Enhancement of fracture healing by mechanical and surgical intervention

Clinical Orthopaedics and Related Research

Volumn 355, Issue SUPPL., 1998, Pages

  Chao, Edmund Y S ^a,b   Inoue, Nozomu ^a   Elias, John J ^a   Aro, Hannu ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICS; BONE REMODELING; CLINICAL RESEARCH; CONFERENCE PAPER; CYTOLOGY; DISEASE CLASSIFICATION; EXPERIMENTAL MODEL; FRACTURE; FRACTURE EXTERNAL FIXATION; FRACTURE HEALING; HISTOLOGY; MECHANICAL STRESS; MOLECULAR DYNAMICS; OSTEOSYNTHESIS; OSTEOTOMY; PERIOSTEUM; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0031762082     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-199810001-00018     Document Type: Conference Paper

References (59)

1. Ament C, Hofer EP: On the importance of the osteogenic and vasculative factors in callus healing. Fifth Biennial Meeting of the International Society for Fracture Repair, September 18-21. Ottawa, Canada 4, 1996.
2. Aro HT, Chao EYS: Biomechanics of Fracture Fixation. In Mow VC, Hayes WC (eds). Basic Orthopaedic Biomechanics. New York, Raven Press 293-336, 1991.
3. Aro HT, Chao EYS: Bone healing patterns affected by loading, fracture fragment stability, fracture type, and fracture site compression. Clin Orthop 293:8-17, 1993.
4. Aro HT, Kelly PJ, Lewallen DG, Chao EYS: The effects of physiologic dynamic compression on bone healing under external fixation. Clin Orthop 256:260-273, 1990.
5. Aro HT, Wahner HT, Chao EYS: Healing patterns of transverse and oblique osteotomies in the canine tibia under external fixation. J Orthop Trauma 5:351-364, 1991.
6. Aro HT, Wippermann BW, Hodgson SF, Chao EYS: Internal remodeling of periosteal new bone during fracture healing. J Orthop Res 8:238-246, 1990.
7. Aro HT, Wippermann BW, Hodgson SF, et al: Prediction of properties of fracture callus by measurement of mineral density using micro-bone densitometry. J Bone Joint Surg 71A:1020-1030, 1989.
8. Bassett CAL, Herrmann I: Influence of oxygen concentration and mechanical factors on differentiation of connective tissue in vitro. Nature 190:460-161, 1961.
9. Bolander ME: Inducers of Osteogenesis. In Friedlaender GE, Goldberg VM (eds). Bone and Cartilage Allografts. Park Ridge, IL. American Academy of Orthopaedic Surgeons 75-83, 1991.
10. Brighton CT: Principles of fracture healing. Instr Course Lect 33:60-82, 1984.
11. Brighton CT, Okereke E, Pollack S, Clark CC: In vitro bone-cell response to a capacitively coupled electrical field: The role of field strength, pulse pattern, and duty cycle. Clin Orthop 285:255-262, 1992.
12. Buckwalter JA, Woo SL-Y, Goldberg VM, et al: Soft-tissue aging and musculoskeletal function. J Bone Joint Surg 75A:1533-1548, 1993.
13. Carter DR: Mechanical loading history and skeletal biology. J Biomech 20:1095-1109, 1987.
14. Carter DR, Blenman PR, Beaupre GS: Correlations between mechanical stress history and tissue differentiation in initial fracture healing. J Orthop Res 6:736-748, 1988.
15. Chao EYS, Aro H: The effect of rigidity on fracture healing in external fixation. Clin Orthop 241:24-35, 1989.
16. Chow R, Harrison JE, Notarius C: Effect of two randomized exercise programmes on bone mass of healthy postmenopausal women. Br Med J 292:607-610, 1987.
17. Claes L, Augat P, Wilke HJ, et al: The influence of interfragmentary movement on bone healing. The 4th Conference of the International Society for Fracture Repair. September 27-October 1. Kobe, Japan, 1994.
18. Claes LE, Heigle CA: The influence of local tissue strain on tissue differentiation and callus formation in secondary fracture healing. Fifth Biennial Meeting of the International Society for Fracture Repair. September 18-21. Ottawa, Canada 6, 1996.
19. Claes L, Wilke JH, Kemper F: Interfragmentary strain and bone healing: An experimental study. Proceedings of International Society for Fracture Repair. August 31-September 2. Helsinki, Finland, and Stockholm, Sweden 64-65, 1987.
20. Cook SD, Baffes GC, Wolfe MW, et al: The effect of recombinant human osteogenic protein-1 on healing of large segmental bone defects. J Bone Joint Surg 76A:827-838, 1994.
21. Cowin SC: Bone stress adaptation models. J Biomech Eng 115:528-533, 1993.
22. Cruess RN, Dumong J: Fracture healing. Can J Surg 18:403-413, 1975.
23. Cunningham NS, Paralkar V, Reddi AH: Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor β1 mRNA expression. Proc Natl Acad Sci 89:11740-11744, 1992.
24. Delloye C, Delefortrie G, Coutellier L, Vincent A: Bone regenerate formation in cortical bone during distraction lengthening: An experimental study. Clin Orthop 250:34-42, 1990.
25. DiGioia AM, Cheal EJ, Hayes WC, Perren SM: Biomechanics of bone resorption, callus formation, and medullary pressurization in healing plated fractures. Trans Orthop Res Soc 12:100, 1987.
26. Eickhoff JA, Molczyk L, Gallagher JC, De Jong S: Influence of isotonic, isometric, and isokinetic muscle strength on bone mineral density of the spine and femur in young women. Bone Miner 20:201-209, 1993.
