Intermediary metabolism of pentachloronitrobenzene in the control and germfree rat and rat with cannulated bile ducts

Xenobiotica

Volumn 28, Issue 10, 1998, Pages 973-984

  Larsen, G L ^a   Huwe, J K ^a   Bakke, J E ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BENZENE DERIVATIVE; CARBON 14; GLUTATHIONE; GLUTATHIONE DERIVATIVE; QUINTOZENE; S (AMINOTETRACHLOROPHENYL)GLUTATHIONE; TETRACHLOROBIS(METHYLTHIO)BENZENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; BILE DUCT; BILIARY EXCRETION; CONJUGATION; GERMFREE ANIMAL; MALE; METABOLISM; METABOLITE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALIA;

EID: 0031753882     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982598239038     Document Type: Article

References (22)

1. ASCHBACHER, P. W. and FEIL, V. J., 1983, Metabolism of pentachloronitrobenzene by goats and sheep. Journal of Agricultural and Food Chemistry, 31, 1150-1158.
2. BAKKE, J. E., ASCHBACHER, P. W., FEIL, V. J. and GUSTAFSSON, B. E., 1981, The metabolism of pentachloromethylthiobenzene in germ-free and conventional rats. Xenobiotica, 11, 173-178.
3. BAKKE, J. E., FEIL, V. J. and PRICE, C. E., 1976, Rat urinary metabolites from O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate. Journal of Environmental Science and Health, B11, 225-230.
4. BAKKE, J. E., FEIL, V. J. and ZAYLSKIE, R. G., 1989, Isotope dilution assay for urinary methanesulfinic and methanesulfonic acids: application to detection of methylthio turnover. Biomedical and Environmental Mass Spectrometry, 18, 1096-1098.
5. BAKKE, J. E., GUSTAFSSON, J.-A. and GUSTAFSSON, B. E., 1980, Metabolism of propachlor by the germfree rat. Science 210, 433-435.
6. BAKKE, J. E., MULFORD, D. J., HUWE, J. K., FEIL, V. J. and DAVISON, K. L., 1993, Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rats. Xenobiotica, 23, 949-960.
7. BOLLMAN, J. L., 1948, A cage which limits the activity of rats. Journal of Laboratory and Clinical Medicine, 33, 1348.
8. DUGGAN, D. E. and KWAN, K. C., 1979, Enterohepatic recirculation of drugs as a determinant of therapeutic ratio, Drug Metabolism Reviews, 9, 21-41.
9. GOLDMAN, P., 1989, Germ-free rats in the study of the metabolism of xenobiotic compounds. In Intermediary Xenobiotic Metabolism in Animals, edited by D. H. Hutson, V. Caldwell and G. D. Paulson (London: Taylor & Francis), pp. 263-276.
10. HUWE, J. K., FEIL, V. J., BAKKE, J. E. and MULFORD, D. J., 1991, Studies on the displacement of methylthio groups by glutathione. Xenobiotica, 21, 179-191.
11. 14C in Khesus monkeys after single and chronic oral administration. Chemosphere, 8, 97-105.
12. LARSEN, G. L., 1985, Distribution of cysteine conjugate β-lyase in gastrointestinal bacteria and in the environment. Xenobiotica, 15, 199-209.
13. LARSEN, G. L. and BAKKE, J. E., 1981, Enterohepatic circulation in formation of propachlor (2-chloro-N-isopropylacetanilide) metabolites in the rat. Xenobiotica, 11, 473-480.
14. MULFORD, D. J., BAKKE, J. E. and FEIL, V. J., 1991, Glutathione-S-transferase-mediated methylthio-displacement and -turnover in the metabolism of pentachlorothioanisole by rats. Xenobiotica, 21, 597-603.
15. 14C-labelled pentachloronitrobenzene in Osborne-Mendell rats, Chemosphere, 10, 67-72.
16. PAULSON, G. D., MITCHELL, A. D. and ZAYLSKIE, R. G., 1985, Identification and quantitation of sulfamethazine metabolites by liquid chromatography and gas chromatography-mass spectrometry. Journal of the Association of Official Analytical Chemists, 68, 1000-1006.
17. QUIRIJINS, J. K., VAN DER PAAUW, C. G., TEN NOEVER DE BRAUW, M. C. and DE VOS, R. H., 1979, Survey of the contamination of Dutch coastal waters by chlorinated hydrocarbons, including the occurrence of methylthiopentachlorobenzene and di-(methylthio)tetrachlorobenzene. Science of the Total Environment, 13, 225-233.
18. RENNER, G., 1980, Metabolic studies on pentachloronitrobenzene (PCNB) in rats. Xenobiotica, 10, 537-550.
19. SAMARA, F., BIALER, M. and HARVEY, D. J., 1990, Identification of glucose conjugates as major urinary metabolites of cannabidiol in the dog. Xenobiotica, 20, 177-183.
20. SOINE, W. H., SOINE, P. J., MONGRAIN, S. E. and ENGLAND, T. M., 1990, Stereochemical characterization of the diastereomers of the phenobarbital N-beta-D-glucose conjugate excreted in human urine. Pharmacological Research, 7, 402-406.
21. TREXLER, P. C. and REYNOLDS, L. I., 1957, Flexible film apparatus for the rearing and use of germ-free animals. Applied Microbiology, 5, 406-412.
22. WEISIGER, R. A., PINKUS, L. M. and JAKOBY, W. B., 1980, Thiol S-methyltransferase: suggested role in detoxification of intestinal hydrogen sulfide. Biochemical Pharmacology, 29, 2885-2887.