An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC β-lactamase expression

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 12, 1998, Pages 3296-3300

  Langaee, Taimour Yousef ^a   Dargis, Michèle ^a   Huletsky, Ann ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE;

ARTICLE; BACTERIAL GENE; GENE EXPRESSION REGULATION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA;

EID: 0031760856     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.12.3296     Document Type: Article

References (32)

1. Ambler, R. P. 1980. The structure of β-lactamases. Philos. Trans. R. Soc. London Ser. B. 289:321-331.
2. Bennett, P. M., and I. Chopra. 1993. Molecular basis of β-lactamase induction in bacteria. Antimicrob. Agents Chemother. 37:153-158.
3. Bush, K., G. A. Jacoby, and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39:1211-1233.
4. Campbell, J. I. A., O. Ciofu, and N. Høiby. 1997. Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different β-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region. Antimicrob. Agents Chemother. 41:1380-1384.
5. Dietz, H., D. Pfeifle, and B. Wiedemann. 1997. The signal molecule for β-lactamase induction in Enterobacter cloacae is the anhydromuramyl-pentapeptide. Antimicrob. Agents Chemother. 41:2113-2120.
6. Ehrhardt, A. F., C. C. Sanders, J. R. Romero, and J. S. Leser. 1996. Sequencing and analysis of four new Enterobacter ampD alleles. Antimicrob. Agents Chemother. 40:1953-1956.
7. Fleischmann, R. D., M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, et al. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496-512.
8. Gold, L. 1988. Posttranscriptional regulatory mechanisms in Escherichia coli. Annu. Rev. Biochem. 57:199-233.
9. Höltje, J.-V., U. Kopp, A. Ursinus, and B. Wiedemann. 1994. The negative regulator of β-lactamase induction AmpD is a N-acetyl-anhydromuramyl-L-alanine amidase. FEMS Microbiol. Lett. 122:159-164.
10. Honoré, N., M. H. Nicolas, and S. T. Cole. 1989. Regulation of enterobacterial cephalosporinase production: the role of a membrane-bound sensory transducer. Mol. Microbiol. 3:1121-1130.
11. Jacobs, C., L. J. Huang, E. Bartowsky, S. Normark, and J. T. Park. 1994. Bacterial cell wall recycling provides cytosolic muropeptides as effectors for β-lactamase induction. EMBO J. 13:4684-4694.
12. Jacobs, C., B. Joris, M. Jamin, K. Klarsov, J. Van Beeumen, D. Mengin-Lecreulx, J. van Heijenoort, J. T. Park, S. Normark, and J.-M. Frère. 1995. AmpD, essential for both β-lactamase regulation and cell wall recycling, is a novel cytosolic N-acetylmuramyl-L-alanine amidase. Mol. Microbiol. 15:553-559.
13. Jacobs, C., J.-M. Frère, and S. Normark. 1997. Cytosolic intermediates for cell wall biosynthesis and degradation control inducible β-lactam resistance in gram-negative bacteria. Cell 88:823-832.
14. Kopp, U., B. Wiedemann, S. Lindquist, and S. Normark. 1993. Sequences of wild-type and mutant ampD genes of Citrobacter freundii and Enterobacter cloacae. Antimicrob. Agents Chemother. 37:224-228.
15. Korfmann, G., and C. C. Sanders. 1989. ampG is essential for high-level expression of AmpC β-lactamase in Enterobacter cloacae. Antimicrob. Agents Chemother. 33:1946-1951.
16. Langaee, T. Y., and A. Huletsky. 1996. Characterization of the ampD gene encoding a regulator of cephalosporinase expression in Pseudomonas aeruginosa PAO1 abstr. A-37, p. 139. In Abstracts of the 96th General Meeting of the American Society for Microbiology 1996. American Society for Microbiology, Washington, D.C.
17. Langaee, T. Y., and A. Huletsky. 1997. Identification of the ampG gene encoding a signal transducer for induction of the chromosomal AmpC β-lactamase in Pseudomonas aeruginosa PAO1, abstr. A-3, p. 1. In Abstracts of the 97th General Meeting of the American Society for Microbiology 1997. American Society for Microbiology, Washington, D.C.
18. Langley, D., and J. R. Guest. 1977. Biochemical genetics of the alpha-keto acid dehydrogenase complexes of Escherichia coli K12: isolation and biochemical properties of deletion mutants. J. Gen. Microbiol. 99:263-276.
19. Lindquist, S., M. Galleni, F. Lindberg, and S. Normark. 1989. Signalling proteins in enterobacterial AmpC β-lactamase regulation. Mol. Microbiol. 3: 1091-1102.
20. Lisser, S., and H. Margalit. 1993. Compilation of E. coli mRNA promoter sequences. Nucleic Acids Res. 21:1507-1516.
21. Lodge, J., S. Busby, and L. Piddock. 1993. Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC promoter. FEMS Microbiol. Lett. 111:315-320.
22. Nakai, K., and M. Kanehisha. 1991. Expert system for predicting protein localization sites in gram-negative bacteria. Proteins 11:95-110.
23. Nicolas, M. H., N. Honore, V. Jarlier, A. Philippon, and S. T. Cole. 1987. Molecular genetic analysis of cephalosporinase production and its role in β-lactam resistance in clinical isolates of Enterobacter cloacae. Antimicrob. Agents Chemother. 31:295-299.
24. Normark, S., E. Bartowsky, J. Erickson, C. Jacobs, F. Lindberg, S. Lindquist, K. Weston-Hafer, and M. Wikström. 1994. Mechanisms of chromosomal β-lactamase induction in Gram-negative bacteria, p. 485-503. In J.-M. Ghuysen and R. Hakenbeck (ed.), Bacterial cell wall. Elsevier Science B.V., Amsterdam, The Netherlands.
25. Normark, S. 1995. β-Lactamase induction in Gram-negative bacteria is intimately linked to peptidoglycan recycling. Microb. Drug Resist. 1:111-114.
26. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed., p. 1.21-1.101. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Sanders, C. C., and W. E. Sanders, Jr. 1992. β-Lactam resistance in gram-negative bacteria: global trends and clinical impact. Clin. Infect. Dis. 15:825-839.
28. Spratt, B. G., P. J. Hedge, S. Teheesen, A. Edelman, and J. K. Broome-Smith. 1986. Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9. Gene 41:337-342.
29. Stapleton, P., K. Shannon, and I. Phillips. 1995. DNA sequence differences of ampD mutants of Citrobacter freundii. Antimicrob. Agents Chemother. 39: 2494-2498.
30. Starnbach, M. N., S. Falkow, and L. S. Tompkins. 1989. Species-specific detection of Legionella pneumophila in water by DNA amplification and hybridization. J. Clin. Microbiol. 27:1257-1261.
31. Trépanier, S., A. Prince, and A. Huletsky. 1997. Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob. Agents Chemother. 41:2399-2405.
32. West, S. E. H., and B. H. Iglewski. 1988. Codon usage in Pseudomonas aeruginosa. Nucleic Acids Res. 6:9323-9335.