Functional adrenal cortical tumors in childhood: A study of ploidy, p53- protein and nucleolar organizer regions (AgNORs) as prognostic markers

Journal of Pediatric Endocrinology and Metabolism

Volumn 11, Issue 5, 1998, Pages 597-605

  Venara, Marcela ^a,c   Sanchez Marull, Ricardo ^b   Bergada, Ignacio ^a   Gamboni, Mercedes ^b   Chemes, Hector ^a  

^a HOSPITAL DE NIÑOS RICARDO GUTIÉRREZ   (Argentina)

^b Sanatorio Mater Dei   (Argentina)

^c Hospital de Niños   (Argentina)

Author keywords

Adrenal cortical tumors; AgNORs; Flow cytometry; Image analysis; Nucleolar organizers; p53 protein; Pediatrics; Ploidy

Indexed keywords

DNA; PROTEIN P53;

ADOLESCENT; ADRENAL CORTEX TUMOR; ANEUPLOIDY; ARTICLE; CHILD; CHILDHOOD CANCER; CHROMOSOME NOR; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING DISEASE; DIPLOIDY; FEMALE; HUMAN; HUMAN TISSUE; INFANT; MALE; METASTASIS; PROGNOSIS; VIRILIZATION;

EID: 0031758073     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.1998.11.5.597     Document Type: Article

References (23)

1. Hough A, Hollifield J, Page D, Hartmann W. Prognostic factors in adrenal cortical tumors. A mathematical analysis of clinical and morphological data. Am J Clin Pathol 1979; 72: 390-399.
2. van Slooten H, Schaberg A, Smeek D, Moolenaar A. Morphologic characteristics of benign and malignant adrenocortical tumors. Cancer 1985; 55: 766-773.
3. Weiss L. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 1984; 8: 163-169.
4. Bowlby L, Debault L, Abraham S. Flow cytometric analysis of adrenal cortical tumor DNA. Relationship between cellular DNA and histopathologic classification. Cancer 1986; 58: 1499-1505.
5. Hosaka Y, Rainwater L, Grant C, Young W, Farrow G, van Heerden J, Lieber M. Adrenocortical carcinoma: Nuclear deoxyribonucleic acid ploidy studied by flow cytometry. Surgery 1987; 102: 1027-1034.
6. Amberson J, Vaughan D, Gray G, Naus G. Flow cytometric analysis of nuclear DNA from adrenocortical neoplasms. A retrospective study using paraffin-embedded tissue. Cancer 1987; 59:2091-2095.
7. Suzuki T, Sasano H, Nisikawa T, Rhame J, Wilkinson D, Nagura H. Discerning malignancy in human adrenocortical neoplasms: Utility of DNA flow cytometry and immunohistochemistry. Mod Pathol 1992; 5: 224-231.
8. Cagle P, Hough A, Pysher J, Page D, Johnson E, Kirkland R, Holcombe J, Hawkins E. Comparison of adrenal cortical tumors in children and adults. Cancer 1986; 57: 2235-2237.
9. Taylor S, Roederer M, Murphy R. Flow cytometry DNA analysis of adrenocortical tumors in children. Cancer 1987; 59: 2059-2063.
10. Bugg M, Ribeiro R, Roberson P, Lloyd R, Sandrini R, Silva J, Epelman S, Shapiro D, Parham D and the Brazilian Group for Treatment of Childhood Adrenocortical Tumors. Correlation of pathologic features with clinical outcome in pediatric adrenocortical neoplasia. A study of a Brazilian population. Am J Clin Pathol 1994; 101: 625-629.
11. Lin S, Lee Y, Tsai J. Mutations of the p53 gene in human functional adrenal neoplasms. J Clin Endocrinol Metab 1994; 78: 483-491.
12. Reincke M, Karl M, Travis W, Mastorakos G, Allollio B, Marston Linehan H, Chrousos G. p53 mutations in human adrenocortical neoplasms: Immunohistochemical and molecular studies. J Clin Endocrinol Metab 1994; 78: 790-794.
13. Sasano H, Saito Y, Sato I, Sasano N, Nagura H. Nucleolar organizer regions in human adrenocortical disorders. Mod Pathol 1990; 3: 591-595.
14. Bergada I, Venara M, Maglio S, Ciaccio M, Diez B, Bergada C, Chemes H. Functional adrenal cortical tumors in pediatric patients. A clinicopathologic and immunohistochemical study of a long-term follow-up series. Cancer 1996; 77: 771-777.
15. Hedley D, Friedlander M, Taylor I, Rugg C, Musgrove E. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 1983; 31: 1333-1335.
16. Shankey T, Rabinovitch P, Bagwell B, Bauer K, Duque R, Hedley D, Mayall B, Wheeless L. Guidelines for implementation of clinical DNA cytometry. Cytometry 1993; 14: 472-477.
17. Crocker J, Nar P. Nucleolar organizer in lymphomas. J Pathol 1987; 151: 111-118.
18. Kenny F, Hashida Y, Askari A, Sieber W, Fetterman G. Virilizing tumors of the adrenal cortex. Am J Dis Child 1968; 115: 445-448.
19. Hayles A, Hahn H, Sprague R, Bahn R, Priestley J. Hormone-secreting tumors of the adrenal cortex in children. Pediatrics 1966; 37: 19-25.
20. Ribeiro R, Sandrini Neto R, Schell M, Lacerda L, Sambaio G, Cat I. Adrenocortical carcinoma in children: a study of 40 cases. J Clin Oncol 1990; 8: 67-74.
21. Lee P, Winter R, Green O. Virilizing adrenocortical tumors in childhood: eight cases and a review of literature. Pediatrics 1985; 76: 437-444.
22. Lack E, Mulvihill J, Travis W, Kozakewich H. Adrenal cortical neoplasms in the pediatric and adolescent age group. Clinicopathologic study of 30 cases with emphasis on epidemiological and prognosis factors. In: Rosen P, Fechner R, eds. Pathology Annual, Part 1, Vol. 27. Norwalk, CT-San Mateo, CA: Appleton & Lange, 1992; 1-53.
23. Siitonen S, Kallioniemi O, Helin H, Isola J. Prognostic value of cells with more than 5c DNA content in node-negative breast cancer as determined by image cytometry from tissue sections. Hum Pathol 1993; 24: 1348-1353.