Overview of strategies for complex genetic diseases

Kidney International

Volumn 53, Issue 6, 1998, Pages 1441-1445

  Clerget Darpoux, Françoise ^a  

^a INSERM   (France)

Author keywords

Alleles; Genetic risk factors; Genome linkage test; Locus; Polymorphisms

Indexed keywords

ALLELE; GENETIC DISORDER; GENETIC LINKAGE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC RISK; KIDNEY DISEASE; PRENATAL SCREENING; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 0031749819     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00937.x     Document Type: Article

References (47)

1. MORTON NE: Sequential tests for the detection of linkage. Am J Hum Genet 7:277-318, 1955
2. CLERGET-DARPOUX F, BONAÏTI-PELLIÉ C, HOCHEZ J: Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393-399, 1986
3. TIWARI JL, HODGE SE, TERASAKI PI, SPENCE MA: HLA and the Inheritance of multiple sclerosis: Linkage of 72 pedigrees. Am J Hum Genet 31:103-111, 1980
4. CLERGET-DARPOUX F, GOVAERTS A, FEINGOLD N: HLA and susceptibility to multiple sclerosis. Tissue Antigens 24:160-169, 1984
5. CLERGET-DARPOUX F, BONAÏTI-PELLIÉ: C: An exclusion map covering the whole genome: A new challenge for genetic epidemiologists? Am J Hum Genet 52:442-443, 1993
6. DAY NE, SIMONS MJ: Disease susceptibility genes-their identification by multiple case family studies. Tissue Antigens 8:109-119, 1976
7. THOMSON G, BODMER W: The genetics of HLA and disease associations, in HLA and Disease, edited by DAUSSET J, SVEJGAARD A, Copenhagen, Munksgaard, 1977, pp 84-93
8. SUAREZ BK: The affected sib pair IBD distribution for HLA-linked disease susceptibility genes. Tissue Antigens 12:87-93, 1978
9. GREEN JR, WOODROW JC: Sibling method for detecting HLA-linked genes in disease. Tissue Antigens 9:31-35, 1977
10. WEEKS DE, LANGE K: The Affected Pedigree member method of linkage analysis. Am J Hum Genet 42:315-326, 1988
11. BISHOP DT, WILLIAMSON JA: The power of identity-by-state methods for linkage analysis. Am J Hum Genet 46:254-265, 1990
12. HASEMAN JK, ELSTON RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19, 1972
13. COMMENGES D: Robust genetic linkage analysis based on a score test of homogeneity: The weighted pairwise correlation statistic. Genet Epidemiol 11:189-200, 1994
14. RISCH N: Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 46:229-241, 1990
15. RISCH N: Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet 46:242-253, 1990
16. HOLMANS P: Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet 52:362-374, 1993
17. KRUGLYAK L, LANDER ES: Complete multipoint sib pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454, 1995
18. KRUGLYAK L, LANDER ES: High resolution genetic mapping of complex traits. Am J Hum Genet 56:1212-1223, 1995
19. EICHENBAUM-VOLINE S, GÉNIN E, BABRON MC, MARGARITTE-JEANNIN P, PRUM B, CLERGET-DARPOUX F: Caution in the interpretation of MLS. Genet Epidemiol (in press)
20. BABRON MC, MARTINEZ M, BONAÏTI-PELLIÉ C, CLERGET-DARPOUX F: Linkage detection by the affected-pedigree-member: What is really tested? Genet Epidemiol 10:389-394, 1993
21. OTT J: Strategies for characterizing highly polymorphic markers in human gene mapping. Am J Hum Genet 51:283-290, 1992
22. FREIMER NB, SANDKUIJL LA, BLOWER SM: Incorrect specification of marker allele frequencies: Effect on linkage analysis. Am J Hum Genet 56:1102-1110, 1993
23. HAUSER ER, BOEHNKE M, GUO SW, RISCH N: Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations. Genet Epidemiol 13:117-137, 1996
24. CLERGET-DARPOUX F, BONAÏTI-PELLIÉ C, FEINGOLD J: Marqueurs génétiques et maladies multifactorielles. Quelle stratégie adopter? Méd Sciences 8:1065-1071, 1992
