Mechanisms of altered hemodynamic and metabolic responses to insulin in patients with insulin-dependent diabetes mellitus and autonomic dysfunction

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 2, 1998, Pages 468-475

  Makimattila S ^a   Mantysaari M ^b   Schlenzka, A ^a   Summanen, P ^a   Yki Jarvinen H ^a,c  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b CENTRAL MILITARY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADRENERGIC SYSTEM; ADULT; ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NEUROPATHY; CLINICAL ARTICLE; CONTROLLED STUDY; HEART RATE VARIABILITY; HEMODYNAMICS; HUMAN; HYPOTENSION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; SYMPATHETIC REFLEX; VASCULAR RESISTANCE; VASOCONSTRICTION;

ADOLESCENT; ADULT; ARM; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 1; DIABETIC NEUROPATHIES; HEART RATE; HEMODYNAMIC PROCESSES; HUMANS; INSULIN; MALE; MIDDLE AGED; VASCULAR RESISTANCE;

EID: 0031762377     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.2.468     Document Type: Article

References (45)

1. Baron AD, Brechtel G. 1993 Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol. 265:E61-E67.
2. Laakso M, Edelman SV, Brechtel G, Baron AD. 1990 Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. J Clin Invest. 85:1844-1852.
3. Utriainen T, Malmström R, Mäkimattila S, Yki-Järvinen H. 1995 Methodological aspects, dose-response characteristics and causes of interindividual variability of insulin regulation of limb blood flow in normal subjects. Diabetologia. 38:555-564.
4. Scott AR, Bennett T, MacDonald IA. 1988 Effects of hyperinsulinemia on the cardiovascular responses to graded hypovolemia in normal and diabetic subjects. Clin Sci. 75:85-92.
5. 15O]CO and positron emission tomography. Am J Physiol. 269:E1000-E1005.
6. Scherrer U, Vollenweider P, Randin D, Jéquier E, Nicod P, Tappy L. 1993 Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans. Circulation. 88:388-394.
7. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. 1991 Hyperinsulinemia produces both sympathetic neural activation and vasodilatation in normal humans. J Clin Invest. 87:2246-2252.
8. Baron AD, Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G. 1995 Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity, and responsiveness in lean humans. J Clin Invest. 96:786-792.
9. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. 1994 Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 94:2511-2515.
10. Page MM, Watkins PJ. 1976 Provocation of postural hypotension by insulin in diabetic autonomie neuropathy. Diabetes. 25:90-95.
11. Palmer K, Perkins JP, Smith RBW. 1977 Insulin aggravated postural hypotension. Aust NZ J Med. 7:161-162.
12. Takata S, Yamamoto M, Yagi S, Noto Y, Ikeda T, Hattori N. 1985 Peripheral circulatory effects of insulin in diabetes. Angiology. 36:110-115.
13. Porcellati F, Fanelli C, Bottini P, et al. 1993 Mechanisms of arterial hypotension after therapeutic dose of subcutaneous insulin in diabetic autonomie neuropathy. Diabetes. 42:1055-1064.
14. Meneilly GS, Elliot T, Bryer-Ash M, Floras JS. 1995 Insulin-mediated increase in blood flow is impaired in the elderly. J Clin Endocrinol Metab. 80:1899-1903.
15. Baron AD, Brechtel-Hook G, Johnson A, Hardin D. 1993 Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension. 21:129-135.
16. Yki-Järvinen H, Young A, Lamkin C, Foley JE. 1987 Kinetics of glucose disposal in whole body and across skeletal muscle in man. J Clin Invest. 79:1713-1719.
17. DeFronzo RA, Tobin JD, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-E223.
18. Steel M, Nolan C, Nankervis A, et al. 1993 Forearm arterial vascular responsiveness in insulin-dependent diabetic subjects. Diabetes Res Clin Pract. 21:127-136.
19. Bannister R, Mathias CJ, eds. 1992 Autonomic failure. A textbook of clinical disorders of the autonomic nervous system, 3rd ed. Oxford: Oxford University Press.
20. Akselrod S, Gordon D, Madwed JB, Sindman NC, Shannon DC, Cohen RJ. 1985 Hemodynamic regulation: investigation by spectral analysis. Am J Physiol. 249:H867-H875.
