Insulin and IGF binding by IGFBP-3 fragments derived from proteolysis, baculovirus expression and normal human urine

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 4, 1998, Pages 1392-1395

  Vorwerk, Peter ^a   Yamanaka, Yoshitaka ^a   Spagnoli, Anna ^a   Oh, Youngman ^a   Rosenfeld, Ron G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; IODINE 125; MONOCLONAL ANTIBODY; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN 3;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BACULOVIRUS; CELL STRAIN 3T3; GENE OVEREXPRESSION; HORMONE RECEPTOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECEPTOR BINDING; URINE;

ANIMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0031762905     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.83.4.4858     Document Type: Article

References (21)

1. Jones JI, Clemmons DR: Insulin-like growth factos and their binding proteins: Biological actions. Endocr Rev. 1995; 16 3-34
2. Oh Y, Mueller HL, Lamson G, Rosenfeld RG: Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. J Biol Chem. 1993; 268: 14964-14971
3. Giudice LC, Farrell EM, Pham H, Lamson G, Rosenfeld RG: Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity. J Clin Endocrinol Metab. 1990; 71: 806-816.
4. Hossenlopp P, Segovia B, Lassarre C, Roghanl M, Bredon M, Binoux M: Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy. J Clin Endocrinol Metab. 1990; 71: 797-805.
5. Gargosky SE, Pham HM, Wilson KF, Uu F, Guidice LC, Rosenfeld RG: Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. Endocrinology. 1992; 131: 3051-3060.
6. Bang P, Fielder PJ: Human pregnancy serum contains at least two distinct proteolytic activities with the ability to degrade insulin-like growth factor binding protein-3. Endocrinology. 1997; 138: 3912-3917
7. Cohen P, Graves HCB, Peehl DM, Kamarei M, Guidice LC, Rosenfeld RG: Prostate-specific antigen is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992; 75: 1046-1053
8. Campbell PG, Novak JF, Yanosick TB, McMaster JH: Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex. Endocrinology. 1992;1401-1412
9. Fielder PJ, Rosenfeld RG, Gaves HCB, Grandbois K, Maack CA, Sawamura S, Sommer A, Cohen P: Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3. Growth Regulation. 1994; 1: 164-172
10. Fowlkes JL, Enghild JJ, Suzuki K, Nagase H: Matrix metalloproteinases degrade insulin-like growth factor binding protein-3 in dermal fibroblast cultures. J Biol Chem. 1994; 269: 25742-25746.
11. Lalou C, Lassarre C, Binoux M: A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGFs inhibits the mitogenic effects of IGF-I and insulin. Endocrinology. 1996; 137: 3206-3212.
12. Booth BA, Boes M, Bar RS: IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments. Am J Physiol. (Endocrinol Metab.) 1996; 34: E 465-E470
13. Oh, Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG: Synthesis and characterization of insulin-like growth factor biding protein (IGFBP)-7. 1996 J Biol Chem. 271, 30322-30325
14. Wilson E, Oh Y, Rosenfeld R: Generation and characterization of an IGFBP-7 antibody. J Clin Endocrinol Metab. 1997; 82: 1301-1303
15. Bereket A, Lang CH, Belethen SL, Fan J, Frost RA, Wilson TA: Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity. J Clin Endocrinol Metab. 1995; 80: 2282-2288
16. Vorwerk P, Oh Y, Lee PDK, Khare A, Rosenfeld RG: Synthesis of IGFBP-3 fragments in a baculovirus system and characterization of monoclonal anti-IGFBP-3 antibodies. J Clin Endocrinol Metab. 1997; 82: 1301-1303
17. Op de Beeck L, Verlooy JEA, Van Buul-Offers SC, Du Caju MVL: Detection of serum insulin-like growth factor binding proteins on western ligand blots by biotinylated IGF and enhanced chemiluminescence. J Endocrinol. 1997; 154: R1-R5.
18. Yamanaka Y, Rosenfeld RG Wilson E, Oh Y: Inhibition of insulin receptor activation by insulin-like growth factor binding proteins. J Biol Chem. 1997: 272: 30729-30734
19. Wood WI, Cachianes G, Henzel WJ, Winslow GA, Spencer SA, Hellmiss R, Martin JL, Baxter RC: Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein. Mol Endocrinol 1988; 2: 1176-1185.
20. Spagnoli A, Gargosky SE, Spadoni GL, Macgillivray, Oh Y, Boscherini B, Rosenfeld RG: Characterization of a low molecular mass form of insulin-like growth factor binding protein-3 (17.7 kilodaltons) in urine and serum from healthy children and growth hormone (GH)-deficient patients. J Clin Endocrinol Metab. 1995; 80: 3668-3675
21. Zadeh SM, Binoux M: The 16 kDa proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 inhibits the mitogenic action of fibroblast growth factor on mouse fibroblasts with a target disruption of the type 1 IGF receptor gene. Endocrinology. 1997; 138: 3069-3072