Nuclear factor-1 motif and redundant regulatory elements comprise phenobarbital-responsive enhancer in CYP2B1/2

DNA and Cell Biology

Volumn 17, Issue 5, 1998, Pages 461-470

  Liu, Siqing ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR I; PHENOBARBITAL;

ARTICLE; DNA FLANKING REGION; DNA PROTEIN COMPLEX; DRUG METABOLISM; ENHANCER REGION; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION REGULATION; GENE MAPPING; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0031750029     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.1998.17.461     Document Type: Article

References (5)

1. ADAMS, A.D., CHOATE, D.M., and THOMPSON, M.A. (1995). NF-1 is the DNA-binding component of the protein complex at the peripherin negative regulatory element. J. Biol. Chem. 270, 6976-6983.
2. ADESNIK, M., BAR-NUN, S., MASCHIO, P.M., ZUNICH, M., LIPPMAN, A., and BARD, E. (1981). Mechanism of induction of cytochrome P-450 by phenobarbital. J. Biol. Chem. 256, 10340-10345.
3. CHEN, D., LEPAR, G., and KEMPER, B. (1994). A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J. Biol. Chem. 269, 5420-5427.
4. DENISON, M.S., and WHITLOCK, J.P. (1995). Xenobiotic-inducible transcription of cytochrome P450 genes. J. Biol. Chem. 270, 18175-18179.
5. FRUEH, F.W., ZANGER, U.M., and MEYER, U.A. (1997). Extent and character of phenobarbital-mediated changes in gene expression in the liver. Mol. Pharmacol. 51, 363-369.