Prediction of an antisense-effective target site on VEGFmRNA by using RNase H and a library of random oligonucleotides

Analytica Chimica Acta

Volumn 365, Issue 1-3, 1998, Pages 55-58

  Matsuda, Yoko ^a   Kamiya, Kinya ^a   Uchida, Kiyoshi ^a  

^a Base Technology Center   (Japan)

Author keywords

Antisense oligonucleotide; mRN; Randomized sequences of oligonucleotide; RNase H; Targeting of antisense effective site; VEGF VPF

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; RIBONUCLEASE H; VASCULOTROPIN;

ARTICLE; AUTORADIOGRAPHY; GEL ELECTROPHORESIS; GENE EXPRESSION; GENE TARGETING; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; RNA CLEAVAGE; RNA TRANSCRIPTION; RNA TRANSLATION;

EID: 0031748488     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(97)00581-3     Document Type: Article

References (10)

1. Hélène C., Toulme J.-J. Biochim. Biophys. Acta. 1049:1990;99.
2. S.T. Crooke, Therapeutic Applications of Oligonucleotides. R.G. Landes Company, Austin, TX, 1995.
3. Shuttleworth J., Colman A. EMBO J. 7:1988;427.
4. Y Chiang M.-, Chan H., Zounes M.A., Freier S.M., Lima W.F., Bennett C.F. J. Biol. Chem. 266:1991;18162.
5. Giles R.V., Spiller D.G., Tidd D.M. Antisense Research and Development. 5:1995;23.
6. Condon T.P., Bennett C.F. J. Biol. Chem. 271:1996;30398.
7. Ho S.P., Britton D.H.O., Stone B.A., Behrens D.L., Leffet L.M., Hobbs F.W., Miller J.A., Trainor G.L. Nucleic Acids Res. 24:1996;1901.
8. Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J.C., Abraham J.A. J. Biol. Chem. 266:1991;11947.
9. Uchida K., Uchida T., Tanaka Y., Matsuda Y., Kondo S. Antisense Research and Development. 5:1995;87.
10. Lima W.F., Brown-Driver V., Fox M., Hanecak R., Bruice T.W. J. Biol. Chem. 272:1997;626.