ET-1 modulates K(Ca)-channel activity and arterial tension in normoxic and hypoxic human pulmonary vasculature

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 275, Issue 4 19-4, 1998, Pages

  Peng, Wei ^a   Michael, John R ^a   Hoidal, John R ^a   Karwande, S V ^a   Farrukh, Imad S ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

BQ 123; Calcium activated potassium channel; Chronic hypoxia; Endothelin 1; Human lung; Potassium currents; Pulmonary hypertension

Indexed keywords

CALCIUM ION; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; POTASSIUM ION;

AMPLITUDE MODULATION; ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; LUNG BLOOD FLOW; POTASSIUM CURRENT; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER;

EID: 0031753696     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1998.275.4.l729     Document Type: Article

References (11)

1. Archer, S. L., J. M. C. Huang, V. Hampl, D. P. Nelson, P. J. Shultz, and E. K. Weir. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K-channel by cGMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 91: 7583-7587, 1994.
2. Berman, D. M., and W. F. Golman. Stored calcium modulates inositol phosphate synthesis in cultured smooth muscle cells. Am. J. Physiol. 263 (Cell Physiol. 32): C535-C539, 1992.
3. Bonvallet, S. T., M. Oka, M. Yano, M. R. Zamora, I. F. McMurtry, and T. J. Stelzner. BQ123, an ETA receptor antagonist attenuates endothelin-1-induced vasoconstriction in rat pulmonary circulation. J. Cardiovasc. Pharmacol. 22: 39-43, 1993.
4. A-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1327-H1331, 1994.
5. A-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L690-L697, 1995.
6. Douglas, S. A., L. M. Vickery-Clark, and E. H. Ohlstein. Endothelin-1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: effect of BQ-123. Br. J. Pharmacol. 108: 418-421, 1993.
7. Fabiato, A. Computer programs for calculating total from specific free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods Enzymol. 157: 378-417, 1988.
8. +-channel opener. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L186-L195, 1998.
9. + channel blockers on vascular tone in perfused rat lung. Am. Rev. Respir. Dis. I144: 884-887, 1991.
10. Hasunuma, K., D. M. Rodman, R. F. O'Brien, and I. F. McMurtry. Endothelin-1 causes pulmonary vasodilation in rats. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H48-H54, 1990.
11. + channel in smooth muscle cells of porcine coronary artery. Eur. J. Pharmacol. 194: 31-36, 1991.