27. Elias JJ, Li G, Inoue N, Chao EYS: Influence of defect dimensions on long bone structural strength. Trans Orthop Res Soc 22:820, 1997.
28. 2 on calcium homeostasis in postmenopausal women. J Bone Miner Res 9:607-614, 1994.
29. Goodship AE, Kenwright J: The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg 676:650-655, 1985.
30. Hart RT: A theoretical study of the influence of bone maturation rate on surface remodeling prediction: Idealized models. J Biomech 23:241-253, 1990.
31. Hart RT, Davy DT, Heiple KG: A computational method for stress analysis of adaptive elastic material with a view toward applications in strain-induced bone remodeling. J Biomech Eng 106:342-350, 1984.
32. Huiskes R, Hollister SJ: From structure to process, from organ to cell: Recent development of FE-analysis in orthopaedic biomechanics. J Biomech Eng 115:520-527, 1993.
33. Ilizarov GA: The tension stress effect on the genesis and growth of tissue: Part II. The influence of the rate and frequency of distraction. Clin Orthop 239:263-285, 1989.
34. Jingushi S, Joyce ME, Bolander, ME: Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair. J Bone Miner Res 7:1045-1055, 1992.
35. Kassis B, Glorion CH, Tabib W, et al: Callus response to micromovement after elongation in the rabbit. J Pediatr Orthop 16:480-483, 1996.
36. Khouri RK, Koudsi B, Reddi AH: Tissue transformation into bone in vivo: A potential practical application. JAMA 266:1953-1955, 1991.
37. Kuiper JH, Richardson JB, Ashton BA: Strains, hydrostatic pressures, and fluid shear stresses in early fracture callus. Fifth Biennial Meeting of the International Society for Fracture Repair. September 18-21. Ottawa, Canada, 38, 1996.
38. Lanyon LE: Using functional loading to influence bone mass and architecture. Bone 18:37S-43S, 1996.
39. Majeska RJ, Ryaby JT, Einhorn TA: Direct modulation of osteoblastic activity with estrogen. J Bone Joint Surg 76A:713-721, 1994.
40. Markel MD, Wikenheiser MA, Chao EYS: A study of fracture callus material properties: Relationship to the torsional strength of bone. J Orthop Res 8:843-850, 1990.
41. Marsh JL, Nepola JV, Meffert RH: Dynamic external fixation for stabilization of nonunions. Clin Orthop 278:200-206, 1992.
42. Meadows TH, Bronk JT, Chao EYS, Kelly PJ: Effect of weight-bearing on healing of cortical defects in the canine tibia. J Bone Joint Surg 72A:1074-1080, 1990.
43. Menkes A, Mazel S, Redmond RA, et al: Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol 74:2478-2484, 1993.
44. O'Sullivan ME, Chao EYS, Kelly PJ: Current concepts review: The effects of fixation on fracture healing. J Bone Joint Surg 71 A:306-310, 1989.
45. Paley D, Kovelman HF, Herzenberg JE: Ilizarov Technology. In Stauffer RN (ed). Advances in Operative Orthopaedics. Vol 1. St Louis, Mosby-Yearbook 243-278, 1993.
46. Perren SM: Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop 138:175-196, 1979.
47. Rand JA, An KN, Chao EYS, Kelly PJ: A comparison of the effect of open intramedullary nailing and compression-plate fixation on fracture site blood flow and future union. J Bone Joint Surg 63A:427-442, 1981.
48. Rubin CT, Lanyon LE: Regulation of bone formation by applied dynamic loads. J Bone Joint Surg 66A:397, 1984.
49. Rubin CT, Lanyon LE: Osteoregulatory nature of mechanical stimuli: Function as a determinant for adaptive bone remodeling. J Orthop Res 5:300-310, 1987.
50. Sarmiento A, Sobol PA, Hoy AL, et al: Prefabricated functional braces for the treatment of fractures of the tibial diaphysis. J Bone Joint Surg 66A:1328-1339, 1984.
51. Schenk OK: Cytodynamics and Histodynamics of Primary Bone Repair. In Lane JM (ed). Fracture Repair. New York, Churchill Livingstone 23-32, 1987.
52. Stevenson S, Cunningham NS, Davy D, Reddi AH: The effect of osteogenin (a bone morphogenetic protein) on the formation of bone in orthotopic segmentai defects in rats. J Bone Joint Surg 76A:1676-1687, 1994.
53. Sun Y-Q, McLeod KJ, Rubin CT: Mechanically induced periosteal bone formation is paralleled by the up regulation of collagen type one mRNA in osteocytes as measured by in situ reverse transcript-polymerase chain reaction. Calcif Tissue Int 57:456-462, 1995.
54. Windhager R, Tsuboyama T, Siegl H, et al: Effect of bone cylinder length on distraction osteogenesis in the rabbit tibia, J Orthop Res 13:620-628, 1995.
55. Wolf Jr JW, White III AA, Panjabi MM, Southwick WO: Comparison of cyclic loading versus constant compression in the treatment of long-bone fracture in rabbits. J Bone Joint Surg 63A:806-810, 1981.
56. Wolff J: The Law of Bone Remodeling. Berlin, Springer, 1986.
57. Wu JJ, Shyr HS, Chao EYS, Kelly, PJ: Comparison of osteotomy healing under external fixation devices with different stiffness characteristics. J Bone Joint Surg 66A:1258-1264, 1984.
58. Yasko AW, Lane JM, Fellinger EJ, et al: The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). J Bone Joint Surg 74A:659-670, 1992.
59. Yasui N, Kojimoto H, Sasaki K, et al: Factors affecting callus distraction in limb lengthening. Clin Orthop 293:55-60, 1993.