Beneficial role of human endogenous retroviruses: Facts and hypotheses

Scandinavian Journal of Immunology

Volumn 48, Issue 4, 1998, Pages 329-338

  Larsson, E ^a,c   Andersson, G ^b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENVELOPE PROTEIN; MEMBRANE PROTEIN;

AUTOIMMUNITY; CANCER; CELL DIFFERENTIATION; CELL TYPE; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE THERAPY; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; REVIEW; TISSUE SPECIFICITY; VIRUS CELL INTERACTION; VIRUS ENVELOPE; XENOTRANSPLANTATION;

CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, VIRAL; HUMANS; RETROVIRIDAE; VIRUS REPLICATION;

EID: 0031751113     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00428.x     Document Type: Review

References (123)

1. Wilkinson DA, Mager DL, Leong JAC. Endogenous human retroviruses. In: Levy J, ed. The Retroviridae. New York: Plenum Press, 1994:465-535.
2. Löwer R, Löwer J, Kurth R. The viruses in all of us: characteristics and biological significance of human endogenous retroviruses. Proc Natl Acad Sci USA 1996;93:5177-84.
3. Coffin J. Endogenous viruses. In: Weiss R, Teich N, Varmus H, Coffin J, eds. RNA Tumor Viruses, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1984:1109-1203.
4. Levy JA. The multifaceted retrovirus. Cancer Res 1986;46:5457-68.
5. Luciw PA, Leung NJ. Mechanisms of retrovirus replication. In: Levy JA, ed. The Retroviridae, Vol. 1. New York, London: Plenum Press, 1992:159-298.
6. Weinberg RA. Origins and roles of endogenous retroviruses. Cell 1980;22:643-4.
7. Cohen M, Larsson E. Human endogenous retroviruses. Bioessays 1988;9:191-6.
8. Varmus H, Brown P. Retroviruses. In: Mobile DNA. Berg D, Howe M, eds. Washington DC: American Society for Microbiology, 1991:53-108.
9. Coffin J. Genetic diversity and evolution of retroviruses. Curr Topics Microbiol Immunol 1992;176:143-64.
10. Urnovitz H, Murphy WH. Human endogenous retroviruses: nature, occurrence and clinical implications in human disease. Clin Microbiol Rev 1996;9:72-99.
11. Krieg AM, Steinberg AD. Retroviruses and autoimmunity. J Autoimmun 1990;3:137-66.
12. Krieg AM, Gourley MF, Perl A. Endogenous retroviruses: potential etiologic agents in autoimmunity. FASEB J 1992;6:2537-44.
13. Abraham HN, Khan AS. Human endogenous retroviruses and immune disease. Clin Immunol Immunopathol 1990;56:1-8.
14. Löwer R, Boller K, Hasenmaier B et al. Identification of human endogenous retroviruses with complex mRNA expression and particle formation. Proc Natl Acad Sci USA 1993;90:4480-4.
15. Kato N, Pfeifer Ohlsson S, Kato M et al. Tissue-specific expression of human provirus ERV3 mRNA in human placenta: two of the three ERV3 mRNAs contain human cellular sequences. J Virol 1987;61:2182-91.
16. Kannan P, Buettner R, Pratt DR et al. Identification of a retinoic acid-inducible endogenous retroviral transcript in the human teratocarcinoma-derived cell line PA-1. J Virol 1991;65:6343-8.
17. La Mantia G, Maglione D, Pengue G et al. Identification and characterization of novel human endogenous retroviral sequences preferentially expressed in undifferentiated embryonal carcinoma cells. Nucl Acids Res 1991;19:1513-20.
18. Lerner R, Wilson CB, Del Villano BC et al. Endogenous oncorna virus expression in adult and fetal mice: quantitative histologic and physiologic studies of the major viral glycoprotein gp70. J Exp Med 1976;143:151-66.
19. Krieg AM, Gourley MF, Klinman DM et al. Heterogeneous expression and coordinate regulation of endogenous retroviral sequences in human peripheral blood mononuclear cells. Aids Res Hum Retroviruses 1991;8:1991-8.
20. Krieg AM, Gause WC, Gourley MF et al. A role for endogenous retroviral sequences in the regulation of lymphocyte activation. J Immunol 1989;143:2448-51.
