Is the measurement of placental protein-14 and CA-125 in plasma and uterine flushings useful in the evaluation of peri-menopausal and post-menopausal bleeding?

Human Reproduction

Volumn 13, Issue 10, 1998, Pages 2895-2901

  Li, T C ^a   Okon, M A ^a   Dalton, C F ^a   Heatley, M ^b   Laird, S M ^a,c  

^a JESSOP HOSPITAL FOR WOMEN   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^c SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

Author keywords

CA 125; Endometrial proteins; Peri menopausal bleeding; PP14

Indexed keywords

CA 125 ANTIGEN; PLACENTA PROTEIN 14;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENDOMETRIUM BIOPSY; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MENOPAUSE; POSTMENOPAUSE; PROSPECTIVE STUDY; UTERUS BLEEDING;

EID: 0031760554     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.10.2895     Document Type: Article

References (31)

1. Abrao, M.S., Pbdgaec, S.,Filho, B.M. et al. (1997) the use of biochemical markers in the diagnosis of pelvic endometriosis. Hum. Reprod., 12, 2523-2527.
2. Anonymous (1989). Announcements FIGO stages - 1988 revision. Gynecol. Oncol., 35, 125-126.
3. Batool, T., Reginald, P.W. and Hughes, J.H. (1994) Outpatient pipelle endometrial biopsy in the investigation of post-menopausal bleeding. Br. J. Obstet. Gynaecol., 101, 545-546.
4. Bolton, A.E., Chapman, M.G., Stoker, R.J. et al. (1983). The radioimmunoassay of human placental protein 14 (PP14). Clin. Chem. Acta, 135, 283-288.
5. Byrjalsen, I., Thormann, L., Meinecke, B. et al. (1992), Serum placental protein 14 (PP14) reflects endometrial status during hormone replacement therapy. Hum. Reprod., 7, 1042-1047.
6. Chatzaki, E., Gallagher, C. J., Iles, R.K. et al. (1994). Characterisation of the differential expression of marker antigens by normal and malignant endometrium epithelium. Br. J. Cancer, 69, 1010-1014.
7. Dalton, C.F., Laird, S.M., Serie, E. et al. (1995) The measurement of CA-125 and placental protein 14 in uterine flushings in women with recurrent miscarriage: relation to endometrial morphology. Hum. Reprod., 10, 2680-2684.
8. Eddows, H.A. (1990) A more acceptable technique for out-patient endometrial biopsy. Br. J. Obstet. Gynaecol., 97, 961-962.
9. Fothergill, D.J. and Brown V.A. (1992). Histological sampling of the endometrium a comparison between formal curettage and pipelle sampler. Br. J. Gynaecol., 99, 779-780.
10. Ho, H.N., Wu, M.Y., Chen, S.U. et al. (1997) Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis. Hum. Reprod., 12, 2810-2815.
11. Jacobs, I.J. and Bast, R. (1989). The CA-125 tumour associated antigen; a review of the literature. Hum. Reprod., 4, 1-12.
12. Jacobs, I.J., Rivera, H., Oram, D.H. and Bast, R.C. (1993). Differential diagnosis of ovarian cancer with tumour markers CA-125 CA 15-3 and TAG 72.3. Br. J. Obstet. Gynaecol., 100, 1120-1124.
13. Julkunen, M., Koistinen, R. and Sjoberg, J. (1986). Secretory endometrium synthesises placental protein 14. Endocrinology, 118, 1782-1786.
14. Kitchener, H.C. (1995). The post-menopausal bleeding clinic. Year Book of the Royal College of Obstetricians and Gynaecologists, 173-179.
15. Laird, S.M., Tuckerman, EM., Saravelos, H. and Li, T.C. (1996). The production of tumour necrosis factor α (TNF-α) by human endometrial cells in culture. Hum. Reprod., 11, 1318-1323.
16. Li, T.C., Dalton, C.F., Hunjan, K. et al. (1993a). The correlation of placental protein 14 concentrations in uterine flushings and endometrial morphology in the peri-implantation period. Hum. Reprod., 11, 1923-1927.
17. Li, T.C., Ling, E., Dalton, C. et al. (1993b). Concentration of endometrial protein PP14 in uterine flushings throughout the menstrual cycle in normal fertile women. Br. J. Obstet. Gynaecol. 100, 460-464.
18. Longrave, T.A., Kempson, R.L. and Hendrackson, M.R. (1995) Endometrial hyperplasia, metaplasia and carcinoma. In Fox, H., Wells, M. (eds), Haines and Taylor Obstetrical and Gynaecological Pathology. Churchill Livingstone, New York, pp. 449.
19. McKenna, A., Li, T.C., Dalton, C. et al. (1993). Placental protein 14 levels in uterine flushings and plasma of women with unexplained infertility. Feriil. Steril., 59, 577-582.
20. Morrow, D.M., Xiong, N., Getty, R.R. et al. (1994). Hematopoietic placental protein 14. An immunosuppressive factor in cells of the megakaryocytic lineage. Am. J. Pathol., 145, 1485-1495.
21. Rose, P.O., Sommers, R.M., Reale, F.R. et al. (1994). Serial serum CA-125 measurements for evaluation of recurrence in patients with endometrial carcinoma. Obstet. Gynecol. 84, 12-16.
22. Rustin, G.J., van-der-Burg, M.E. and Berek, J.S. (1993), Advanced ovarian cancer. Tumour markers. Ann. Oncol., 4 (suppl. 4), 71-77.
23. Scambia, G., Gadducci, A., Panici, PB. et al. (1994). Combined use of CA-125 and CA 15-3 in patients with endometrial carcinoma. Gynecol. Oncol., 54, 292-297.
24. Seleem, A., Hills, F.A., Salem, H.T. et al. (1996) Mechanism of action of the intrautenne contraceptive device: evidence for a specific biochemical deficiency in the endometrium. Hum. Reprod., 11, 1200-1222.
25. Stovall, T. C., Ling, F.W. and Morgan, P.L. (1991). A prospective randomised comparison of the pipelle en dometrial sampling device with the novak curette. Am. J. Obstet. Gynecol, 165, 1287-1289,
26. Tabibzadeh, S., Kong, Q.F. and Sun, X.Z. (1993) Regulatory roles of TNF-α on trunsepithelial migration of leukocytes and epithelial dyscohesion. J. Endocrinol, 44, 417-425.
27. Tabibzadeh, S., Kong, Q.F., Kapur, S. et al. (1995) Tumour necrosis factor-α-mediated dyscohesion of epithelial cells is associated with discorded expression of cadherin/β-catenin and disassembly of actin filaments. Mol. Hum. Reprod., 1, 994-1004.
28. Takeshima, N., Shimizu, Y., Umezawa, S. et al. (1994). Combined assay of serum levels of CA 125 and CA 19-9 in endometrial carcinoma. Gynecol. Oncol., 54, 321-326.
29. Tulppala, M., Julkunen, M., Tiitinen, A. et al. (1995) Habitual abortion is accompanied by low serum levels of placental protein 14 in the luteal phase of the fertile cycle. Fertil. Steril., 63, 792-795.
30. Wood, PL., Waites, G.T. MacVicar, J. et al. (1988). Immunohistological localization of pregnancy-associated endometrial (α-PEG) in endometrial adenocarcinoma and effect of medroxyprogesterone acetate. Br. J. Obstet. Gynaecol., 95, 1292-1298.
31. Zeimet, A.G., Muller-Holzner, E., Marth, C. et al. (1993). Tumour marker CA-125 in tissues of the female reproductive tract and in serum during the normal menstrual cycle. Fertil. Steril., 59, 1028-1035.