Improved syntheses of the PET radioligands, [11C]FLB 457, [11C]MDL 100907 and [11C]β-CIT-FE, by the use of [11C]Methyl triflate

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 41, Issue 6, 1998, Pages 545-556

  Lundkvist, Camilla ^a   Sandell, Johan ^a   Någren, Kjell ^b   Pike, Victor W ^c   Halldin, Christer ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TURKU PET CENTRE   (Finland)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

FLB 457; MDL 100907; 11C Methyl triflate; CIT FE

Indexed keywords

ALKYLATION; AMINES; METHYLATION;

DOPAMINE TRANSPORTERS; FLB 457; LABELINGS; MDL 100907; METHYL TRIFLATES; PET RADIOLIGAND; RADIOLIGANDS; [11C]METHYL TRIFLATE; Β-CIT; Β-CIT-FE;

PHENOLS;

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ISOREMOXIPRIDE; RADIOLIGAND;

ARTICLE; DRUG SYNTHESIS; ISOTOPE LABELING; METHYLATION; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RADIOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 0031746923     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199806)41:6<545::AID-JLCR99>3.0.CO;2-7     Document Type: Article

References (22)

1. Långström B. and Lundqvist H. - Int. J. Appl. Radiat. Isot. 27, 357, (1976)
2. Marazano C., Maziere M., Berger G. and Comar D. - Int. J. Appl. Radiat. Isot. , 49, (1977)
3. Jewett D. M. - Appl. Radiat. Isot. 41, 1383, (1992)
4. Chakraborty P. K., Gildersleeve D. L., Jewett D. M, Toorongian S. A., Kilbourn M. R., Schweiger M. and Wieland D. M. - Nucl. Med. Biol. 20, 939, (1993)
5. Bender D., Holschbach M. and Stöcklin G. - Nucl. Med. Biol. 21, 921, (1994)
6. Någren K., Halldin C. and Lundkvist C. - J. Labelled Cmpd. Radiopharm 37, 103, (1995)
7. Någren K., Halldin C., Müller L., Swahn C.-G. and Lehikonen P. - Nucl. Med. Biol. 22, 965, (1995)
8. Någren K., Müller L., Halldin C., Swahn C.-G. and Lehikonen P. - Nucl. Med. Biol. 22, 235, (1995)
9. Rosario R. B. and Wieland D. M. - J. Labelled Cmpd. Radiopharm 36, 625, (1995)
10. Zheng Q.-H. and Mulholland G. K. - Nucl. Med. Biol. 23, 981, (1996)
11. Halldin C., Farde L., Högberg T., Mohell N., Hall H., Suhara T., Karlsson P., Nakashima Y. and Swahn C.-G. - J. Nucl. Med. 36, 1275, (1995)
12. Lundkvist C., Halldin C., Ginovart N., Nyberg S., Swahn C.-G., Carr A. A., Brunner F. and Farde L. - Life Science 58, PL 187, (1996)
13. Mathis C. A., Simpson N. R., Mahmood K., Kinahan P. E. and Mintun M. A. - Life Science 55, PL403, (1994)
14. Pike W. V., McCarron J. A., Hume S. P., Ashworth S., Opacka-Juffry J., Osman S., Lammertsma A. A., Poole K. G., Fletcher A., White A. C. and Cliffe I. A. - Med. Chem. Res. 5, 208, (1994)
15. Pike V. W., McCarron J., Lammertsma A. A., Hume S. P., Poole K., Grasby P. M., Malizia A., Cliffe I. A. and Fletcher A. - Eur. J. Pharmacol. 281, R1, (1995)
16. Pike V. W., McCarron J., Lammertsma A. A., Osman S., Bench C. J., Grasby P. M., Cliffe I. A. and Fletcher A. - Eur. J. Pharmacol. 301, R5, (1996)
17. Lundkvist C., Halldin C., Swahn C.-G., Müller L., Ginovart N., Nakashima Y., Karlsson P., Neumeyer J. L., Wang S., Milius R. A. and Farde L. - J. Labelled Cmpd. Radiopharm. 37, 52, (1995)
18. Halldin C., Farde L., Lundkvist C., Ginovart N., Nakashima Y., Karlsson P. and Swahn C. G. - Synapse 22, 386, (1996)
19. Günther I., Hall H., Halldin C., Swahn C.-G., Farde L. and Sedvall G. - Nucl. Med. Biol. 24, 629, (1997)
20. Swahn C.-G., Halldin C., Günther I., Patt J. and Ametamey S. - J. Labelled Cmpd. Radiopharm. 38, 675, (1996)
21. Halldin C., Farde L., Högberg T., Hall H. and Sedvall G. - Appl. Radiat. Isot. 41, 669, (1990)
22. Hall H., Lundkvist C., Halldin C., Farde L., Pike V. W., McCarron J. A., Fletcher A., Cliffe I. A., Barf T., Wikström H. and Sedvall G. - Brain Research 745, 96, (1997)