Isolation and partial structure determination of a clonidine-displacing substance from bovine lung and brain

Journal of the Autonomic Nervous System

Volumn 72, Issue 2-3, 1998, Pages 86-93

  Grigg, Matthew ^a   Musgrave, Ian F ^b   Barrow, Colin J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Brain; CDS; Clonidine; Imidazoline; Isolation; Lung

Indexed keywords

CLONIDINE; CLONIDINE DISPLACING SUBSTANCE; GUANOSINE; HEXANE; LIPID; METHANOL;

ANIMAL TISSUE; BIOASSAY; BRAIN TISSUE; CATTLE; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CONFERENCE PAPER; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; ISOLATION AND PURIFICATION; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CATTLE; CEREBRAL CORTEX; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CLONIDINE; LIGANDS; LUNG; MAGNETIC RESONANCE SPECTROSCOPY; RATS;

EID: 0031754452     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(98)00092-7     Document Type: Conference Paper

References (30)

1. Anis, N., Sherby, S., Goodnow, R. Jr., Niwa, M., Konno, K., Kallimopoulos, T., Bukownik, R., Nakanishi, K., Usherwood, P., Elderfrawi, A., 1990. Structure activity relationships of philanthotoxin analogs and polyamines of N-methyl-D-aspartate and nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 254, 764-773.
2. Atlas, D., Burnstein, Y., 1984. Isolation and partial purification of a clonidine displacing endogenous brain substance. Eur. J. Biochem. 144, 287-293.
3. Atlas, D., Diamant, S., Fales, H.M., Pannell, L., 1987. The brain's own clonidine. Purification and characterisation of endogenous clonidine displacing substance from brain. J. Cardiovasc. Pharmacol. 10, S122-127, Suppl. 12.
4. Atlas, D., Diamant, S., Zonnenschein, R., 1992. Is the imidazoline site a unique receptor? A correlation with clonidine displacing substance activity. Am. J. Hypertens. 5, 83S-90S.
5. Bousquet, P., Bricca, G., Dontenwill, M., Feldman, J., Greney, H., Belcourt, A., Stutzmann, J., 1992. From the alpha-2-adrenoceptors to the imidazole preferring receptors. Fundam. Clin. Pharmacol. 6, 15S-21S, Suppl 1.
6. 1) receptors in modulating aqueous humor dynamics. J. Ocul. Pharmacol. 10, 393-402.
7. 50) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108.
8. 2-adrenoceptors in the human central nervous system. Neuroscience 59, 589-598.
9. Diamant, S., Atlas, D., 1986. An endogenous brain substance CDS inhibits the twitch response of rat vas deferens. Biochem. Biophys. Res. Commun. 134, 184-190.
10. Ernsberger, P., Giuliano, R., Willette, R.N., Granata, A.R., Reis, D.J., 1988. Role of clonidine analogues correlates with binding affinity at imidazole and not alpha-2-adrenergic receptors in the rostral ventrolateral medulla. J. Hypertens. Suppl. 6, S554-557.
11. Ernsberger, P., Graves, M.E., Graff, L.M., Zakieh, N., Nguyen, P., Collins, L.A., Westbrooks, K.L., 1995a. Definition, characterisation, distribution and transmembrane signalling. Ann. N.Y. Acad. Sci. 763, 22-42.
12. 1-imidazoline sites. Ann. N.Y. Acad. Sci. 763, 163-168.
13. 1-imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br. J. Pharmacol. 114, 751-754.
14. Gogstad, G.O., Krutnes, M.B., 1982. Measurement of protein in cell suspensions using the Coomassie brilliant blue dye binding assay. Anal. Biochem. 126, 355-359.
15. Goldberg-Stern, H., Atlas, D., Schwartz, L., Achiron, A., Ziv, I., Djaldetti, R., Zoldan, Y., Melamed, E., 1993. Detection and measurement of an endogenous clonidine displacing substance in human cerebrospinal fluid. Brain Res. 601, 325-328.
16. Gomez, R.E., Ernsberger, P., Feinland, G., Reis, D.J., 1991. Rilmenidine lowers arterial pressure via imidazoline receptors in the brainstem C1 area. Eur. J. Pharmacol. 195, 181-191.
17. 3H]rilmenidine binding in rat brain and kidney. Ann. N.Y. Acad. Sci. 763, 194-207.
18. Li, G., Regunathan, S., Barrow, C.J., Esharaghi, J., Cooper, R., Reis, D.J., 1994. Agmatine: an endogenous clonidine displacing substance in brain. Science 263, 966-969.
19. Loring, R.H., 1990. Agmatine acts as an antagonist of neuronal nicotinic receptors. Br. J. Pharmacol. 99, 207-211.
20. Meeley, M.P., Ernsberger, P.R., Granata, A.R., Reis, D.J., 1986. An endogenous clonidine displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla. Life Sci. 38, 1119-1126.
21. Mermet, C., Quintin, L., 1991. Effect of clonidine on catechol metabolism in the rostral ventrolateral medulla: an in vivo electrochemical study. Eur. J. Pharmacol. 204, 105-107.
22. Michel, M.C., Ernsberger, P., 1992. Keeping an eye on the I site: imidazoline preferring receptors. Trends Pharmacol. Sci. 13, 369-370.
23. 3H]clonidine binding sites in rat stomach: high affinity of imidazolines, guanadines and sigma ligands. Naunyn-Schmiedeberg's Arch. Pharmacol. 351, 561-564.
24. Piletz, J.E., Chikkala, D.N., Ernsberger, P., 1995. Comparison of properties of agmatine and endogenous clonidine displacing substance at imidazoline and alpha-2-adrenergic receptors. J. Pharmacol. Exp. Ther. 272, 581-587.
25. Reis, D.J., Regunathan, S., Meeley, M.P., 1992. Imidazoline receptors and clonidine displacing substance in relationship to control of blood pressure; neuroprotection; and adrenomedullary secretion. Am. J. Hypertens. 5, 51S-57S.
26. Singh, G., Hussain, J.F., MacKinnon, A., Brown, C.M., Kendall, D.A., Wilson, V.G., 1995. Evidence for the presence of a non-catecholamine clonidine displacing substance in crude methanolic extracts of bovine lung and brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 351, 17-26.
27. Smyth, D.D., Darkwa, F.K., Penner, S.B., 1995. Imidazoline receptor and sodium excretion in rat kidney. Ann. N.Y. Acad. Sci. 763, 340-352.
28. Synestos, D., Manolopoulos, V.G., Atlas, D., Pipili-Synestos, E., 1991. Human plasma derived material with clonidine displacing substance (CDS) like properties contracts the isolated rat aorta. J. Auton. Pharmacol. 11, 343-351.
29. Tesson, F., Prip-Buus, C., Lemoine, A., Pegorier, J.P., Parini, A., 1991. Subcellular distribution of imidazoline-guanadinium receptive sites in human and rabbit liver. Major localisation to the mitochondrial outer layer. J. Biol. Chem. 266, 155-160.
30. Tibirica, E., Feldman, J., Mermet, C., Monassier, L., Gonon, F., Bousquet, P., 1991. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline preferring receptors. Eur. J. Pharmacol. 209, 213-221.