Leishmania mexicana: Extracellular proton concentration is a key regulator of cysteine proteinase CPb expression

Experimental Parasitology

Volumn 90, Issue 1, 1998, Pages 58-64

  Ke, Genping ^a   Mauël, Jacques ^b   Rivier, Denis ^b  

^a MASSEY UNIVERSITY   (New Zealand)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

AU, arbitrary units; BSA, bovine serum albumin; CP, cysteine proteinase; Cysteine proteinase; DTT, dithiothreitol; EDTA, ethylene diamine tetraacetate; FCS, fetal calf serum; Leishmania; pH stress; SDS PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; TBS, Tris buffer saline; Z F R AMC, benzyloxycarbonyl phenylalanyl arginyl 7 amino 4 methylcoumarin

Indexed keywords

CYSTEINE PROTEINASE;

AMASTIGOTE; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; LEISHMANIA MEXICANA; NONHUMAN; PARASITE DEVELOPMENT; PH; PRIORITY JOURNAL; PROMASTIGOTE;

BOVINAE; LEISHMANIA MEXICANA; PROTOZOA;

EID: 0031752453     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1006/expr.1998.4310     Document Type: Article

References (31)

1. Alexander, J. 1981. Leishmania mexicana: Inhibition and stimulation of phagosome-lysosome fusion in infected macrophages. Experimental Parasitology 52, 261-270.
2. Antoine, J. C., Prina, E., Jouanne, C., and Bongrand, P. 1990. Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH. Infection & Immunity 58, 779-787.
3. Ashford, R. W., Desjeux, P., and deRaadt, P. 1992. Estimation of population at risk of infection and number of cases of leishmaniasis. Parasitology Today 8, 104-105.
4. Bahr, V., Stierhof, Y. D., Ilg, T., Demar, M., Quinten, M., and Overath, P. 1993. Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana. Molecular & Biochemical Parasitology 58, 107-121.
5. Berens, R. L., and Marr, J. J. 1978. An easily prepared defined medium for cultivation of Leishmania donovani promastigotes. Journal of Parasitology 64, 160.
6. Bijovsky, A. T. 1994. Leishmania mexicana: the influence of slightly elevated temperature on the ultrastructure of axenic amastigote-like forms. Parasitology Research 80, 696-698.
7. De Souza Leao, S., Lang, T., Prina, E., Hellio, R., and Antoine, J. C. 1995. Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells. Journal of Cell Science 108, 3219-3231.
8. Duboise, S. M., Vannier-Santos, M. A., Costa-Pinto, D., Rivas, L., Pan, A. A., Traub-Cseko, Y., De Souza, W., and McMahon-Pratt, D. 1994. The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases. Molecular & Biochemical Parasitology 68, 119-132.
9. Glaser, T. A., Baatz, J. E., Kreishman, G. P., and Mukkada, A. J. 1988. pH homeostasis in Leishmania donovani amastigotes and promastigotes. Proceedings of the National Academy of Sciences of the United States of America 85, 7602-7606.
10. Glaser, T. A., Wells, S. J., Spithill, T. W., Pettitt, J. M., Humphris, D. C., and Mukkada, A. J. 1990. Leishmania major and L. donovani: A method for rapid purification of amastigotes. Experimental Parasitology 71, 343-345.
11. Glaser, T. A., Utz, G. L., and Mukkada, A. J. 1992. The plasma membrane electrical gradient (membrane potential) in Leishmania donovani promastigotes and amastigotes. Molecular & Biochemical Parasitology, 51, 9-15.
12. Ilg, T., Fuchs, M., Gnau, V., Wolfram, M., Harbecke, D., and Overath, P. 1994. Distribution of parasite cysteine proteinases in lesions of mice infected with Leishmania mexicana amastigotes. Molecular & Biochemical Parasitology 67, 193-203.
13. Jiang, S., Anderson, S. A., Winget, G. D., and Mukkada, A. J. 1994. Plasma membrane K+/H(+)-ATPase from Leishmania donovani. Journal of Cellular Physiology 159, 60-66.
