Effects of autonomic neuropathy on counterregulation and awareness of hypoglycemia in type 1 diabetic patients

Diabetes Care

Volumn 21, Issue 11, 1998, Pages 1960-1966

  Meyer, Christian ^a,b   Großmann, Ralf ^b   Mitrakou, Asimina ^b   Mahler, Ralf ^b   Veneman, Thiemo ^b   Gerich, John ^b   Bretzel, Reinhard G ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CATECHOLAMINE; GLUCAGON; GROWTH HORMONE; HYDROCORTISONE; NORADRENALIN;

ADULT; ARTICLE; AUTONOMIC NEUROPATHY; AWARENESS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PATHOPHYSIOLOGY; RISK FACTOR; SCORING SYSTEM;

ADULT; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; FEMALE; GLUCAGON; HUMANS; HYDROCORTISONE; HYPOGLYCEMIA; INSULIN; MALE; NOREPINEPHRINE; PERCEPTION;

EID: 0031752991     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.21.11.1960     Document Type: Article

References (40)

1. Cryer P: Banting Lecture: hypoglycemia, the limiting factor in the management of IDDM. Diabetes 43:1378-1389, 1994
2. DCCT Research Group: Epidemiology of severe hypoglycemia in the Diabetes Control and Complications Trial. Am J Med 90:450-459, 1991
3. White NH, Skor DA, Cryer PE, Bier DM, Levandoski L, Santiago JV: Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308:485-491, 1983
4. Bolli GB, DeFeo P, DeCosmo S, Perriello G, Ventura MM, Benedetti MM, Santeusanio F, Gerich JE, Brunetti P: A reliable and reproducible test for adequate glucose counter-regulation in type I diabetes mellitus. Diabetes 33:732-737, 1984
5. Sjöborn N, Adamson U, Lins P-E: The prevalence of impaired glucose counter-regulation during an insulin-infusion test in insulin-treated diabetic patients prone to severe hypoglycemia. Diabetologia 32:818-825, 1989
6. Gerich J, Mokan M, Veneman T, Korytkowski M, Mitrakou A: Hypoglycemia unawareness. Endocr Rev 12:356-371, 1991
7. Hepburn D, Patrick A, Eadington D, Ewing D, Frier B: Unawareness of hypoglycemia in insulin-treated diabetic patients: prevalence and relationship to autonomic neuropathy. Diabet Med 7:711-717, 1990
8. Amiel S, Tamborlane W, Simonson D, Sherwin R: Defective glucose counterregulation after strict control of insulin-dependent diabetes mellitus. N Engl J Med 316:1376-1383, 1987
9. Amiel S, Sherwin R, Simonson D, Tamborlane W: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907, 1988
10. Boyle P, Schwartz N, Shah S, Clutter W, Cryer P: Plasma glucose concentrations at the onset of hypoglycemic symptoms in patients with poorly controlled diabetes and in nondiabetics. N Engl J Med 318:1487-1492, 1988
11. Gerich J, Langlois M, Noacco C, Karam J, Forsham P: Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 182:171-173, 1973
12. Bolli G, DeFeo P, Compagnucci P, Cartechini M, Angeletti G, Santeusanio F, Brunetti P, Gerich J: Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32:134-41, 1983
13. Popp D, Shah S, Cryer P: The role of epinephrine-mediated beta-adrenergic mechanisms in hypoglycemic glucose counterregulation and posthypoglycemic hyperglycemia in insulin-dependent diabetes mellitus. J Clin Invest 69:315-326, 1982
14. Mühlhauser I, Heinemann L, Fritsche E, vonLennep K, Berger M: Hypoglycemic symptoms and frequency of severe hypoglycemia in patients treated with human and animal insulin preparations. Diabetes Care 14:745-749, 1991
15. Polinsky RJ, Kopin IJ, Ebert MM, Weisse V: The adrenal medullary response to hypoglycemia in patients with orthostatic hypotension J Clin Endocrinol Metab 51:1401-1406, 1980
16. Hilsted J, Masbad S, Krarup T, Sesloft L, Christensen J, Tromier B, Galbo H: Hormonal, metabolic and cardiovascular responses to hypoglycemia in diabetic autonomie neuropathy, Diabetes 30:626-633, 1981
17. Hoeldtke R, Boden G, Shuman C, Owen C: Reduced epinephrine secretion and hypoglycemic unawareness in diabetic autonomie neuropathy Ann Intern Med 96:459-462, 1982
18. Adamson V, Lins P, Efendic S, Hamberger B, Wajngot A: Impaired eounterregulation of hypoglycemia in a group of insulin-dependent diabetics with recurrent episodes of severe hypoglycemia. Acta Med Scand 216:215-222, 1984
19. Horie H, Hanafusa T, Matsuyama T, Namba M, Nonaka K, Tarui S, Yamatodani A, Wada H: Decreased response of epinephrine and norepinephrine to insulin-induced hypoglycemia in diabetic autonomic neuropathy Horm Metab Res 16:398-401, 1984
