Antibody-mediated thrombosis: Relation to the antiphospholipid syndrome

Lupus

Volumn 7, Issue SUPPL. 2, 1998, Pages

  Vermylen, J ^a   Van Geet, C ^a   Arnout, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Heparin induced thrombocytopenia; OKT3 antibody; Protein S antibody; Von Willebrand factor antibody; Xenograft rejection

Indexed keywords

ANTIBODY; AUTOANTIBODY; FC RECEPTOR; HEPARIN; HERPES ZOSTER IMMUNOGLOBULIN; OKT 3; PROCOAGULANT; PROTEIN S; VON WILLEBRAND FACTOR;

ANTIPHOSPHOLIPID SYNDROME; CELL INTERACTION; CLINICAL FEATURE; COMPLEMENT ACTIVATION; CONFERENCE PAPER; GRAFT REJECTION; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; THROMBOCYTOPENIA; THROMBOSIS; XENOGRAFT;

EID: 0031761887     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/096120339800700215     Document Type: Conference Paper

References (25)

1. Vermylen J, Hoylaerts MF, Arnout J. Antibody-mediated thrombosis Thromb Haemost 1997, 78: 420-423.
2. Pierangeli SS et al. Induction of thrombosis in a mouse model by IgG IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome Thromb Haemost 1995; 74: 1361-1367.
3. Bakimer R, Shoenfeld Y. Pathogenesis of the antiphospholipid syndrome. In: RA Asherson, R Cervera, JC Piette, Y Shoenfeld (eds) The Antiphospholipid Syndrome. CRC Press: Boca Raton, FL, 1996; pp. 59-70.
4. Warkentin TE, Chong BH, Gremacher A. Heparin-induced thrombocytopenia; towards consensus. Thromb Haemost 1998, 79: 1-7.
5. Arnout J. The pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin-induced thrombocytopenia Thromb Haemost 1996; 75. 536-541
6. Amiral J et al. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia Thromb Haemost 1992, 68: 95-96.
7. Chong BH, Castaldi PA, Berndt MC Heparin-induced thrombocytopenia: effects of rabbit IgG, and its Fab and Fc fragments on antibody-heparin-platelet interaction. Thromb Res 1989, 55: 291-295.
8. Warkentin TE et al. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood 1994, 84: 3691-3699.
9. Brondt JT. Platelet aggregation in heparin-induced thrombocytopenia is dependent on complement activation. Blood 1996, 88 517a.
10. Visentin GP, Ford SE, Scott JP, Aster RH. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994; 93: 81-88.
11. Ikeda K et al. C5a induces tissue factor activity on endothelial cells. Thromb Haemost 1997; 77: 394-398.
12. Hoylaerts MF, Thys C, Arnout J, Vermylen J. Recurrent arterial thrombosis linked to auto-immune antibodies enhancing von Wille-brand factor binding to platelets and inducing FcyRII receptor-mediated platelet activation Blood 1998, 91: 2810-2817.
13. Abramowicz D et al. Induction of thromboses within renal grafts by high-dose prophylactic OKT3. Lancet 1992; 339: 777-778.
14. Pradier O et al. Monocyte procoagulant activity induced by in vivo administration of the OKT3 monoclonal antibody. Blood 1996; 87: 3768-3774.
15. Pradier O et al CD40 engagement induces monocyte procoagulant activity through an interleukin-10 dependent pathway. Eur J Immunol 1996; 26: 3048-3054
16. Pradier O et al Procoagulant effect of the OKT3 monoclonal anti-body; involvement of tumor necrosis factor. Kidney Int 1992; 42: 1124-1129.
17. Parker WR, Bruno D, Holzknecht ZE, Platt JL. Characterization and affinity isolation of xenoreactive natural antibodies. J Immunol 1994; 153: 3791-3803
18. Galili U Identification of the natural anti-Gal antibody with α-galactosyl epitopes. a major obstacle for xenotransplantation in humans. Immunol Today 1993, 4: 480-482.
19. Saadi S, Platt JL. Transient perturbation of endothelial integrity induced by antibodies and complement. J Exp Med 1995; 181 : 21-31.
20. O'Regan S, Robitaille P, Pinto-Blonde M, Chartrand C. Delayed rejection of cardiac xenografts in C6-deficient rabbits. Immunology 1979; 38: 245-248.
21. Rosengard AM et al. Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs. A potential approach for preventing xenograft rejection. Transplantation 1995; 59: 1325-1333.
22. Blakely ML et al. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 1994; 58: 1059-1066.
23. Marlar RA, Neumann A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies Semin Thromb Haemostas 1990; 16: 299-309.
24. Levin M et al Postinfectious purpura fulminans caused by an auto-antibody directed against protein S. J Pediatr 1995, 127: 355-363.
25. Lin Y Pathogenisis and prevention of xenotransplant rejection. PhD thesis, University of Leuven, 1998.