A practical synthesis of N-(4-isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro- 2H-benzo[1,4]oxazine-6-carbonyl)guanidine methanesulfonate (KB-R9032) utilizing potassium fluoride-alumina catalyzed N-alkylation

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 8, 1998, Pages 1317-1320

  Yamamoto, Takeshi ^a   Hori, Manabu ^a   Watanabe, Ikuo ^a   Tsutsui, Hisayoshi ^a   Ikeda, Shoji ^a   Ohtaka, Hiroshi ^a  

^a KANEBO LTD   (Japan)

Author keywords

Methyl 2,2 dimethyl 3 oxo 3,4 dihydro 2H benzo 1,4 oxazine 6 carboxylate; N O selectivity; N alkylation; Potassium fluoride alumina; Repeated alkylation

Indexed keywords

1 (3,4 DIHYDRO 4 ISOPROPYL 2,2 DIMETHYL 3 OXO 2H 1,4 BENZOXAZINE 6 CARBONYL)GUANIDINE; MESYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; COLUMN CHROMATOGRAPHY; DRUG SYNTHESIS; HYDROGEN BOND; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON SODIUM EXCHANGE; REPERFUSION INJURY;

EID: 0031751231     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.1317     Document Type: Article

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