21. Furlan R, Guzzetti S, Crivellaro W, et al. 1990 Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation. 81:537-547.
22. Mäkimattila S, Mäntysaari M, Groop P-H, et al. 1997 Hyperreactivity to nitrovasodilators in forearm vasculature is related to autonomic dysfunction in IDDM. Circulation. 95:618-625.
23. Ziegler D, Laux G, Dannehl K, et al. 1992 Assessment of cardiovascular autonomic function: age-related normal ranges and reproducibility of spectral analysis, vector analysis, and standard tests of heart rate variation and blood pressure responses. Diabetic Med. 9:166-175.
24. Valensi P, Attali JR, Gagant S. 1993 Reproducibility of parameters for assessment of diabetic neuropathy. The French Group for Research and Study of Diabetic Neuropathy. Diabetic Med. 10:933-939.
25. American Diabetes Association. 1994 Standards of medical care for patients with diabetes mellitus. Diabetes Care. 17:616-623.
26. Klein R, Klein BEK, Magli YL. 1986 An alternative method of grading diabetic retinopathy. Ophthalmology. 93:1183-1187.
27. Early Treatment Diabetic Retinopathy Study Research group. 1991 Grading diabetic retinopathy from stereoscopic color fundus photographs - an extension of the modified Airlie House classification: ETDRS Report No. 10. Ophthalmology. 98:786-806.
28. Ewing DJ, Martyn CN, Young RJ, Clarke BF. 1985 The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care. 8:491-498.
29. Task Force of the European Society of Cardiology, North American Society of Pacing and Electrophysiology. 1996 Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation. 93:1043-1065.
30. Genovely H, Pfeifer MA. 1988 RR-variation: the autonomic test of choice in diabetes. Diabetes Metab Rev. 4:255-271.
31. Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ. 1981 Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science. 213:220-222.
32. Pomeranz B, Macaulay JB, Claudill MA, et al. 1985 Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 248:H151-H153.
33. Malliani A, Pagani M, Lombardi F, Cerutti S. 1991 Cardiovascular neural regulation explored in the frequency domain. Circulation. 84:482-492.
34. Guyton AC. 1986 Textbook of medical physiology, 7th ed. Philadelphia: Saunders.
35. Moorhouse JA, Carter SA, Doupe J. 1966 Vascular responses in diabetic peripheral neuropathy. Br Med J. 1:883-888.
36. Poston L, Taylor PD. 1995 Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci. 88:245-255.
37. Mäkimattila S, Virkamäki A, Groop P-H, et al. 1996 Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. Circulation. 94:1276-1282.
38. Wieling W. 1992 Non-invasive continuous recording of heart rate, and blood pressure in the evaluation of neurocardiovascular control. In: Bannister R, Mathias CJ, eds. Autonomic failure. A textbook of clinical disorders of the autonomic nervous system, 3rd ed. Oxford: Oxford University Press; 291-311.
39. Natali A, Bonadonna R, Santoro D, et al. 1994 Insulin resistance and vaso-dilation in essential hypertension. J Clin Invest. 94:1570-1576.
40. 18F]fluoro-deoxy-glucose and positron emission tomography. J Clin Invest. 97:1741-1747.
41. Balon TW, Nadler JL. 1994 Nitric oxide release is present from incubated skeletal muscle preparations. J Appl Physiol. 77:2519-2521.
42. Baron AD, Zhu J-S, Marshall S, Irsula O, Brechtel G, Keech C. 1995 Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats. Am J Physiol. 269:E709-E715.
43. Fedele D, Bellavere F, Cardone C, Ferri M, Crepaldi G. 1985 Improvement of cardiovascular autonomic reflexes after amelioration of metabolic control in insulin-dependent diabetic subjects with severe autonomic neuropathy. Horm Metab Res. 17:410-413.
44. Yki-Järvinen H. 1992 Glucose toxicity. Endocr Rev. 13:415-431.
45. Mäkimattila S, Virkamäki A, Malmström R, Utriainen T, Yki-Järvinen H. 1996 Insulin resistance in type I diabetes mellitus: a major role for reduced glucose extraction. J Clin Endocrinol Metab. 81:707-712.