21. Kato N, Larsson E, Cohen M. Absence of expression of a human retrovirus is correlated with choriocarcinoma. Int J Cancer 1988; 41:380-5.
22. Larsson E, Venables PJ, Andersson AC et al. Expression of an endogenous retrovirus ERV3 (HERV-R) during induced monocytic differentiation in the U937 cell line. Int J Cancer 1996;67:451-6.
23. Larsson E, Andersson AC, Nilsson BO. Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues-evidence for a function for envelope gene products. Uppsala J Med Sci 1994;99:113-20.
24. Lindeskog M, Medstrand P, Blomberg J. Sequence variation of human endogenous ERV9-related elements in an env region corresponding to an immunosuppressive peptide: transcription in normal and neoplastic cells. J Virol 1993;67:1122-6.
25. Medstrand P, Lindeskog M, Blomberg J. Characterization of novel human endogenous retroviral sequences similar to MMTV, IAP:s and HERV-K. Differential transcription of reverse transcriptase coding sequences in normal human tissues. J Virol 1993;67:6778-87.
26. Temin HM. Origin and general nature of retroviruses. In: Levy JA, ed. The Retroviridae, Vol. 1. New York: Plenum Press, 1992:1-18.
27. Doolittle WF, Sapienza C. Selfish genes, the phenotype paradigm and genome evolution. Nature 1980;284:601-3.
28. Orge L, Crick FHC. Selfish DNA. the ultimate parasite. Nature 1980;284:604-7.
29. Doolittle RF, Feng DF, Johnson MS. Origins and evolutionary relationships of retroviruses. Quant Rev Biol 1989;64:1-30.
30. Doolittle RF, Feng DF, McClure MA et al. Retrovirus phytogeny and evolution. Curr Topics Microbiol Immunol 1990;157:1-18.
31. Bucheton A. The relationship between the flamenco gene and gypsy in Drosophila: how 10 tame a retrovirus. Trends Genet 1995;11:349-53.
32. Coffin JM. Reverse transcriptase and evolution. In: Skalka AM, Goff SP, eds. Reverse Transcriptase. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1993:445-79.
33. Finnegan DJ. Retroviruses and transposable elements - which came first. Nature 1983;302:105-6.
34. Baltimore D. Retroviruses and retrotransposons: the role of reverse transcription in shaping the eukaryotic genome. Cell 1985;40:481-2
35. Zeyl C, Bell G. Symbiotic DNA in eukaryotic genomes. Trends Ecol Evol 1996;11:10-5.
36. Deinhardt F. Biology of primate retroviruses. In: Klein G, ed. Viral Oncology. New York: Raven Press, 1980:357-98.
37. Allen JS. Xenotransplantation at a crossroad: prevention versus progress. Nature Med 1996;2:18-21.
38. Stoye JP, Coffin JM. The dangers of xenotransplantation. Nature Med 1995;1:1100.
39. Temin HM. The protovirus hypothesis: speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis. J Natl Cancer Inst 1971;46:3-7.
40. Temin HM. Reverse transcriptases. Retrons in bacteria. Nature 1989;339:254-5.
41. Martin MA, Bryan T, Rasheed S et al. Identification and cloning of endogenous retroviral sequences in human DNA. Proc Natl Acad Sci USA 1981;78:4892-6.
42. Bonner T, O'Connell C, Cohen M. Cloned endogenous retroviral sequences from human DNA. Proc Natl Acad Sci USA 1982;79: 4709-13.
43. Callahan R, Drohan W, Tronick S et al. Detection and cloning of human DNA sequences related to the mouse mammary tumor virus genome. Proc Natl Acad Sci USA 1982;79:5503-7.
44. Benveniste RE, Heinemann R, Wilson GL et al. Detection of Baboon type-C viral sequences in various primate tissues by molecular hybridization. J Virol 1974;14:56-7.
45. Zucchi I, Schlessinger D. Distribution of moderately repetitive sequences pTR5 and LF1 in Xq24-q28 human DNA and their use in assembling YAC contigs. Genomics 1992;12:264-75.
46. Leib-Mösch MC, Brack WR, Werner T et al. Endogenous retroviral elements in human DNA. Cancer Res (Suppl 1) 1990;50:5636-42.
