The expression of mdr-1 -related gp-170 and its correlation with anthracycline resistance in renal cell carcinoma cell lines and multidrug-resistant sublines

British Journal of Urology

Volumn 82, Issue 4, 1998, Pages 544-547

  Yu, D S ^a   Chang, S Y ^a   Ma, C P ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Anthracycline; Drug resistance; gp 170; MDR sublines; mdr 1 gene; Renal cell carcinoma

Indexed keywords

ANTHRACYCLINE; DOXORUBICIN; EPIRUBICIN; GLYCOPROTEIN; GLYCOPROTEIN GP 170; UNCLASSIFIED DRUG;

ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG RESISTANCE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, RENAL CELL; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; KIDNEY NEOPLASMS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED;

EID: 0031752659     PISSN: 00071331     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410x.1998.00796.x     Document Type: Article

References (17)

1. Fojo AT. Ueda K. Slamon DJ, Poplack DG. Gottesman MM, Pastan I. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Nad Acad Sei USA 1987: 84: 265-9
2. Kartner N, Riordan JR, Ling. V. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 1983: 221: 1285-8
3. Dalton WS. Durie BGM, Alverto DS, Gerlack JH, Cress AE. Characterization of a new drug-resistance human myeloma cell line that express P-glycoprotein. Cancer Res 1986: 46: 5125-30
4. Hamada H. Tsuruo T. Characterization of the ATPase activity of Mr 170000-180000 membrane glycoprotein associated with multidrug resistance in K562JADM cells. Cancer Res 1988; 48: 4926-32
5. Riordan JR, Ling V. Genetic and biochemical characterization of multidrug resistance. Pharmacol Ther 1985: 28: 51-7
6. Cornwell MM. Gottesman MM, Pastan I. Increased vinblastine binding to membrane vesicles from multi-drug resistant KB cells. }Biol Chem 1986; 261: 2917-8
7. Roninson IB. Molecular mechanism of multidrug resistance in tumor cells. Clin Physiol Biochem 1987; 5: 140-51
8. Vugrin D. Systemic therapy of metastatic renal cell carcinoma. Sem Nephrol 1987: 7: 152-5
9. Benson MC, Giella J, Whang IS et al Flow cytometric determination of the multidrug resistance phenotype in transitional cell cancer of the bladder: implications and applications. J Urol 1991: 146: 982-7
10. Carmichael }. DeGraff WG. Gazdar AF. Minna JD, Michail JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987: 47: 936
11. Mickisch GH. Koessig J. Keilhauer GK, Schlick E. Tschada R. Alken FM. Effects of calcium antagonists in multidrug resistant primary human renal cell carcinomas. Cancer Res 1990: 50: 3670-4
12. Mickisch GH. Roehrich K. Koessig J. Forster S, Tschada RK, Alken PM. Mechanisms and modulation of multidrug resistance in primary human renal cell carcinoma. J Urol 1990: 144: 755-9
13. 3 Mickisch GH, Kossig J. Tschada RK. Keilhauer G. Schlick E, Alken PM. Circumvention of multidrug resistance mediated by p-170 glycoprotein using calcium antagonists in primary human renal cell carcinoma. Ural hit 1991: 47: 118-21
14. Mickisch G. Bier H. Tschada R. Alkein P. Effects of buthionine sulfoximine mediated glutathione depletion in chemoresistant human renal cell carcinomas. In ]ocham D, Thuroff JW. Rubben H, eds. Investigative Urology. Berlin: Springer-Verlag. 1992: 21
15. Thiebaut F. Tsuruo T. Hamada H. Gottesman MM. Pastan I. Willingham MC. Cellular localization of the multidrugresistance gene product p-glycoprotein in normal human tissues. Proe Natl Acad Sei USA 1987: 84: 773S-N
16. Yu DS. Chang SY. Yang TH. Cheng I'M. The expression of MDR-1-related glycoprotein (gp-170) in normal kidney tissue and renal cell carcinoma. J Sury Assoc ROC 1997: 30: 143-8
17. Naito S. Kotoh S. Goto K et al. Establishment of two human renal cell carcinoma cell lines with different chcmosensitivity. Hum Cell 1996; 9: 101-8