The effect of antiallergic intranasal formulations on ciliary beat frequency of human nasal epithelium in vitro

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 53, Issue 10, 1998, Pages 986-989

  Alberty, J ^a,b   Stoll, W ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Klinik und Poliklinik fur Neurologie   (Germany)

Author keywords

Azelastine; Ciliary beat frequency; Dimethindene maleate; Disodium cromoglycate; Intranasal antiallergic therapy

Indexed keywords

AZELASTINE; BENZALKONIUM CHLORIDE; CROMOGLYCATE DISODIUM; DIMETINDENE;

ALLERGY; ARTICLE; CILIARY MOTILITY; DRUG EFFECT; DRUG FORMULATION; HOST RESISTANCE; HUMAN; HUMAN CELL; NOSE MUCOSA; PRIORITY JOURNAL;

EID: 0031759049     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1998.tb03801.x     Document Type: Article

References (25)

1. Deitmer T. Physiology and pathology of the mucociliary system. Adv Otorhinolaryngol 1989;43:1-143.
2. Sakakura Y. Mucociliary function during experimentally induced rhinovirus infection in man. Ann Otol Rhinol Laryngol 1974;82:203-11.
3. Sakakura Y, Ukai K, Majima Y, Murai S, Harada T, Miyoshi Y. Nasal mucociliary clearance under various conditions. Acta Otolaryngol (Stockh) 1983;96:167-73.
4. Ohashi Y, Nakai Y, Kihara S, Ikeoka H, Takano H, Imoto T. Ciliary activity in patients with nasal allergies. Eur Arch Otorhinolaryngol 1985;242:141-7.
5. Deitmer T, Scheffler R. The effect of different preparations of nasal decongestants on ciliary beat frequency in vitro. Rhinology 1993;31:151-3.
6. van de Donk HJM, van den Heuvel AGM, Zuidema J, Merkus FWHM. The effects of nasal drops and their additives on human nasal mucociliary clearance. Rhinology 1982;20:127-37.
7. Albegger K. Symptomatische Therapie der allergischen Rhinitis. Laryngol Rhinol Otol (Stuttg) 1990;69:613-20.
8. Lund V. Seasonal allergic rhinitis - a review of current therapy. Allergy 1996;51:5-7.
9. Meltzer EO, Storms WW, Pierson WE, et al. Efficacy of azelastinc in perennial allergic rhinitis: clinical and rhinomanometric evaluation. J Allergy Clin Immunol 1988;82: 447-55.
10. Gatspar H, Nolte D, Aurich R, et al. Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis. Allergy 1994;49:152-8.
11. Charpin D, Godard P, Garay RP, Baehre M, Herman D, Michel FB. A multicenter clinical study of the efficacy and tolerability of azelastine nasal spray in the treatment of seasonal allergic rhinitis: a comparison with oral cetrizine. Eur Arch Otorhinolaryngol 1995;252:455-8.
12. Dalhamn T, Rylander R. Frequency of ciliary beat measured with a photosensitive cell. Nature 1962;196:592-3.
13. Riechelmann H, Hafner B, Mann W. Ziliare Aktivität und Sekrettransport bei der allergischen Reaktion der Nasenschleimhaut. Allergologie 1992;15:224-8.
14. Su XY, Po AL. The effect of some commercially available antihistamine and decongestant intranasal formulations on ciliary beat frequency. J Clin Pharm Ther 1993;18:219-22.
15. Tamaoki J, Chiyolani A, Sakai N, Takeyama K, Konno K. Effect of azelastine on sulphur dioxide induced impairment of ciliary motility in airway epithelium. Thorax 1993;48: 542-6.
16. Merkus FW, Schusler van Hees MT. Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance. Allergy 1992;47:230-3.
17. van de Donk HJM, Zuidema J, Merkus FWHM. The influence of the pH and osmotic pressure upon tracheal ciliary beat frequency as determined with a new photoelectric registration device. Rhinology 1980;18:93-104.
18. Ingels KJAO, Kortmann MJW, Nijziel MR, Graamans K, Huizing EH. Factors influencing ciliary beat measurements. Rhinology 1991;29:17-26.
19. Breuninger H. Über das physikalisch-chemische Verhalten des Nasenschleims. Arch Klin Exp Ohren Nasen Kehlkopfheilk 1964;184:133-8.
20. van de Donk HJM, Muller-Plantema IP, Zuidema J, Merkus FWHM. The effects of preservatives on the ciliary beat frequency of chicken embryo tracheas. Rhinology 1980;18: 119-33.
21. van de Donk HJM, Zuidema J, Merkus FWHM. The effects of nasal drops on the ciliary beat frequency of chicken embryo tracheas. Rhinology 1981;19:215-30.
22. Horak F, Jäger S, Nirnberger G, Berger U, Andresen L, Vix JM, Rehn D. Pharmacodynamic dose finding of dimethindene in a sustained release formulation. Arzneimittelforschung 1993;43:1193-5.
23. Horak F, Jäger S, Berger U, et al. Controlled exposure to mite allergen for a dose finding of dimethindene maleale (DMM). Agents Actions 1994;41:C124-6.
24. Ciprandi G, Pronzato C, Passalacqua G, et al. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. J Allergy Clin Immunol 1996;98: 1088-96.
25. Shirasaki H, Asakura K, Sohma S, Kataura A. Inhibitory effects of azelastine on nasal allergic responses in sensitized guinea pigs. Eur Arch Otorhinolaryngol 1992;249: 279-82.