47. Leib-Mösch MC, Haltmeier M, Werner T et al. Genomic distribution and transcription of solitary HERV-K LTRs. Genomics 1993; 18:261-9.
48. Wallace RM, Anderson LB, Saulino AM et al. A de novo Alu insertion results in neurofibromatosis type I. Nature 1991;353:864-6.
49. Miki Y, Nishisho I, Horii A et al. Disruption of the APC gene by a retrotransposal insertion of Ll sequence in a colon cancer. Cancer Res 1992;52:643-5.
50. Kazazian HJ, Wong C, Youssoufian H et al. Haemophilia A resulting from de novo insertion of Ll sequences represents a novel mechanism for mutation in man. Nature 1988;332:164-6.
51. Larhammar D, Servenius B, Rask L et al. Characterization of a HLA-DRβ pseudogene. Proc Natl Acad Sci USA 1985;82:1475-9.
52. Mayer WE, O'hUigin C, Klein J. Resolution of the HLA-DRB6 puzzle: a case of grafting a de novo-generated exon on an existing gene. Proc Natl Acad Sci USA 1993;90:10720-4.
53. Maestre J, Tchénio T, Dhellin O, Heidmann T. mRNA retroposition in human cells: processed pseudogene formation. EMBO J 1995; 14:6333-8.
54. Ting CN, Rosenberg MP, Snow CM et al. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Genes Dev 1992;6:1457-65.
55. Di Cristofano A, Strazullo M, Longo L, La Mantia G. Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family. Nucl Acids Res 1995;23:2823-30.
56. Suzuki H, Hosokawa Y, Toda H et al. Common protein-binding sites in the 5′-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein. J Biol Chem 1990;265:8159-63.
57. Kato N, Shimotohno K, VanLeeuwen D, Cohen M. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. Mol Cell Biol 1990;10:4401-5.
58. Feuchter-Murthy AE, Freeman JD, Mage DL. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene. Nucl Acids Res 1993;21:135-43.
59. Goodchild NL, Wilkinson DA, Mager DL. A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta. Gene 1992;121: 287-94.
60. Mager DL, Goodchild NL. Homologous recombination between the LTRs of a human retrovirus-like element causes a 5-kb deletion in two siblings. Am J Hum Genet 1989;45:848-54.
61. Wu J, Zhou T, He J, Mountz JD. Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene. J Exp Med 1993;178:461-8.
62. Villareal LP. On viruses, sex and motherhood. J Virol 1997;71: 859-64.
63. Lyden TW, Johnson PM, Mwenda JM, Rote NS. Ultrastructural characterization of endogenous retroviral particles isolated from normal human placentas. Biol Reprod 1994;51:152-7.
64. Vernon ML, McMahon JM, Hackett JJ. Additional evidence of type-C particles in human placentas. J Natl Cancer Inst 1974;52: 987-9.
65. Bax CM, Ryder TA, Mobberley MA et al. Ultrastructural changes and immunocytochemical analysis of human placental trophoblast during short-term culture. Placenta 1989;10:179-94.
66. Leong JC, Wood SO, Lyford AO, Levy JA. Purification of a specific inhibitor of reverse transcriptase from human placenta. Int J Cancer 1984;33:435-9.
67. Yotsuyanagi Y, Szöllosi D. Virus-like particles and related expressions in mammalian oocytes and preimplantation stage embryos. In: van Blerkom J, Motta PM, eds. Ultrastructure of Reproduction. The Hague: Martinus Nijhoff, 1984:218-34.
68. Daniel JC, Chilton BS. Virus-like particles in embryos and female reproductive tract. In: Johnson MH, ed. Development Mammals 3. Amsterdam: North Holland, Oxford: Elsevier, 1978:131-87.
69. Larsson E, Nilsson BO, Sundström P, Widehn S. Morphological and microbiological signs of endogenous C-virus in human oocytes. Int J Cancer 1981;28:551-7.
70. Nilsson BO, Larsson E, Sundström P. Virus p30-related protein in follicular fluids and C virus-like particles on the cell membrane of the human oocyte. J In Vitro Fert Embryo Transfer 1986;3:296-303.
71. Nilsson BO, Kättström PO, Sundström P, Jaquemin P, Larsson E. Human oocytes express murine retroviral equivalents. Virus Genes 1992;6:221-7.
