Reduced levels of testosterone and dehydroepiandrosterone sulphate in the serum and synovial fluid of juvenile rheumatoid arthritis patients correlates with disease severity

Clinical and Experimental Rheumatology

Volumn 16, Issue 6, 1998, Pages 753-756

  Khalkhali Ellisl, Z ^a,b,c   Moore, T L ^a,b,c   Hendrixl, M J C ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b Division of Rheumatology   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dehydroepiandrosterone sulphate; Estrogen; Juvenile rheumatoid arthritis; Progesterone; Synovial fluid; Testosterone

Indexed keywords

ESTRADIOL; GOLD; HYDROXYCHLOROQUINE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PRASTERONE; TESTOSTERONE;

ADOLESCENT; ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG SYNOVIAL FLUID LEVEL; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; JUVENILE RHEUMATOID ARTHRITIS; MALE; PATHOGENESIS; PRIORITY JOURNAL;

ADOLESCENT; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; CHILD, PRESCHOOL; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; ESTRADIOL; FEMALE; HUMANS; MALE; PROGESTERONE; PUBERTY; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID; TESTOSTERONE;

EID: 0031763636     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. CUTOLO M, BALLEARI E, ACCARDO S et al.: Preliminary results of serum androgen testing in men with rheumatoid arthritis. Arthritis Rheum 1984; 27: 958-9.
2. SPECTORTD,PERRYLA,TUBBG,SILMANAJ, HUSK1SSON EC: Low free testosterone levels in 276 males: A comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls. Clin Rlmimatol 1989; 8:3741.
3. FEHER KG, FEHER T, MERETY K: Inter-relationship between the immunological and steroid hormone parameters in rheumatoid arthritis. Exp Clin Endocrinol 1986; 87:38-42.
4. CUTOLO M, BALLEARI E, GIUSTI M, SAMANTA E, MONACHESI M, ACCARDO S: Sex hormone status in women suffering from rheumatoid arthritis. J Rheumatol 1986; 13: 1019-23.
5. MASI AT, CHATTERTON RT, COMSTOCK GW, MALAMET RL, HOCHBERG MC: Decreased androgenic-anabolic hormone levels in sera of white women before the onset of RA: A controlled prospective study. Arthritis Rheum 1993,36: S176.
6. ATHREYA, BH, RAFFERTY JH, SEHGAL GS, LAHITA RG: Adenohypophyseal and sex hormones in pédiatrie rheumatic diseases../Rheumatol 1993; 20:725-30.
7. MCMURRAY RW, ALLEN su, PEPMUELLER PH, KEISLERT D, CASSIDY JT: Elevated serum prolactin levels in children with juvenile rheumatoid arthritis and antinuclear antibody seropositivity. J Rheumatol 1995; 22: 157780.
8. KULLICH W, KLEIN G: Possible effect of hormones on immune and inflammatory processes in female patients with chronic polyarthritis.ctoMedicoAustriaca 1996; 23:11923.
9. DEIGHTON CM, WATSON. MJ, WALKER DJ: Sex hormones in post menopausal HLA-identical rheumatoid arthritis discordant sibling puts. J Rheumatol 1992; 19: 1663-7.
10. HENNEBOLD JD, DAYNES RA: Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 1994; 135: 67-75.
11. HEDMAN M, NILSSON E, DE LA TORRE B: Low blood and synovial fluid levels of sulpho-conjugated steroids in rheumatoid arthritis. Clin Exp Rheumatol 1992; 10: 25-30.
12. PARKER LN, LEVIN ER, LIFRAK ET: Evidence for adrenocortical adaptation to severe illness. J Clin Endocrinol Melab 1985; 60: 671-9.
13. HEDMAN M, NILSSON E, DE LA TORRE B: Low sulpho-conjugated steroid hormone levels in systemic lupus erythematosus (SLE). Clin Exp Rheumatol 1989; 7: 583-8.
14. NILSSON E, DE LA TORRE B, HEDMAN M, GOOBAR J, THORNER A: Blood dehydroepiandrosterone sulphate (DHEAS) levels in polymyalgia rheumatica/giant cell arteritis and primary fibromyalgia. Clin Exp Rheumatol 1994; 12: 415-7.
15. DASILVAJA,LARBREJP.SPECTORTD,PERRY LA, SCOTT DL, WILLOUGHBY DA: Protective effect of androgens against inflammation induced cartilage degradation in male rodents. Annals Rheum Dis 1993; 52: 285-91.