The synthesis of labelled forms of saquinavir

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 12, 1998, Pages 1103-1126

  Wiltshire, H R ^c   Prior, K J ^c   Dhesi, J ^c   Trach, F ^a   Schlageter, M ^b   Schonenberger H ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Roche Discovery Welwyn ^*

^c ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

AIDS; Saquinavir; Stable labels; 125I ; 14C ; 3H

Indexed keywords

BIOLOGICAL MATERIALS;

AIDS; ANALYTICAL METHOD; BIOLOGICAL FLUIDS; HIV-PROTEASE INHIBITORS; MEASUREMENTS OF; SAQUINAVIR; STABLE LABEL; [125I]; [14C]; [3H];

ISOTOPES;

CARBON 14; DEUTERIUM; IODINE 125; NITROGEN; PROTEINASE INHIBITOR; SAQUINAVIR; STABLE ISOTOPE; TRACER; TRITIUM;

ANALYTIC METHOD; ARTICLE; BIOEQUIVALENCE; BODY FLUID; DRUG BLOOD LEVEL; DRUG LABELING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; RADIOIMMUNOASSAY;

EID: 0031753395     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199812)41:12<1103::AID-JLCR157>3.0.CO;2-M     Document Type: Article

References (8)

1. Perry C M, Noble S. - Saquinavir Soft-Gel Capsule Formulation. A review of its use in patients with HIV infection. Drugs, 55, 461-486, (1998 ).
2. Knebel N G, Sharp S R, Madigan M J.- Quantification of the Anti-HIV Drug Saquinavir by High-speed On-line High-performance Liquid Chromatography/Tandem Mass Spectrornetry. J. Mass Spectrometry, 30: 1149-1156 (1995).
3. Martin, J.A., Redshaw S.A. - British Patent Application 89279137.
4. Vogel's Textbook of Practical Organic Chemistry, Fifth Edition. Longmans Scientific and Technical Publications, 1989, page 1187.
5. Vogel's Textbook of Practical Organic Chemistry, Fifth Edition. Longmans Scientific and Technical Publications, 1989, page 1062.
6. Campbell K N, Schaffner I J. - J. Amer. Chem. Soc. 67, 86-89, (1945).
7. Song Z, Mertzman M, Hughes D L. - J. Heterocyclic Chemistry, 30: 17-21 (1903).
8. Fitzsimmons M E, Collins J M,- Drug Metabolism and Disposition. 25: 256-266 (1997).