Driving, drug research and the pharmaceutical industry

Human Psychopharmacology

Volumn 13, Issue SUPPL. 2, 1998, Pages

  Patat, A ^a  

^a Biotrial   (France)

Author keywords

Behavioural toxicity; Driving performance; Drug development; Drugs; Impairment

Indexed keywords

ALCOHOL; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ANXIOLYTIC AGENT; HYPNOTIC AGENT;

ARTICLE; ATTENTION; COGNITION; DRIVING ABILITY; DRUG INDUSTRY; DRUG RESEARCH; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SACCADIC EYE MOVEMENT; SPECTROSCOPY;

EID: 0031761003     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1077(1998110)13:2+3.0.CO;2-H     Document Type: Article

References (39)

1. Bittencourt, P. R. M. and Tedeschi, G. (1990). The oculomotor system: multiple pharmacodynamic models. In Human Psychopharmacology: Methods and Measures, Vol. 3, Hindmarch, I. and Stonier, P., (Eds), Wiley, Chichester, pp. 39-60.
2. Broadbent, D. E. (1984). Performance and its measurment. British Journal of Clinical Pharmacology, 18, 5S-9S.
3. Brookhuis, K. A., Volkerts, E. R. and O'Hanlon, J. F. (1987). The effects of some anxiolytics on car-following performance in real traffic. In Alcohol, Drugs and Traffic Safety-T86, Noordzij, P. C. and Roszbach, R. (Eds), Elsevier, Amsterdam, pp. 223-226.
4. Brookhuis, K. A., Volkerts, E. R. and O'Hanlon, J. F. (1990). Repeated dose effects of lormetazepam and flurazepam upon driving performance. European Journal of Clinical Pharmacology, 39, 83-87.
5. 1-histamine receptor antagonist ebastine in 10, 20 and 30 mg dose of triprolidine 10 mg on car driving performance. British Journal of Clinical Pharmacology, 36, 67-70.
6. Carskadon, M. A., Dement, W. C., Mitler, M. M., Roth, T., Westbrook, P. R. and Keenan, S. (1986). Guidelines for the Multiple Sleep Latency Test (MSLT). Sleep, 9, 519-524.
7. Clayton, A. B. (1976). The effects of psychotropic drugs upon driving-related skills. Human Factors, 18, 241-252.
8. Cohen, A. F., Posner, J., Ashby, L., Smith, R. and Peck A. W. (1984). A comparison of methods for assessing the sedative effects of diphenhydramine on skills related to car driving. European Journal of Clinical Pharmacology, 4, 197-206.
9. Consensus Report (1985). Drug concentrations and driving impairment. Journal of the American Medical Association, 254, 2618-2621.
10. Coupland, N. J., Marshall, R. W., Wilson, S. J. and Nutt, D. J. (1995). The use of saccadic eye movement measures in psychopharmacology. In Human Psychopharmacology: Methods and Measures, Vol. 5, Hindmarch, I. and Stonier, P. (Eds), Wiley, Chichester, pp. 137-155.
11. De Gier, J. J. (1979). A subjective measurement of the influence of ethyl alcohol in moderate levels on real driving performance. Blutalkohol, 16, 363-370.
12. Herrmann, W. M. (1982). Development and critical evaluation of an objective procedure for the electroencephalographic classification of psychotropic drugs. In EEG in Drug Research, Herrmann, W. M. (Ed.), Gustav Fischer, Stuttgart, pp. 249-351.
13. Hindmarch, I. (1980). Psychomotor function and psychoactive drugs. British Journal of Clinical Pharmacology, 10, 189-209.
14. Irving, A. (1988). A proposed investigation into Drug Impairment Testing Methodology. In Medicine and Road Traffic Safety, Burley D. and Silvestone, T. (Wds), CNS (Clinical Neuro Science), London, pp. 99-110.
15. Irving, A. and Jones, W. (1992). Methods for testing impairment of driving due to drugs. European Journal of Clinical Pharmacology, 43, 61-66.
16. Itil, T. M., Menon, G. N. and Itil, K. Z. (1982). Computer EEG drug data base in psychopharmacology and in drug development. Psychopharmacology Bulletin. 18(4), 165-172.
17. Johnson, L. C. and Chernik, D. A. (1982). Sedative hypnotics and human performance. Psychopharmacology, 76, 101-113.
18. Louwerens, J. W., Gloerich, A. B. M., De Vries, G., Brookhuis, K.A. and O'Hanlon, J. F. (1987). The relationship between drivers' blood alcohol concentration (BAC) and actual driving performance during high speed travel. In Alcohol, Drugs and Traffic Safety, Noordzij, P. C. and Roszbach, R. (Eds), Exerpta Medica, Amsterdam, pp. 183-186.
19. Moskowitz, H. (1984). Attention tasks as skills performance measures of drug effects. British Journal of Clinical Pharmacology, 18, 51S-61S.
20. O'Hanlon, J. F. (1981). Psychotropic medication and driving safety: a critical review. In Human Factors in Transportation Research, Oborne, D. J. and Lewis, J. A. (Eds), Academic Press, London.