25. SPIELMAN RS, MCGINNINS RE, EWENS WJ: Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516, 1993
26. SHAM PC, CURTIS D: An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 59:323-336, 1995
27. BICKEBÖLLER H, CLERGET-DARPOUX F: Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers. Genet Epidemiol 12:865-870, 1995
28. FALK CT, RUBINSTEIN P: Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233, 1987
29. TERWILLIGER J, OTT J: A haplotype-based "haplotype relative risk" approach to detecting allelic association. Hum Heredity 42:337-346, 1992
30. KNAPP M, SEUCHTER SA, BAUR MP: The haplotype-relalive risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet 52:1085-1093, 1993
31. SCHAID DJ: General score tests for associations of genetic markers with disease using cases and their parents. Genet Epidemiol 12:117-137, 1996
32. CLERGET-DARPOUX F, BABRON MC, BICKEBÖLLER H: Comparing the power of linkage detection by the transmission disequilibrium test and the identity by deseent test. Genet Epidemiol 12:583-588, 1995
33. YAOUANQ J, SEMANA G, EICHENBAUM S, QUELVENNEC E, ROTH MP, CLANET M, EDAN G, CLERGET-DARPOUX F: Evidence for linkage disequilibriium between HLA-DRB1 gene and multiple sclerosis. Science 276:664-665, 1997
34. THOMSON G: Investigation of the mode inheritance of the HLA associated disease by the method of antigen genotype frequencies among diseased individuals. Tissue Antigens 21:81-104, 1983
35. RISCH N: A general model for disease-marker association. Ann Hum Genet 47:245-252, 1983
36. CLERGET-DARPOUX F, BABRON MC, PRUM B, LATHROP GM, DESCHAMPS I, HORS J: A new method to test genetic models in HLA associated diseases: The MASC method. Ann Hum Genet 52:247-258, 1988
37. DIZIER M-H, BABRON M-C, CLERGET-DARPOUX F: Interactive effect of two candidate genes in a disease: Extension of the MASC method. Am J Hum Genet 55:1042-1049, 1994
38. PRUM B, GUILLOUD-BATAILLE M, CLERGET-DARPOUX F: On the use of chi-square tests for nested categorized data. Ann Hum Genet 54:315-320, 1990
39. CLERGET-DARPOUX F, BABRON MC, DESCHAMPS I, HORS J: Complementation and maternal effect in insulin dependent diabetes. Am J Hum Genet 49:42-49, 1991
40. CLERGET-DARPOUX F, BABRON MC: HLA - Sclérose en plaque. Inférences génétiques, in Jumeaux et Sclérose en Plaques, edited by Álpérovitch A, Hors J, Lyon-Caen O, Paris, John Libbey Eurotext, 1993, pp 5-10
41. CLERGET-DARPOUX F, BOUGUERRA F, KASTALLY R, SEMANA G, BABRON M-C, DEBBABI A, BENNACEUR B, ELIAOU J-F: High risk genotypes for celiac disease. CRAS 317:931-936, 1994
42. KHALIL I, D'AURIOL L, GOBET M, MORIN L, LEPAGE V, DESCHAMPS I, SIK PARK M, DEGOS L, GALIBERT F, HORS J: A combination of HLA-DQ beta Asp57-negative and HLA-DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus. J Clin Invest 85:1315-1319, 1990
43. BELL GI, HORITA S, KARAM JH: A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33:176-183, 1984
44. FIELD LL: Genes predisposing to insulin-dependent diabetes in multiplex families. Genet Epidemiol 6:101-106, 1989
45. THOMSON G, ROBINSON WP, KUHNER ML, JOE S, KLITZ W: HLA and insulin gene associations with IDDM. Genet Epidemiol 6:155-160, 1989
46. BENNET ST, LUCASSEN AM, GOUGH SCL, POWELL EE, UNDLIEN DE, PRITCHARD LE, MERRIMAN ME, KAWAGUCHI Y, DRONSFIELD MJ, POCIOT F, NERUP J, BOUZEKRI N, CAMBON-THOMSEN A, RONNINGEN KS, BARNETT AH, BAIN SC, TODD JA: Susceptibility to human type 1diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genet 9:284-292, 1995
47. TODD J: Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci USA 92:8560-8565, 1995