Megestrol acetate antagonizes cisplatin cytotoxicity

Anti-Cancer Drugs

Volumn 9, Issue 8, 1998, Pages 733-738

  Pu, Yeong Shiau ^a,b   Cheng, Ann Lii ^a   Chen, Jun ^a   Guan, Jing Yi ^a   Lu, Shiu Hui ^a   Lai, Ming Kuen ^a   Hsieh, Chang Yao ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cisplatin; Drug treatment; Megestrol acetate; Transitional carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GESTAGEN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MEGESTROL ACETATE; METALLOTHIONEIN;

APPETITE; ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DRUG ANTAGONISM; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORTHERN BLOTTING; PRIORITY JOURNAL; TRANSITIONAL CELL CARCINOMA;

ANTINEOPLASTIC AGENTS; APPETITE STIMULANTS; CARCINOMA; CISPLATIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; MEGESTROL ACETATE; METALLOTHIONEIN; TUMOR CELLS, CULTURED;

EID: 0031762567     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199809000-00009     Document Type: Article

References (18)

1. Osoba D, Murray N, Gelmon K, et al. Quality of life, appetite, and weight change in patients receiving dose-intensive chemotherapy. Oncology 1994; 8: 61-5.
2. Nathanson L, Meelu MA, Losada R. Chemohormone therapy of metastatic melanoma with megestrol acetate plus dacarbazine, carmustine, and cisplatin. Cancer 1994; 73: 98-102.
3. Rowland KM, Jr., Loprinzi CL, Shaw EG, et al. Randomized double-blind placebo-controlled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensive-stage small-cell lung cancer: a North Central Cancer Treatment Group study. J Clin Oncol 1996; 14: 135-41.
4. Yang YY, Woo ES, Reese CE, Bahnson RR, Saijo N, Lazo JS. Human metallothionein isoform gene expression in cisplatin-sensitive and resistant cells. Mol Pharmacol 1994; 45: 453-60.
5. Kotoh S, Naito S, Sakamoto N, Goto K, Kumazawa J. Metallothionein expression is correlated with cisplatin resistance in transitional cell carcinoma of the urinary tract. J Urol 1994; 152: 1267-70.
6. Ahn H, Lee E, Kim K, Lee C. Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines. J Urol 1994; 151: 263-7.
7. Bai F, Nakanishi Y, Kawasaki M, et al. Immunohisto chemical expression of glutathione S-transferase-π can predict chemotherapy response in patients with nonsmall cell lung carcinoma. Cancer 1996; 78: 416-21.
8. Goto S, Yoshida K, Morikawa T, Urata Y, Suzuki K, Kondo T. Augmentation of transport for cisplatin-glutathione adduct in cisplatin-resistant cancer cells. Cancer Res 1995; 55: 4297-301.
9. Cascinu S, Cordella L, Del Ferro E, Fronzoni M, Catalano G. Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial. J Clin Oncol 1995; 13: 26-32.
10. Yu HJ, Tsai TC, Hsieh TS, Chiu TY. Characterization of a newly established human bladder carcinoma cell line, NTUB1. J Formosan Med Ass 1992; 91: 608-13.
11. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987; 47: 936-42.
12. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22: 27-55.
13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.
14. Lion T, Haas OA. Nonradioactive labeling of probe with digoxigenin by polymerase chain reaction. Anal Biochem 1990; 188: 335-7.
15. Richards RI, Heguy A, Karin M. Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids. Cell 1984; 37: 263-72.
16. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350-4.
17. Panasci L, Jean-Claude BJ, Vasilescu D, et al. Sensitization to doxorubicin resistance in breast cancer cell lines by tamoxifen and megestrol acetate. Biochem Pharmacol 1996; 52: 1097-102.
18. Wood DP, Jr, Klein E, Fair WR, Chaganti RS. Metallothionein gene expression in bladder cancer exposed to cisplatin. Modern Pathol 1993; 6: 33-5.