Effect of D-002 on the pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea-pig

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 5, 1998, Pages 549-553

  Noa, Miriam ^a   Mas, Rosa ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; CARRAGEENAN; D 002; POLYSORBATE 20; PROPOLIS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON MUCOSA; COLON ULCER; CONTROLLED STUDY; DRUG EFFECT; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MALE; NEUTROPHIL; NONHUMAN;

EID: 0031745156     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb06197.x     Document Type: Article

References (23)

1. Becken, W. L. (1988) Experimental inflammatory bowel disease. In: Kirsner, J. B., Shorter, R. G. (eds) Inflammatory Bowel Disease. Lea and Febiger, Philadelphia, pp 37-49
2. Benitz, K., Golberg, L., Coulston, F. (1973) Intestinal effects of carrageenans in the rhesus monkey (Macaca mulatta). Food Cosmet. Toxicol. 11: 565-575
3. Buell, M., Berin, C. (1994) Neutrophil-independence of the initiation of colonic injury. Comparison of results from three models of experimental colitis in the rat. Dig. Dis. Sci. 39: 2575-2588
4. Carbajal, D., Molina, V., Valdés, S., Arruzazabala, M. L., Más, R. (1995) Anti-ulcer activity of higher primary alcohols from beeswax. J. Pharm. Pharmacol. 47: 731-733
5. Carbajal, D., Molina, V., Valdés, S., Arruzazabala, M. L., Rodeiro, I., Más, R., Magraner, J. (1996) Possible cytoprotective mechanism in rats of D-002, an anti-ulcerogenic product isolated from beeswax. J. Pharm. Pharmacol. 48: 858-860
6. Engster, M., Abraham, R. (1976) Cecal response to different molecular weights and types of carrageenan in the guinea-pig. Toxicol. Appl. Pharmacol. 38: 265-282
7. Grasso, P., Sharrat, M., Carpanini, F., Gangolli, S. (1973) Studies on carrageenan and large bowel ulceration in mammals. Food Cosmet. Toxicol. 11: 555-564
8. Grisham, M., Benoit, J., Granger, D. (1990) Assessment of leucocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol. 186: 729-741
9. Kubes, P., Arfors, K., Granger, D. (1991) Platelet-activation factor-induced mucosal dysfunction: role of oxidants and granulocytes. Am. J. Physiol. 260: G965-G971
10. Kvietyz, P., Twohig, B., Danzell, J., Specian, R. (1990) Ethanol-induced injury to the rat gastric mucosa. Gastroenterology 98: 909-920
11. Ling, K., Bhalla, D., Hollander, D. (1988) Mechanisms of carrageenan injury of HEC18 small intestinal epithelial cell monolayers. Gastroenterology 95: 1487-1495
12. MacPherson, B., Pfeiffer, C. (1978) Experimental production of diffuse colitis in rats. Digestion 17: 135-150
13. Marcus, A., Marcus, S., Marcus, R., Watt, J. (1989) Rapid production of ulcerative disease of the colon in newly-weaned guinea-pigs by degraded carrageenan. J. Pharm. Pharmacol. 41: 423-426
14. Marcus, S., Marcus, A., Marcus, R., Ewen, S., Watt, J. (1992) The pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea-pig. Int. J. Exp. Path. 73: 515-526
15. McGill, H., McMahan, A., Wigodsky, H. (1977) Carrageenan in formula and infant baboon development. Gastroenterology 73: 512-517
16. Mascolo, N., Izzo, A., Autore, G., Maiello, F., Di Carlo, G., Capasso, F. (1995) Acetic acid-induced colitis in normal and essential fatty acid deficient rats. J. Pharmacol. Exp. Ther. 272: 469-475
17. Morris, G., Beck, P., Herridge, M., Depew, W., Szewczuk, M., Wallace, J. (1989) Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96: 795-803
18. Nygard, G., Anthony, A., Piasecki, C., Trevethick, M., Hudson, M., Dhillon, A., Pounder, R., Wakefield, A. (1994) Acute indomethacin-induced jejunal injury in the rat. Early morphological and biochemical changes. Gastroenterology 106: 567-575
19. Rachmilewitz, D., Simon, P., Schwartz, L., Don Griswold, E., Fondacaro, J., Wasserman, M. (1989) Inflammatory mediators of experimental colitis in rats. Gastroenterology 97: 326-337
20. Ukabam, S., Clamp, J., Cooper, B. (1983) Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon. Digestion 27: 70-74
21. Wallace, J., Keenan, C., Granger, D. (1990) Gastric ulceration induced by nonsteroidal anti-inflammatory drug is a neutrophil-dependent process. Am. J. Physiol. 259: G462-G467
22. Wallace, J., Keenan, C., Gale, D., Shoupe, T. S. (1992) Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis. Gastroenterology 102: 18-27
23. Watt, J., Marcus, R. (1971) Carrageenan-induced ulceration of the large intestine in the guinea-pig. Gut 12: 164-171