72. Kättström PO, Bjerneroth G, Nilsson BO, Holmdahl R, Larsson E. A retroviral gp70 related protein is expressed at specific stages during mouse oocyte maturation and in preimplantation embryos. Cell Diff Dev 1989;28:47-54.
73. Boyd MT, Bax CM, Bax BE, Bloxam DL, Weiss RA. The human endogenous retrovirus ERV-3 is upregulated in differentiating placental trophoblast cells. Virology 1993;196:905-9.
74. Larsson E, Andersson AC, Holmberg L et al. Expression of an endogenous retrovirus HERV R in human tissues. J Cancer Res Clin Oncol 1993;119 (Suppl. 1):6.
75. Venables PJW, Brookes SM, Griffiths D et al. Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. Virology 1995;211:589-92.
76. Harris JR. The evolution of placental mammals. FEBS Lett 1991; 295:3-4.
77. De Parseval N, Heidmann T. Physiological knockout of the envelope gene of the single copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population. J Virol 1998; 72:3442-5.
78. Kjellman C, Sjögren HO, Widegren B. The Y chromosome: a graveyard for endogenous retroviruses. Gene 1995;161:163-70.
79. Silver J, Rabson A, Bryan T et al. Human retroviral sequences on the Y chromosome. Mol Cell Biol 1987;7:1559-62.
80. Sinclair AH, Berta P, Palmer MS et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 1990;346:240-4.
81. Yamamoto KR. Steroid receptor regulated transcription of specific-genes and gene networks. Annu Rev Genet 1985;19:209-52.
82. Buetti E, Kuhnel B, Diggelmann H. Dual function of a nuclear factor I binding site in MMTV transcription regulation. Nucl Acids Res 1989;17:3065-78.
83. Gowland PL, Buetti E. Mutations in the hormone regulatory element of mouse mammary tumor virus differentially affect the response to progestins, androgens, and glucocorticoids. Mol Cell Biol 1989;9:3999-4008.
84. Cato ACB, Miksicek R, Schutz G et al. The hormone regulatory element of mouse mammary tumor virus mediates progesterone induction. EMBO J 1986;5:2237-40.
85. O'Connell C, O'Brien S, Nash WG, Cohen M. ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships. Virology 1984;138:225-35.
86. O'Connell CD, Cohen M. The long terminal repeat sequences of a novel human endogenous retrovirus. Science 1984;226:1204-6.
87. Andersson AC, Merza M, Venables PJ et al. Elevated levels of the endogenous retrovirus ERV-3 in human sebaceous glands. J Invest Dermatol 1996;106:125-8.
88. Ono M, Kawakami M, Ushikubo H. Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D. J Virol 1987;61:2059-62.
89. Welsh RMJ, Cooper NR, Jensen FC, Oldstone MBA. Human serum lysis RNA tumour viruses. Nature 1975;257:612-4.
90. Tralka TS, Yee CL, Rabson AB et al. Murine type C retroviruses and intracisternal A-particles in human tumors serially passaged in nude mice. J Natl Cancer Inst 1983;71:591-9.
91. Sarma PS, Cheong MP, Hartley JW, Huebner RJ. A viral interference test for mouse leukemia viruses. Virology 1967;33:180-4.
92. Nihrane A, Fujita K, Willey R, Lyu MS, Silver J. Murine leukemia virus envelope protein in transgenic-mouse serum blocks infection in vitro. J Virol 1996;70:1882-9.
93. Katz RA, Skalka AM. Generation of diversity in retroviruses. Annu Rev Genet 1990;24:409-45.
94. Sandmeyer SB, Hansen L, Chalker DL. Integration specificity of retrotransposons and retroviruses. Annu Rev Genet 1990;24:491-518.
95. Goff S. Genetics of retroviral integration. Annu Rev Genet 1992; 26:527-44.
96. Skalka AM, Leis J. Retroviral DNA integration. Bioessays 1979; 1:206-11.
97. Skalka AM. Retroviral DNA integration: lessons for transposon shuffling. Gene 1993;135:175-82.
98. Müller HP, Varmus HE. DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes. EMBO J 1994;13:4704-14.
99. Taruscio D, Manuelidis L. Integration site preferences of endogenous retroviruses. Chromosoma 1991;10:141-56.
100. Purcell DFJ, Broscius CM, Vanin EF et al. Array of murine leukemia virus-related elements is transmitted and expressed in a primate recipient of retroviral gene transfer. J Virol 1996;70:887-97.