20. White N, Gingerich R, Levandoski L, Cryer P, Santiago J: Plasma pancreatic polypeptide response to insulin-induced hypoglycemia as a marker for defective glucose counterregulation in insulin-dependent diabetes mellitus. Diabetes Care 34:870-875, 1985
21. Hepburn DA, MacLeod KM, Frier BM: Preservation of symptomatic and physiologic responses to hypoglycemia in diabetic patients with autonomie neuropathy (Abstract). Diabetes 41:58A, 1992
22. Nakamura T, Takebe K, Kudoh K, Ishii M, Imamura K-I, Kiruchi H, Kasai F, Tandon Y, Yamada N, Arai Y, Terada A, Machida K: Decreased counterregulatory hormone responses to insulin-induced hypoglycemia in patients with pancreatic diabetes having autonomic neuropathy. Tohoku J Exp Med 174:305-315, 1994
23. Bottini P, Boschetti E, Pampanelli S, Ciofetta M, Del Sindaco P, Scionti L, Brunetti P, Bolli GB: Contribution of autonomic neuropathy to reduced plasma adrenalin responses to hypoglycemia in IDDM: evidence for a nonselective defect. Diabetes 46:814-823, 1997
24. Fanelli C, Pampanelli S, Lalli C, Del Sindaco P, Ciofetta M, Lepore M, Porcellati F, Bottini R Di Vincenzo A, Brunetti P, Bolli GB: Long-term intensive therapy of IDDM patients with clinically overt autonomic neuropathy: effects on hypoglycemia awareness and cunterregulation. Diabetes 46:1172-1181, 1997
25. Ryder R, Owens D, Hayes T, Ghatei M, Bloom S: Unawareness of hypoglyeaemia and inadequate hypoglycaemic counterregulation: no casual relation with diabetic autonomic neuropathy. BMJ 301:783-787, 1990
26. Huffman R, Singer-Granik C, Drash A, Becker D: Plasma catecholamine responses to hypoglycemia in children and adolescents with IDDM, Diabetes Care 14:81-88, 1991
27. Dagogo-Jack S, Craft S, Cryer P: Hypoglycemia-associated autonomie failure in insulin dependent diabetes mellitus. J Clin Invest 91:819-828, 1993
28. Stephenson JM, Kempler P, Cavallo Perin P, Fuller JH: Is autonomic neuropathy a risk factor for severe hypoglycaemia? The EURODIAB IDDM Complications Study. Diabetologia 39:1372-1376, 1996
29. Ewing DJ, Martyn CN, Young RJ, Clarke BF: The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 8:491-498, 1985
30. Dyck PJ, Karnes JL, Daube J, O'Brian P, Service FJ: Clinical and neuropathological criteria for the diagnosis and staging of diabetic polyneuropathy Brain 108:861-880, 1985
31. Dyck PJ, Zimmerman IR, O'Brian PC, Ness A, Caskey PE, Karnes J, Bushek W: Introduction of automated systems to evaluate touch-pressure, vibration and thermal cutaneous sensation in man. Ann Neurol 4:502-510, 1978
32. Dyck PJ, Karnes J, O'Brian PC, Zimmerman IR: Detection thresholds of cutaneous sensation in humans. In Peripheral Neuropathy. Dyck PJ, Thomas PK, Lambert EH, Bunge R, Eds. Philadelphia, WB Saunders, 1984, p. 1103-1138
33. The Diabetes and Complications Trial Research Group: Hypoglycemia in the Diabetes Control and Complications Trial. Diabetes 46:271-286, 1997
34. Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J: Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260:E67-E74, 1991
35. Andres R, Swerdloff R, Pozefsky T, Coleman D: Manual feedback technique for the control of blood glucose concentration, In Automation in Analytical Chemistry. Skeggs L, Ed. Mediad, White Plains, NY, 1966, p. 486-491
36. Hepburn D, Deary I, Frier B: Classification of symptoms of hypoglycemia in insulintreated diabetic patients using factor analysis: relationship to hypoglycemia unawareness. Diabet Med 9:70-75, 1992
37. Towler D, Havlin C, Craft S, Cryer P: Mechanism of awareness of hypoglycemia: perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 42:1791-1798, 1993
38. Binkiewicz A, Sadeghi-Nijad A, Hochman H, Loridan L, Senior B: An effect of ketones on the concentrations of glucose and of free fatty acids in man independent of the release of insulin. J Pediatr 84:226-231, 1974
39. Fanelli CG, De Feo P, Porcellati F, Perriello G, Torlone E, Santeusanio F, Brunetti P, Bolli GB: Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis. J Clin Invest 89:2005-2013, 1992
40. Gerich J: Glucose counterregulation and its impact on diabetes mellitus. Diabetes 37:1608-1617, 1988