Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line

Endocrinology

Volumn 139, Issue 2, 1998, Pages 626-633

  Colantonio, Concettina M ^a,b   Kwan, Wai King ^a   Czerwinski, Waldemar ^a   Mitchell, Jane ^b   Schimmer, Bernard P ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ADRENAL CORTEX TUMOR; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL MUTANT; CONTROLLED STUDY; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR AFFINITY; TUMOR CELL LINE;

EID: 0031763640     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.2.5755     Document Type: Article

References (36)

1. Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ 1991 Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem 60:653-688
2. Bohm SK, Grady EF, Bunnett NW 1997 Regulatory mechanisms that modulate signalling by G-protein-coupled receptors. Biochem J 322:1-18
3. Mumby SM, Kleuss C, Gilman AG 1994 Receptor regulation of G-protein palmitoylation. Proc Natl Acad Sci USA 91:2800-2804
4. Houslay MD 1991 'Crosstalk:' a pivotal role for protein kinase C in modulating relationships between signal transduction pathways. J Biol Chem 264:8802-8810
5. Milligan G 1993 Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications. Trends Pharmacol Sci 14:413-418
6. Wedegaertner PB, Bourne HR 1994 Activation and depalmitoylation of GSα, Cell 77:1063-1070
7. Milligan G, Wise A, MacEwan DJ, Grassie MA, Kennedy FR, Lee TW, Adie EJ, Kim GD, McCallum JF, Burt A 1995 Mechanisms of agonist-induced G-protein elimination. Biochem Soc Trans 23:166-170
8. Dohlman HG, Song J, Ma D, Courchesne WE, Thorner J 1996 Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization and genetic interaction and physical association with Gpal (the G-protein α subunit). Mol Cell Biol 16:5149-5209
9. Neill JD, Duck LW, Sellers JC, Musgrove LC, Scheschonka A, Druey KM, Kehrl JH 1997 Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization. Endocrinology 138:843-846
10. Watt VM, Schimmer BP 1982 Clonal variation in adrenocorticotropin-induced desensitization of adenylate cyclase in Y1 adrenocortical tumor cells. J Biol Chem 257:1684-1689
11. Olson MF, Tsao J, Pon DJ, Schimmer BP 1991 Regulation of adenylyl cyclase activity by β-adrenergic agonists in a desensitization-resistant mutant cell line. Mol Endocrinol 5:34-41
12. 1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant. Mol Endocrinol 6:1095-1102
13. Olson MF, Schimmer BP 1994 Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells. Endocrinology 134:7-10
14. Robishaw JD, Smigel MD, Gilman AG 1986 Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem 261:9587-9590
15. Bourne H, Coffino P, Tomkins GM 1975 Somatic genetic analysis of cyclic AMP action: characterization of unresponsive mutants. J Cell Physiol 85:611-620
16. Munson PJ, Rodbard D 1980 LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239
17. Ross EM, Gilman AG 1977 Reconstitution of catecholamine-sensitive adenylate cyclase activity: interaction of solubilized components with receptor-replete membranes. Proc Natl Acad Sci USA 74:3715-3719
18. Mumby SM, Gilman AG 1991 Synthetic peptide antisera with determined specificity for G protein α and β subunits. Methods Enzymol 195:215-232
19. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299
20. Sullivan KA, Liao Y, Alborzi A, Beiderman B, Chang F, Masters SB, Levinson AD, Bourne HR 1986 Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid seuqences of the α chains. Proc Natl Acad Sci USA 83:6687-6691
21. D'Aquila RT, Bechtel LJ, Videler JA, Eron JJ, Gorczyca P, Kaplan JC 1991 Maximizing sensitivity and specificity of PCR by preamplification heating. Nucleic Acids Res 19:3749
22. Frohman MA, Dush MK, Martin GR 1988 Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc Natl Acad Sci USA 85:8998-9002
23. Sanger F, Nicklen S, Coulson AR 1977 DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
24. Stadel JM, DeLean A, Lefkowitz RJ 1982 Molecular mechanisms of coupling in hormone-receptor-adenylate cyclase systems. Adv Enzymol 53:1-43
25. s-deficient membranes. Naunyn Schmiedebergs Arch Pharmacol 333:124-129
26. 2-adrenergic receptors by sodium. J Biol Chem 265:21590-21595
27. Costa T, Lang J, Gless C, Herz A 1989 Spontaneous association between opiod receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions. Mol Pharmacol 37:383-394
28. Higashijima T, Ferguson KM, Sternweis PC 1987 Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride. J Biol Chem 262:3597-3602
29. Rail T, Harris BA 1987 Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma. FEBS Lett 224:365-371
30. s signal transduction protein. Proc Natl Acad Sci USA 83:8893-8897
31. Maguire ME, Ross EM, Gilman AG 1977 β-Adrenergic receptor: ligand binding properties and the interaction with adenylyl cyclase. Adv Cyclic Nucleotide Res 8:1-82
32. Kent RS, Lean A, Lefkowitz RJ 1980 A quantitative analysis of beta-aderenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data. Mol Pharmacol 17:14-23
33. + modulate receptor-adenyl cyclase coupling and receptor-mediated function. Am J Physiol 247:E59-E68
34. 2-adrenergic receptor and rhodopsin systems. J Biol Chem 267:8558-8564
35. Mitchell J, Goltzman D 1990 Mechanisms of homologous and heterologous desensitization of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106. Endocrinology 126:2650-2660
36. Harper J 1984 Peritz's F test: basic program of a robust multiple comparison test for statistical analysis of all differences among group means. Comput Biol Med 14:437-445