A role for guanyl nucleotide-binding regulatory protein β- and γ- subunits in the expression of the adrenocorticotropin receptor

Molecular Endocrinology

Volumn 12, Issue 12, 1998, Pages 1879-1887

  Qiu, Rong ^a   Frigeri, Claudia ^a   Schimmer, Bernard P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CORTICOTROPIN RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0031756169     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.12.0212     Document Type: Article

References (41)

1. Cone RD, Mountjoy KG, Robbins LS, Nadeau JH, Johnson KR, Roselli-Rehfuss L, Mortrud MT 1993 Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann NY Acad Sci 680:364-380
2. Boston BA, Cone RD 1996 Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 137:2043-2050
3. Slominski A, Ermak G, Mihm M 1996 ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Metab 81:2746-2749
4. Cammas FM, Pullinger GD, Barker S, Clark AJL 1997 The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1. Mol Endocrinol 11:867-876
5. Lebrethon M-C, Naville D, Begeot M, Saez JM 1994 Regulation of corticotropin receptor number and messenger RNA in cultured human adrenocortical cells by corticotropin and angiotensin II. J Clin Invest 93:1828-1833
6. Penhoat A, Jaillard C, Saez JM 1994 Regulation of bovine adrenal cell corticotropin receptor mRNA levels by corticotropin (ACTH) and angiotensin-II (A-II). Mol Cell Endocrinol 103:R7-R10
7. Mountjoy KG, Bird IM, Rainey WE, Cone RD 1994 ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines. Mol Cell Endocrinol 99:R17-R20
8. Schimmer BP, Kwan WK, Tsao J, Qiu R 1995 Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor. J Cell Physiol 163:164-171
9. Parker KL, Schimmer BP 1997 Steroidogenic factor 1: a key determinant of endocrine development and function. Endocr Rev 18:361-377
10. Marchal R, Naville D, Durand P, Begeot M, Penhoat A 1998 A steroidogenic factor-1 binding element is essential for basal human ACTH receptor gene transcription. Biochem Biophys Res Commun 247:28-32
11. Schimmer BP, Tsao J, Collie G, Wong M, Schulz P 1985 Analysis of the mutation to forskolin-resistance in Y1 adrenocortical tumor cells. Endocr Res 10:365-386
12. Schimmer BP, Tsao J 1984 Isolation of forskolin-resistant adrenal cells defective in the adenylate cyclase system. J Biol Chem 259:5376-5379
13. Qiu R, Tsao J, Kwan W, Schimmer BP 1996 Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein α-subunits. Mol Endocrinol 10:1708-1718
14. Mitchell J, Northup JK, Schimmer BP 1992 Defective guanyl nucleotide-binding protein βγ subunits in a forskolin-resistant mutant of the Y1 adrenocortical cell line. Proc Natl Acad Sci USA 89:8933-8937
15. Olson MF, Tsao J, Pon DJ, Schimmer BP 1991 Regulation of adenylyl cyclase activity by β-adrenergic agonists in a desensitization-resistant mutant cell line. Mol Endocrinol 5:34-41
16. 1 receptor in Y1 adrenal cells and in a desensitization-resistant Y1 mutant. Mol Endocrinol 6:1095-1102
17. Neer EJ 1995 Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80:249-257
18. Simonds WF, Butrynski JE, Gautam N, Unson CG, Spiegel AM 1991 G-protein βγ dimers: membrane targeting requires subunit coexpression and intact γ C-A-A-X domain. J Biol Chem 266:5363-5366
19. Garica-Higuera I, Fenoglio J, Li Y, Lewis C, Panchenko MP, Reiner O, Smith TF, Neer EJ 1996 Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein β subunit. Biochemistry 35:13985-13994
20. Wong M, Schimmer BP 1989 Recovery of responsiveness to ACTH and cAMP in a protein kinase-defective adrenal cell mutant following transfection with a protein kinase gene. Endocr Res 15:49-65
21. Wong M, Rice DA, Parker KL, Schimmer BP 1989 The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11β-hydroxylase genes in mouse adrenocortical tumor cells. J Biol Chem 264:12867-12871
22. Schmidt CJ, Thomas TC, Levine MA, Neer EJ 1992 Specificity of G protein β and γ subunit interactions. J Biol Chem 267:13807-13810
23. Iñiguez-Lluhi JA, Simon MI, Robishaw JD 1992 G protein βγ subunits synthesized in Sf9 cells: functional characterization and the significance of prenylation of γ. J Biol Chem 267:23409-23417
24. Ueda N, Iñiguez-Lluhi JA, Lee E, Smrcka AV, Robishaw JD, Gilman AG 1994 G protein βγ subunits: simplified purification and properties of novel isoforms. J Biol Chem 269:4388-4395
25. Wong M, Krolczyk AJ, Schimmer BP 1992 The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions. Mol Endocrinol 6:1614-1624
26. Tesmer JJG, Sunahara RK, Gilman AG, Sprang SR 1997 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα.GTPγS. Science 278:1097-1916
27. Schimmer BP, Tsao J 1990 Decreased levels of guanyl nucleotide-binding regulatory protein α-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin. Mol Endocrinol 4:1698-1703
28. s. J Biol Chem 262:15521-15526
29. Crespo P, Xu N, Simonds WF, Gutkind JS 1994 Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature 369:418-420
30. Southern PJ, Berg P 1978 Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Appl Genet 1:327-340
31. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299
32. D'Aquila RT, Bechtel LJ, Videler JA, Eron JJ, Gorczyca P, Kaplan JC 1991 Maximizing sensitivity and specificity of PCR by preamplification heating. Nucleic Acids Res 19:3749
33. Schimmer BP, Zimmerman AE 1976 Steroidogenesis and extracellular cAMP accumulation in adrenal tumor cell cultures. Mol Cell Endocrinol 4:263-270
34. Lowry OH, Rosebrough NF, Farr AL, Randall RJ 1951 Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
35. Schimmer BP 1979 Adrenocortical Y1 cells. Methods Enzymol 52:570-574
36. Yasumura Y, Buonassisi V, Sato G 1966 Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype. Cancer Res 26:529-535
37. Schimmer BP 1969 Phenotypically variant adrenal tumor cell cultures with biochemical lesions in the ACTH-stimulated steroidogenic pathway. J Cell Physiol 74:115-122
38. Graham FL, van der Eb AJ 1973 A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467
39. Handler JD, Schimmer BP, Flynn TR, Szyf M, Seidman JG, Parker KL 1988 An enhancer element and a functional cyclic AMP-dependent protein kinase are required for expression of adrenocortical 21-hydroxylase. J Biol Chem 263:13068-13073
40. Feigner PL, Gaek TR, Holm M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM, Danielsen M 1987 Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84:7413-7417
41. de Wet JR, Wood KV, DeLuca M, Helinski dR, Subramani S 1987 Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol 7:725-737