101. Harris DT, Cianciolo GJ, Snyderman R et al. Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. J Immunol 1987;138:889-94.
102. Cianciolo GJ, Copeland TD, Oroszlan S, Snyderman R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 1985;230:453-5.
103. Benomar A, Wang JM, Taraboletti G et al. Chemotactic factor and p15E-related chemotaxis inhibitior in human melanoma cell lines with different macrophage content and tumourigenicity in nude mice. J Immunol 1987;138:2372-9.
104. Cianciolo GJ, Philips D, Snyderman R. Human malignant and mitogen-transformed cells contain retroviral p15E-related antigen. J Exp Med 1984;159:964-9.
105. Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends Genet 1993;9:138-41.
106. Jenkins NA, Copeland NG. Retroviral DNA content of the mouse genome. Birth Defects 1987;23:109-22.
107. Acha-Orbea H, MacDonald HR. Superantigens of mouse mammary tumor virus. Annu Rev Immunol 1995;13:459-86.
108. Conrad B, Weissmahr RN, Boni J et al. A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. Cell 1997;90:303-13.
109. Perron H, Garson JA, Bedin F et al. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. Proc Natl Acad Sci USA 1997;94:7583-8.
110. Nelson PN. Retroviruses in rheumatic diseases. Ann Rheum Dis 1995;54:441-2.
111. Hara I, Izui S, Dixon FJ. Murine serum glycoprotein gp70 behaves as an acute phase reactant. J Exp Med 1982;155:345-57.
112. Blomberg J, Nived O, Pipkorn R et al. Antibodies reactive with evolutionarily conserved retroviral gag peptide sequences in patients suffering from systemic lupus erythematosus (SLE). Arthritis Rheumatism 1993;37:57-66.
113. Brookes SM, Pandolfino YA, Mitchell TJ et al. The immune response to and expression of cross-reactive retroviral gag sequences in autoimmune disease. Br J Rheumatol 1992;31:735-42.
114. Pipkorn R, Toth L, Blomberg J. Synthetic peptides derived from human endogenous retroviruses: Ab reactivity in human sera. In: Schneider CH, ed. Peptides in Immunology. London: John Wiley, 1996:273-77.
115. Takeuchi K, Katsumata K, Ikeda H et al. Expression of endogenous retroviruses, ERV3 and lambda 4-1, in synovial tissues from patients with rheumatoid arthritis. Clin Exp Immunol 1995;99: 338-44.
116. Larsson E, Kato N, Cohen M. Human endogenous proviruses. Curr Topics Microbiol Immunol 1989;148:115-32.
117. Kambhu S, Falldorf P, Lee JS. Endogenous retroviral long terminal repeats within the HLA-DQ locus. Proc Natl Acad Sci USA 1990; 87:4927-31.
118. Badenhoop K, Tönjes RR, Rau H et al. Endogenous retroviral long terminal repeats of the HLA-DQ region are associated with susceptibility to insulin-dependent diabetes mellitus. Hum Immunol 1996;50:103-10.
119. Hayward WS. Multiple stages in avian leukosis virus-induced B cell lymphoma. In: Hanafusa H, Pinter A, Pullman ME, eds. Retroviruses and Disease. San Diego: Academic Press, 1989:57-65.
120. Bratthauer GL, Cardiff RD, Fanning GT. Expression of LINE-1 retrotransposons in human breast cancer. Cancer 1994;73:2333-6.
121. Lang MS, Oostendorp RA, Simons PJ et al. New monoclonal antibodies against the putative immunosuppressive site of retroviral p15E. Cancer Res 1994;54:1831-6.
122. Foulds S, Wakefield CH, Giles M et al. Expression of a suppressive p15E-related epitope in colorectal and gastric cancer. Br J Cancer 1993;68:610-6.
123. Teich N, Wyke J, Mak T, Bernstein A, Hard W. Pathogenesis of retrovirus-induced disease. In: Weiss R, Teich N, Varmus H, Coffin J, eds. RNA Tumor Viruses, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Press, 1984:785-998.