Reductive amination using polyethylene glycol acetaldehyde hydrate generated in situ: Applications to chitosan and lysozyme

Journal of Pharmaceutical Sciences

Volumn 87, Issue 11, 1998, Pages 1446-1449

  Bentley, Michael D ^a   Roberts, Michael J ^a   Milton Harris, J ^a  

^a Shearwater Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL; ACETALDEHYDE; CHITOSAN; LYSOZYME; MACROGOL; MACROGOL DERIVATIVE; SODIUM BOROHYDRIDE;

AMINATION; CONFERENCE PAPER; HYDROGEL; HYDROLYSIS;

EID: 0031762078     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js980064w     Document Type: Article

References (11)

1. Harris, J. M., Ed. Biomédical and Biotechnical Applications of Polyethylene Glycol Chemistry; Plenum: New York, 1992.
2. Harris, J. M., Zalipsky, S., Eds. Polyethylene glycol) Chemistry and Biological Applications; American Chemical Society: Washington, DC, 1997.
3. Zalipsky, S. Chemistry of Polyethylene Glycol Conjugates with Biologically Active Molecules, Adv. Drug Deliv. Rev. 1995, 16, 157-182.
4. Ouchi, T.; Kuroda, H.; Ohya, Y. Design of Antitumor AgentTerminated Polytethylene glycol) Conjugate as Macromolecular Prodrug, Polym. Prepr. 1997, 38, 582-583.
5. Nilsson, K.; Mosbach, K. Immobilization of Ligands with Organic Sulfonyl Chlorides. Methods Enzymol. 1984, 104, 56-59.
6. Gais, H.-J.; Rupert, S, Modification and Immobilization of Proteins with Polyethylene GlycolTresylates, and Polysaccharide Tresylates: evidence Suggesting a Revision of the Coupling Mechanism and the structure of the PolymerPolymer Linkage, Tetrahedron Lett. 1995, 36, 3837-3838.
7. Harris, J. M.; Sedaghat-Herati, M. R. Preparation and use of Polyethylene Glycol Propionaldehyde, Patent U.S. 5,252,714, 1993.
8. Zalipsky, S. Functionalized Poly(ethylene glycol) for Preparation of Biologically Relevant Conjugates Bioconjugate Chem. 1995, 6, 150-165.
9. Lowry, T. H.; Richardson, K. S. Mechanism and Theory in Organic Chemistry, 2nd. ed.; Harper and Row: New York, 1981; pp 637-638.
10. Saito, H.; Wu, X.; Harris, J. M.; Hoffmann, A. S. Graft Copolymers of Poly (ethylene glycol) (PEG) and Chitosan. Macromol. Rapid Commun. 1997, 18, 547-550.
11. Harris, J. M.; Struck, E. C.; Case, M. G.; Paley, S.; Yalpani, M.; Van Alstine, J. M.; Brooks, D. E. Synthesis and Characterization of Poly (ethylene glycol) Derivatives. J. Polym. Sei. 1984, 22, 341-352.