Simple methods for the labelling of N-methyl amines using isotopically labelled methyl iodide

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 12, 1998, Pages 1127-1143

  Fellows, Ian ^a   Carr, Richard M ^a   DeBoeck, Nigel ^a   Montgomery, Stephen ^a   Waterhouse, Ian ^a   Sutherland, Derek R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Amines; Demethylation; Isotopic labelling; N methyl; Quaternisation

Indexed keywords

CHEMICAL REACTIONS; ISOTOPES;

DEMETHYLATION; ISOTOPIC DILUTION; ISOTOPIC LABELING; ISOTOPICALLY LABELED; METHYL AMINE; METHYL IODIDE; N-METHYL; QUATERNIZATION; SIMPLE METHOD;

AMINES;

AMINE; METHYL IODIDE; QUATERNARY AMMONIUM DERIVATIVE;

ARTICLE; ISOTOPE LABELING;

EID: 0031753884     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199812)41:12<1127::AID-JLCR158>3.0.CO;2-9     Document Type: Article

References (13)

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10. Prepared by permethylation of the corresponding primary amine with trideuteromethyl iodide. Followed by demethylation of the resultant quaternary salt with DABCO in NMP.
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