepatitis a HCV related disease? J. Hepatol. 13, 56.
9. Rosa D, Campagnoli S, Moretto C et al. (1996): A quantitative test to estimate neutralising antibodies to the hepatitis C virus: Cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl. Acad. Sci. USA 93, 1759-1763.
10. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanbe Y, Koi S, Onji M, OhtaY, Choo QL, Houghton M, Kuo G (1990): Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87, 6547-6549.
11. Simmonds P, Rose KA, Graham S et al. (1993a): Mapping of serotype specific, immunodominant epitopes in the NS4 region of hepatitis C virus: Use of type - specific peptides to serologically differentiate infections with HCV types 1, 2, and 3. J. Clin. Microbiol. 31, 1493-1503.
12. Simmonds P, Holmes EC, Cha T-A et al. (1993b): Classification of HCV into six major genotypes and a series of subtypes by phylogenetic analysis of the NS5 region. J. Gen. Virol. 74, 2391-2399.
13. Sugitano M, Inchauspe G, Shindo M, Prince AM (1992): Sensitivity of serological assays to identify blood donors with hepatitis C viraemia. Lancet 339, 1018-1019.
14. van der Poel CL, Cuypers HT, Reesinck HW et al. (1991): Confirmation hepatitis C virus infection by new four antigen recombinant immunoblot assay. Lancet 337, 317.
15. Wang CY (1988a): In Mizrahi A (Ed.): Advances in Biotechnological Processes. Liss, New York, 10, 131-148.
16. Wang CY, Wang JG (1988b): US patent 4, 735, 896.
17. Wang CY, Wang JG (1989a): US patent 4, 879, 212.
18. Wang CY, Wang JG, Walters DW (1989b): US patent 4, 833, 071.
19. Weiner AJ, Kuo G, Bradley DW (1990): Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet 335, 1.
20. Yuki N, Hayashi N, Hagiwara H et al. (1992): HCV RNA and antibody to HCV core protein in Japanese patients with chronic liver disease. Dig. Dis. Sci. 37, 1483-1488.
21. Yuki N, Hayashi N, Hagiwara H et al. (1993): Serodiagnosis of chronic hepatitis C in Japan by second generation recombinant immunoblot assay. J. Hepatol. 17, 170-174.
22. Yuki N, Hayashi N, Mita E et al. (1995): Clinical characteristics and antibody profiles of chronic hepatitis C patients: relation to hepatitis C virus genotypes. J. Med. Virol. 45, 162-167.
23. Zhu-Xu Zhang, Margaret Chen, Anders Sonnerborg, Ola Weiland, Matti Sallberg (1995): Distinguishing acute from symptomatic chronic HCV infection by site-directed serology of the HCV structural proteins. J. Infect. Dis. 171, 1356-59.