Diosmectite for ulcerative colitis. A pilot trial

Clinical Drug Investigation

Volumn 16, Issue 5, 1998, Pages 411-412

  Guslandi, M ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIARRHEAL AGENT; DIOSMECTITE; MESALAZINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLON MUCOSA; DISEASE ACTIVITY; DRUG EFFICACY; FEMALE; HUMAN; MALE; MUCUS; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SYMPTOM; ULCERATIVE COLITIS;

EID: 0031761436     PISSN: 11732563     EISSN: None     Source Type: Journal    
DOI: 10.2165/00044011-199816050-00010     Document Type: Article

References (13)

1. Allen A, Hoskins LC. In: Kirsner JB, Shorter RG, editors. Diseases of the colon and rectum. Baltimore: Williams & Wilkins, 1988: 65-92
2. Hutton DA, Pearson JP, Allen A, et al. Mucolysis of the colonic mucus barrier by faecal proteinases: inhibition by interacting polyacrylate. Clin Sci 1990; 78: 265-71
3. Corfield AP, Williams AJK, Clamp J, et al. Degradation by bacterial enzymes of colonic mucus from normal subjects and patients with IBD: role of sialic acid metabolism and the detection of a novel O-acetyl sialic acid esterase. Clin Sci 1988; 74: 71-8
4. Samson HJ, Allen A, Pearson JP, et al. Faecal proteinase activity: raised values in patients with ulcerative colitis. Gut 1991; 32 (10): 1235-6
5. Pullan RD, Rhodes M, Allen A, et al. Adherent layer of colonic mucus in mucosal protection and IBD. Br J Surg 1992; 79 (11): 1229
6. Allen A, Leonard A. Mucus structure. Gastroenterol Clin Biol 1985; 9: 9-12
7. Mahraoui L, Heyman M, Plique O, et al. Apical effect of diosmectite on damage to the intestinal barrier induced by basal tumour necrosis factor-alfa. Gut 1997; 40: 339-43
8. Madkour AA, Madina EMH, El-Azouni OEZ, et al. Smectite in acute diarrhoea of children: a double-blind placebo controlled clinical trial. J Pediatr Gastroenterol Nutr 1993; 17: 176-81
9. Leber W. A new suspension form of smectite for the treatment of acute diarrhea: a randomized comparative study. Pharmacoterapeutica 1988; 5: 256-60
10. Rachmilewitz D. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. BMJ 1989; 298: 82-6
11. Rhodes J, Thomas G. Nicotine treatment in ulcerative colitis: current status. Drugs 1995; 49: 157-60
12. Finnie IA, Campbell BJ, Taylor BA, et al. Stimulation of colonic mucin synthesis by corticosteroids and nicotine. Clin Sci 1996; 91: 359-64
13. Ilnyckyj A, Shanahan F, Anton PA, et al. Quantification of the placebo response in ulcerative colitis. Gastroenterology 1997; 112: 1854-8