14. Klamo, E. M., Drew, M. E., Landfear, S. M., and Kavanaugh, M. P. 1996. Kinetics and stoichiometry of a proton/myo-inositol cotransporter. Journal of Biological Chemistry 271, 14937-14943.
15. Leon, L. L., Temporal, R. M., Soares, M. J., and Grimaldi Junior, G. 1994. Proteinase activities during temperature-induced stage differentiation of species complexes of Leishmania. Acta Tropica 56, 289-298.
16. Mottram, J. C., Souza, A. E., Hutchison, J. E., Carter, R., Frame, M. J., and Coombs, G. H. 1996. Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proceedings of the National Academy of Sciences of the United States of America 93, 6008-6013.
17. Mukkada, A. J., Meade, J. C., Glaser, T. A., and Bonventre, P. F. 1985. Enhanced metabolism of Leishmania donovani amastigotes at acid pH: An adaptation for intracellular growth. Science 229, 1099-1101.
18. Pan, A. A., and Pan, S. C. 1986. Leishmania mexicana: Comparative fine structure of amastigotes and promastigotes in vitro and in vivo. Experimental Parasitology 62, 254-265.
19. Pupkis, M. F., Tetley, L., and Coombs, G. H. 1986. Leishmania mexicana: Amastigote hydrolases in unusual lysosomes. Experimental Parasitology 62, 29-39.
20. Rivero-Lezcano, O. M., Chicharro, C., and Rivas, L. 1997. Acidic pH stress induces protein tyrosine phosphorylation in Leishmania pifanoi. Molecular & Biochemical Parasitology 84, 123-129.
21. Robertson, C. D., and Coombs, G. H. 1990. Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana. Molecular & Biochemical Parasitology 42, 269-276.
22. Robertson, C. D., and Coombs, G. H. 1994. Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array. Microbiology 140, 417-424.
23. Schneider, P., Rosat, J. P., Bouvier, J., Louis, J., and Bordier, C. 1992. Leishmania major: Differential regulation of the surface metalloprotease in amastigote and promastigote stages. Experimental Parasitology 75, 196-206.
24. Shapira, M., McEwen, J. G., and Jaffe, C. L. 1988. Temperature effects on molecular processes which lead to stage differentiation in Leishmania. EMBO Journal 7, 2895-2901.
25. Souza, A. E., Waugh, S., Coombs, G. H., and Mottram, J. C. 1992. Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana. FEBS Letters 311, 124-127.
26. Sturgill-Koszycki, S., Schlesinger, P. H., Chakraborty, P., Haddix, P. L., Collins, H. L., Fok, A. K., Allen, R. D., Gluck, S. L., Heuser, J., and Russell, D. G. 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase [see comments] [published erratum appears in Science 1994 Mar 11, 263(5152), 1359]. Science 263, 678-681.
27. Tchoupe, J. R., Moreau, T., Gauthier, F., and Bieth, J. G. 1991. Photometric or flourometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group. Biochimica et Biophysica Acta 1076, 149-151.
28. Veras, P. S., de Chastellier, C., and Rabinovitch, M. 1992. Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis. Journal of Experimental Medicine 176, 639-646.
29. Zilberstein, D., Blumenfeld, N., Liveanu, V., Gepstein, A., and Jaffe, C. L. 1991. Growth at acidic pH induces an amastigote stage-specific protein in Leishmania promastigotes. Molecular & Biochemical Parasitology 45, 175-178.
30. Zilberstein, D., and Gepstein, A. 1993. Regulation of L-proline transport in Leishmania donovani by extracellular pH. Molecular & Biochemical Parasitology 61, 197-205.
31. Zilberstein, D., and Shapira, M. 1994. The role of pH and temperature in the development of Leishmania parasites. [Review]. Annual Review of Microbiology 48, 449-470.