Prostaglandin E2 alterations during sepsis are partially mediated by endotoxin-lnduced inhibition of prostaglandin 15-hydroxydehydrogenase

Journal of Trauma - Injury, Infection and Critical Care

Volumn 44, Issue 5, 1998, Pages 777-782

  Hahn, Elisabeth L ^a   Clancy, K D ^b   Tai, H H ^b   Ricken, J D ^b   He, L K ^b   Gamelli, R L ^b  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; ENDOTOXIN; MESSENGER RNA; PROSTAGLANDIN E2; 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE; LIPOPOLYSACCHARIDE;

ANIMAL MODEL; ARTICLE; BURN; CONTROLLED STUDY; ENZYME INHIBITION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA ANALYSIS; SEPSIS; STATISTICAL ANALYSIS; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; ESCHERICHIA COLI; GENETICS; LUNG; METABOLISM;

ANIMALS; BURNS; DINOPROSTONE; ESCHERICHIA COLI; HYDROXYPROSTAGLANDIN DEHYDROGENASES; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; RNA, MESSENGER; SEPSIS;

EID: 0031749385     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005373-199805000-00006     Document Type: Article

References (28)

1. Curreri WP, Luterman A, Braun DW: Burn injury analysis of survival and hospitalization time for 937 patients. Ann Surg. 1980;192:472.
2. 2)-dependent suppression of interleukin-2 production in patients with major trauma. J Trauma. 1987;27:837.
3. 2 level by antiserum against core lipopolysaccharide in a rabbit model of multiple organ failure. J Trauma. 1996;40:270.
4. 2 production in severely injured patients. Arch Surg. 1988;123:293.
5. Gamelli RL, He L, Liu H: Marrow granulocyte-macrophage progenitor cell response to burn injury as modified by endotoxin and indomethacin. J Trauma. 1994;37:339.
6. Gamelli RL, Herbert JC, Foster RS: Effect of burn injury on granulocyte and macrophage production. J Trauma. 1985; 25:615.
7. Gamelli RL, He L, Liu H: Macrophage suppression of granulocyte and macrophage growth following burn wound infection. J Trauma. 1994;37:339.
8. 2 by macrophages isolated after thermal injury and bacterial translocation. Circ Shock. 1994;42:154
9. Gerritsen ME: Physiological and pathophysiological roles of eicosanoids in the microcirculation. Cardiovasc Res. 1996; 32:720.
10. Chan CC, Boyce S, Brideau C, et al.: Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745, 337: a novel nonsteriodal anti-inflammatory agent with ulcerogenic sparing effect in rat and nonhuman promate stomach. J Pharm Exp Ther. 1995;274:1531.
11. Wyllie JH, Piper PJ, Vane JR: Fate of prostaglandins in the lungs. Br J Surg. 1969;56:623.
12. Piper PJ: Release and metabolism of prostaglandins in lung tissue. J Pharm Pharmacol. 1976;26:61.
13. Piper PJ, Vane JR, Wyllie JH: Inactivation of prostaglandins by the lungs. Nature. 1970;225:600.
14. +-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase. Crit Rev Biochem Mol Biol. 1996;31:101.
15. 2. J Surg Res. 1990;48:523.
16. 2 blocks inflammation, hyperalgesia and interleukin 6 production in vivo. J Exp Med. 1996;184:883.
17. Arias-Negrete S, Keller K, Chadee K: Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem Biophys Res Commun. 1995; 208:582.
18. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156.
19. Clancy KD, Lorenz K, Hahn E, et al.: Down-regulation of tissue specific tumor necrosis factor-α in the liver and lung after burn injury and endotoxemia. J Trauma. 1997;42:169.
20. Fourney RM, Miyashi J, Day RS: Northern blotting: efficient RNA staining and transfer. FOCUS. 1988;10:5.
21. +-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim Biophys Acta. 1996;1309:21.
22. Robertson RP: Molecular regulation of prostaglandin synthesis. Implications for endocrine systems. TEM. 1995; 6:293.
23. Feng L, Xia Y, Garcia GE: Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-α and lipopolysaccharide. J Clin Invest. 1995;95:1669.
24. Nakano J, Prancan AV: Metabolic degradation of prostaglandin E1 in the lung and kidney of rats in endotoxic shock. Proc Soc Exp Biol Med. 1973;144:506.
25. Vanmeir CA, Matthews SG, Keirse MJNC: 15-Hydroxyprostaglandin dehydrogenase-implications in preterm labor with and without ascending infection. J Clin Endocrin Metab. 1997;82:969.
26. Matsuo M, Ensor CM, Tsai HH: Characterization of the genomic structure and the promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene. Biochem Biophys Res Commun. 1997;235:582.
27. Tai HH, Hollander CS: Regulation of prostaglandin metabolism: activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imiprazine related drugs. Biochem Biophys Res Commun. 1976;68:814.
28. Tarazona R, Gonzalez-Garcia A, Zamzami N: Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. J Immunol. 1995;154:861.