21. O'Hanlon, J. F. (1984). Driving performance under the influence of drugs, a rationale for, and application of, a new test. British Journal of Clinical Pharamcology, 18, 121S-129S.
22. O'Hanlon, J. F. and Kelley, G. R. (1977). Comparison of performance and physiological changes between drivers who perform well and poorly during prolonged vehicle operation. In Vigilance: Theory, Operational Performance and Physiological Correlates, Mackie R. R. (Ed.), Plenum Press, New York, pp. 189-201.
23. O'Hanlon, J. F. and Ramaekers, J. G. (1995). Anti-histamine effects on actual driving performance in a standard test: a summary of Dutch experience 1989-1994. Allergy, 50, 234-242.
24. O'Hanlon, J. F., Brookhuis, K. A., Louwerens, J. W. and Volkerts, E. R. (1986). Performance testing as part of new drug registration. In Drugs and Driving, O'Hanlon J. F. and De Gier, J.J. (Eds), Taylor and Francis, London, pp. 311-327.
25. O'Hanlon, J. F., Vermeeren, A., Uiterwijk, M. M. C., Van Veggel, L. M. A. and Swijgman, H. F. (1995). Anxiolytics' effects on the actual driving performance of patients and healthy volunteers in a standardised test. Neuropsychobiology, 31, 81-88.
26. O'Hanlon, J. F., Robbe, H. W. J., Vermeeren, A., Van Leeuwen, C. J. and Danjou, P. E. (1998). Venlafaxine's effects on healthy volunteers' driving, psychomotor and vigilance performance during 15-day fixed and incremental dosing regimens. Journal of Clinical Pharmacology, 18(3), 212-221.
27. Patat, A., Trocherie, S., Thebault, J. J., Rosenzweig, P., Dubruc, C., Bianchetti, G., Court, L. A. and Morselli, P. L. (1994). EEG profile of intravenous zolpidem in healthy volunteers. Psychopharmacology, 114, 138-146.
28. Ramaekers, J. G., Uiterwijk, M. and O'Hanlon, J. F. (1992). Effects of loratadine and cetirizine on actual driving and psychometric test performance and EEG during driving. European Journal of Clinical Pharmacology, 42, 363-369.
29. Ramaekers, J. G., Van Veggel, L. M. A. and O'Hanlon, J. F. (1994). A cross-study comparison of moclobemide and brofaromine on actual driving performance and estimated sleep. Clinical Neuropharmacology, (Suppl.), 9-18.
30. Ramaekers, J. G., Muntjewerff, N. D. and O'Hanlon, J. F. (1995). A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance. British Journal of Clinical Pharmacology, 39, 397-404.
31. Ray, W. A., Fought, R. L. and Decker, M. D. (1992). Psychoactive drugs and the risk on injurious motor vehicle crashes in elderly drivers. American Journal of Epidemiology, 136, 873-883.
32. Saletu, B. (1987). The use of EEG in drug profiling. In Human Psychopharmacology: Measures and Methods, Vol. 1, Hindmarch, I. and Stonier, P. D. (Eds), Wiley, Chichester, pp. 173-200.
33. Starmer, G. A. (1990). Alcohol and car driving: impairment and per se limits for drivers. In Human Psychopharmacology: Methods and Measures, Vol. 3, Hindmarch, L and Stonier, P. (Eds), Wiley, Chichester, pp. 165-194.
34. Van Laar, M. W., Volkerts, E. R. and Van Willigenburg, A. P. P. (1992). Therapeutic effects and effects on actual driving performance of chronically administered buspirone and diazepam in anxious outpatients. Journal of Clinical Psychopharmacology, 12, 86-95.
35. Van Laar, M. W., Volkerts, E. R. and van Willigenburg, A. P. P. (1995). Acute and subchronic effects of nefazodone and imipramine on highway driving, cognitive functions, and daytime sleepiness in healthy adult and elderly subjects. Journal of Clinical Psychopharmacology, 15, 30-40.
36. Vuurman, E., Uiterwijk, M., Rosenzweig, P. and O'Hanlon, J. F (1994). Effects of inizolastine and clemastine in actual driving and psychomotor performance in healthy volunteers. European Journal of Clinical Pharmacology, 47, 253-259.
37. Willumeit, H. P., Ott, H., and Kuschel, C. (1991). Effects of lormetazepam and other benzodiazepines receptor ligands on car driving related skills. Human Psychopharmacology, 6, 209-218.
38. Willumeit, H. P., Ott, H. and Kuschel, C. (1993). Driving performance models: comparison of a tracking simulator and an over-the-road test in relation to drug intake. In Human Psychopharmacology: Methods and Measures, Vol. 4, Hindmarch, I. and Stonier, P. D. (Eds), Wiley, Chichester. pp. 15-35.
39. Wittenborn, J. R. (1979). The effects of benzodiazepines on psychomotor performance. British Journal of Clinical Pharmacology, 7, 61S-67S.